Rapid Lymphatic Dissemination of Encapsulated Group A Streptococci via Lymphatic Vessel Endothelial Receptor-1 Interaction.

Autor: Nicola N Lynskey, Suneale Banerji, Louise A Johnson, Kayla A Holder, Mark Reglinski, Peter A C Wing, David Rigby, David G Jackson, Shiranee Sriskandan

Publikováno v: PLoS Pathogens, Vol 11, Iss 9, p e1005137 (2015)

The host lymphatic network represents an important conduit for pathogen dissemination. Indeed, the lethal human pathogen group A streptococcus has a predilection to induce pathology in the lymphatic system and draining lymph nodes, however the underl

Externí odkaz: https://doaj.org/article/53dd3fe8d8ca4781884062489bb9ec8c

Methylome-dependent transformation of emm1 group A streptococci

Autor: Joana Alves, Joshua D. Rand, Alix B. E. Johnston, Connor Bowen, Nicola N. Lynskey

Publikováno v: mBio, Vol 14, Iss 4 (2023)

ABSTRACT Genetic intractability presents a fundamental barrier to the manipulation of bacteria, hindering advancements in microbiological research. Group A Streptococcus (GAS), a lethal human pathogen currently associated with an unprecedented surge

Externí odkaz: https://doaj.org/article/062aa1ee6b4045769e419927d7f794d4

Structure of the Streptococcus pyogenes NAD + Glycohydrolase Translocation Domain and Its Essential Role in Toxin Binding to Oropharyngeal Keratinocytes

Autor: Michael R. Wessels, James J. Chou, Ian J Lichtenstein, Jorge J. Velarde, Nicola N Lynskey, Alessandro Piai

Publikováno v: J Bacteriol

The emergence and continued dominance of a Streptococcus pyogenes (group A Streptococcus, GAS) M1T1 clonal group is temporally correlated with acquisition of genomic sequences that confer high level expression of cotoxins streptolysin O (SLO) and NAD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8d271343a94b68714c85e9a3d2c863b
https://doi.org/10.1128/jb.00366-21

Extracellular bacterial lymphatic metastasis drives Streptococcus pyogenes systemic infection

Autor: Claire E. Turner, David A. Jackson, Kristin Krohn Huse, Shiranee Sriskandan, Kevin J. Woollard, Max Pearson, Nicola N. Lynskey, Louise A. Johnson, Matthew K. Siggins, Suneale Banerji, Lucy Lamb

Publikováno v: Siggins, M K, Lynskey, N N, Lamb, L E, Johnson, L A, Huse, K K, Pearson, M, Banerji, S, Turner, C E, Woollard, K, Jackson, D G & Sriskandan, S 2020, ' Extracellular bacterial lymphatic metastasis drives Streptococcus pyogenes systemic infection ', Nature Communications, vol. 11, no. 1, 4697, pp. 1-12 . https://doi.org/10.1038/s41467-020-18454-0
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)

Unassisted metastasis through the lymphatic system is a mechanism of dissemination thus far ascribed only to cancer cells. Here, we report that Streptococcus pyogenes also hijack lymphatic vessels to escape a local infection site, transiting through

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d262d1d3331984d733f0cf6f468907d2
https://www.pure.ed.ac.uk/ws/files/165572170/s41467_020_18454_0.pdf

Flow Cytometry-Based Assays to Quantify Complement Deposition and Neutrophil Uptake of Group A Streptococcus

Autor: Nicola N. Lynskey

Publikováno v: Methods in Molecular Biology ISBN: 9781071604663

Quantification of complement deposition and subsequent neutrophil-mediated uptake provides an important way to assess the role of different bacterial factors in evasion of the host innate immune response. Here, we describe flow cytometry-based method

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cb1e5e20f79de4b45c65a6cd9273f05f
https://doi.org/10.1007/978-1-0716-0467-0_17