Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Nicola Pomella"'
Autor:
James Boot, Gabriel Rosser, Dailya Kancheva, Claire Vinel, Yau Mun Lim, Nicola Pomella, Xinyu Zhang, Loredana Guglielmi, Denise Sheer, Michael Barnes, Sebastian Brandner, Sven Nelander, Kiavash Movahedi, Silvia Marino
Publikováno v:
eLife, Vol 11 (2022)
We describe a subset of glioblastoma, the most prevalent malignant adult brain tumour, harbouring a bias towards hypomethylation at defined differentially methylated regions. This epigenetic signature correlates with an enrichment for an astrocytic g
Externí odkaz:
https://doaj.org/article/da3de84103274f4e822d1df1abc6378c
Autor:
Claire Vinel, Gabriel Rosser, Loredana Guglielmi, Myrianni Constantinou, Nicola Pomella, Xinyu Zhang, James R. Boot, Tania A. Jones, Thomas O. Millner, Anaelle A. Dumas, Vardhman Rakyan, Jeremy Rees, Jamie L. Thompson, Juho Vuononvirta, Suchita Nadkarni, Tedani El Assan, Natasha Aley, Yung-Yao Lin, Pentao Liu, Sven Nelander, Denise Sheer, Catherine L. R. Merry, Federica Marelli-Berg, Sebastian Brandner, Silvia Marino
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
The identification of patient-specific disease mechanisms and druggable targets is crucial for precision medicine in glioblastoma. Here, the authors show that comparing patients-matched glioma-initiating cells with neural stem cells enables the disco
Externí odkaz:
https://doaj.org/article/eef727b592d24a7697303fa96e18e608
Autor:
Sara Badodi, Nicola Pomella, Xinyu Zhang, Gabriel Rosser, John Whittingham, Maria Victoria Niklison-Chirou, Yau Mun Lim, Sebastian Brandner, Gillian Morrison, Steven M. Pollard, Christopher D. Bennett, Steven C. Clifford, Andrew Peet, M. Albert Basson, Silvia Marino
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
BMI1 and CHD7 are chromatin remodelling genes with a role in medulloblastoma pathogenesis. Here, the authors demonstrate that the BMI1High/CHD7Low signature mediates metabolic adaptation in G4 MB and predicts response to inositol treatment either alo
Externí odkaz:
https://doaj.org/article/e099abd2067e489ba7b766a7107a8238
Autor:
Alexander Neil Young, Emerald Perlas, Nerea Ruiz-Blanes, Andreas Hierholzer, Nicola Pomella, Belen Martin-Martin, Alessandra Liverziani, Joanna W. Jachowicz, Thomas Giannakouros, Andrea Cerase
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-8 (2021)
Young et al. report a new mouse model for Pelger-Huet anomaly, a genetic disorder caused by mutations in the Lamin B receptor gene (Lbr) that leads to abnormal neutrophil differentiation and skeletal defects. Using CRISPR/Cas-9 editing of Lbr, which
Externí odkaz:
https://doaj.org/article/a0388b7db1f045ad87ee722dcc675a86
Autor:
Ashirwad Merve, Xinyu Zhang, Nicola Pomella, Serena Acquati, Joerg D. Hoeck, Anaelle Dumas, Gabriel Rosser, Yichen Li, Jennie Jeyapalan, Silvia Vicenzi, Qianhai Fan, Zeng Jie Yang, Arianna Sabò, Denise Sheer, Axel Behrens, Silvia Marino
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-18 (2019)
Abstract Choroid plexus tumours (CPTs) account for 2–5% of brain tumours in children. They can spread along the neuraxis and can recur after treatment. Little is known about the molecular mechanisms underlying their formation and only few high fide
Externí odkaz:
https://doaj.org/article/124de95b234e4a8aad17a71b1c6fbb08
Autor:
Ashirwad Merve, Xinyu Zhang, Nicola Pomella, Serena Acquati, Joerg D. Hoeck, Anaelle Dumas, Gabriel Rosser, Yichen Li, Jennie Jeyapalan, Silvia Vicenzi, Qianhai Fan, Zeng Jie Yang, Arianna Sabò, Denise Sheer, Axel Behrens, Silvia Marino
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-1 (2019)
In the original version of this article [1], there was 1 error in the affiliation of the European Institute of Oncology (affiliation 3). In this correction article the updated affiliation is shown for clarification.
Externí odkaz:
https://doaj.org/article/2cc49146c06e48cda6fef5ed68f93a65
Autor:
Nicola Pomella, Christina Kolyva, Ernst Rietzschel, Patrick Segers, Ashraf W. Khir, Madalina Negoita
Publikováno v:
Artery Research, Vol 16 (2016)
Background: Reservoir-wave model assumes the measured pressure (Pm) consists of two additive components: reservoir (Pr) and excess pressure (Pex)1–2. Calculation of Pr requires fitting the diastolic decay of Pm for calculating parameters P∞ (asym
Externí odkaz:
https://doaj.org/article/a74a5321177b4f91b483dafd5f07be7a
Autor:
Nicola Pomella, Eurico Wilhelm Neto, Christina Kolyva, Mark Rakobowchuk, Jose Gonzalez-Alonso, Ashraf William Khir
Publikováno v:
Artery Research, Vol 12 (2015)
Background: The study of wave reflections in the carotid artery may reveal the vasoactive response of the cerebral circulation to exercise, which is not yet fully characterised. Therefore, we aim to examine the effect of exercise on wave intensity pa
Externí odkaz:
https://doaj.org/article/f3daf82287744574b23f61d7b2d13552
Autor:
James R. Boot, Denise Sheer, Vardhman K. Rakyan, Catherine L.R. Merry, Claire Vinel, Sebastian Brandner, Sven Nelander, Yung-Yao Lin, Suchita Nadkarni, Tedani El Assan, Juho Vuononvirta, Thomas O Millner, Federica M. Marelli-Berg, Myrianni Constantinou, Loredana Guglielmi, Jamie L. Thompson, Xinyu Zhang, Gabriel Rosser, Tania A. Jones, Pentao Liu, Nicola Pomella, Anaelle A. Dumas, Jeremy Rees, Natasha Aley, Silvia Marino
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Nature Communications
Nature Communications
Epigenetic mechanisms which play an essential role in normal developmental processes, such as self-renewal and fate specification of neural stem cells (NSC) are also responsible for some of the changes in the glioblastoma (GBM) genome. Here we develo
Autor:
James Boot, Gabriel Rosser, Dailya Kancheva, Claire Vinel, Yau Mun Lim, Nicola Pomella, Xinyu Zhang, Loredana Guglielmi, Denise Sheer, Michael Barnes, Sebastian Brandner, Sven Nelander, Kiavash Movahedi, Silvia Marino
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c90e61c2aaf7947f492d1616ad1a63d
https://doi.org/10.7554/elife.77335.sa2
https://doi.org/10.7554/elife.77335.sa2