Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Nicola Porta"'
Autor:
Nicola Porta, Alexander Veljko Fejzagić, Kathryn Dumschott, Beatrix Paschold, Björn Usadel, Jörg Pietruszka, Thomas Classen, Holger Gohlke
Publikováno v:
Catalysts, Vol 12, Iss 10, p 1195 (2022)
Halogenating enzymes have evolved in considerable mechanistic diversity. The apparent need for secondary metabolism coincides with the current need to introduce halogens in synthetic products. The potential of halogenating enzymes and, especially, va
Externí odkaz:
https://doaj.org/article/547797ec1ab544acb4ce0f568f8d8446
Autor:
Daniel Mulnaes, Irina Apanasenko, Lothar Gremer, Jens Reiners, Nicola Porta, Sander H. J. Smits, Philipp Neudecker, Rebecca Clemens, Holger Gohlke
Publikováno v:
Journal of chemical theory and computation 16(3), 1953-1967 (2020). doi:10.1021/acs.jctc.9b00825
Knowledge of protein structures is essential to understand proteins' functions, evolution, dynamics, stabilities, and interactions and for data-driven protein- or drug design. Yet, experimental structure determination rates are far exceeded by that o
Autor:
Eleni Vrontaki, Nicola Porta, Guido Sello, Masamitsu Honma, Serena Manganelli, Domenico Gadaleta, Alberto Manganaro, Emilio Benfenati
Publikováno v:
Journal of Environmental Science and Health, Part C. 35:239-257
Azo dyes have several industrial uses. However, these azo dyes and their degradation products showed mutagenicity, inducing damage in environmental and human systems. Computational methods are proposed as cheap and rapid alternatives to predict the t
Autor:
Julia Zaschke-Kriesche, Benedikt Frieg, Sander H. J. Smits, Holger Stark, Mohanraj Gopalswamy, Manuel Etzkorn, Aleksandra Zivkovic, Nicola Porta, Holger Gohlke
Publikováno v:
Bioorganic & medicinal chemistry 27(20), 115079 (2019). doi:10.1016/j.bmc.2019.115079
Lantibiotics are antimicrobial peptides produced by Gram-positive bacteria and active in the nanomolar range. Nisin is the most intensely studied and used lantibiotic, with applications as food preservative and recognized potential for clinical usage
Autor:
Michele Mattiussi, Renzo Bagnati, Marco Marzo, Nicola Porta, Emilio Benfenati, Marco Lodi, Alice Passoni, Valentina Pieri, Fabrizio Natolino, Alberto Manganaro, Diego Baderna, Isabella Romeo, Eleonora Aneggi, Anna Lutman, Andrea Colombo, Daniele Goi, Giuseppa Raitano
Publikováno v:
Environment international. 119
Contaminants giving rise to emerging concern like pharmaceuticals, personal care products, pesticides and Endocrine Disrupting Chemicals (EDCs) have been detected in wastewaters, as reported in the literature, but little is known about their (eco)tox
Publikováno v:
Toxicology. 370
Cancer is one of the main causes of death in Western countries, and a major issue for human health. Prolonged exposure to a number of chemicals was observed to be one of the primary causes of cancer in occupationally exposed persons. Thus, the develo
Publikováno v:
Nuclear Receptor Research, Vol 3, Pp 1-13 (2016)
The identification of endocrine disrupting chemicals (EDCs) is one of the important goals of environmental chemical hazard screening. We report on in silico methods addressing toxicological studies about EDCs with a special focus on the application o
Autor:
Stefano Moro, Giampiero Spalluto, Stephanie Federico, Karl-Norbert Klotz, Antonella Ciancetta, Giorgia Pastorin, Nicola Porta, Barbara Cacciari, Sara Redenti
The structure–activity relationship of new 5,7-disubstituted-[1,2,4]triazolo[1,5-a][1,3,5]triazines as adenosine receptors (ARs) antagonists has been explored. The introduction of a benzylamino group at C5 with a free amino group at C7 increases th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd85f081a5763aa9b4285a955a01846b
http://hdl.handle.net/11577/3181863
http://hdl.handle.net/11577/3181863
Autor:
Stefano Moro, Giorgia Pastorin, Stephanie Federico, Sara Redenti, Antonella Ciancetta, Giampiero Spalluto, Karl-Norbert Klotz, Nicola Porta, Barbara Cacciari
Publikováno v:
Journal of medicinal chemistry. 57(14)
The structure–activity relationship (SAR) of new 5,8-disubstituted-1,2,4-triazolo[1,5-c]pyrimidines as adenosine receptors (ARs) antagonists has been explored. All the synthesized compounds show affinity for the hA2A and hA3 ARs depending on the su
Autor:
Fabrizio Vincenzi, Daniela Catarzi, Stefano Moro, Antonella Ciancetta, Lucia Squarcialupi, Flavia Varano, Pier Andrea Borea, Katia Varani, Nicola Porta, Marco Betti, Vittoria Colotta
In previous research, several 7-amino-2-arylpyrazolo[4,3-d]pyrimidine derivatives were identified as highly potent and selective antagonists at the human A3 adenosine receptor. Structure–activity relationship studies highlighted that affinity and s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3474f5bda13996ecf14c437d8b4f6db6
http://hdl.handle.net/11392/2278818
http://hdl.handle.net/11392/2278818