Zobrazeno 1 - 10
of 125
pro vyhledávání: '"Nicola L. B. Pohl"'
Autor:
Chengxi Li, Alex J. Callahan, Mark D. Simon, Kyle A. Totaro, Alexander J. Mijalis, Kruttika-Suhas Phadke, Genwei Zhang, Nina Hartrampf, Carly K. Schissel, Ming Zhou, Hong Zong, Gunnar J. Hanson, Andrei Loas, Nicola L. B. Pohl, David E. Verhoeven, Bradley L. Pentelute
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
PMOs (phosphorodiamidate morpholino oligomers) have huge potential for antisense therapy but complex and slow synthesis limits application. Here, the authors report the development of automated flow synthesis methods which reduce nucleobase coupling
Externí odkaz:
https://doaj.org/article/b0ad40ceaf224d3c88e0a5f7d5670117
Autor:
Ashley E. DeYong, Alexander Zsikla, Clay S. Bennett, Tu-Anh V Nguyen, Olivea Vasquez, Subbarao Yalamanchili, John Florek, Nicola L. B. Pohl, Gavin Stamper
Publikováno v:
Angew Chem Int Ed Engl
An automated continuous flow system capable of producing protected deoxy-sugar donors from commercial material is described. Four 2,6-dideoxy and two 3-amino-2,3,6-trideoxy sugars with orthogonal protecting groups were synthesized in 11-32 % overall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8889c13f0771a02f83d4fecc02cee45a
https://doi.org/10.1002/ange.202109887
https://doi.org/10.1002/ange.202109887
Autor:
Genwei Zhang, Chengxi Li, Hong Zong, Nina Hartrampf, David Verhoeven, Carly K. Schissel, Gunnar J. Hanson, Alexander J. Mijalis, Bradley L. Pentelute, Kyle A. Totaro, Nicola L. B. Pohl, Kruttika-Suhas Phadke, Mark D. Simon, Andrei Loas, Ming Zhou, Alex J. Callahan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
Nature Communications
Nature Communications
Rapid development of antisense therapies can enable on-demand responses to new viral pathogens and make personalized medicine for genetic diseases practical. Antisense phosphorodiamidate morpholino oligomers (PMOs) are promising candidates to fill su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84864de28c18ba6617391f64d094c3b8
https://doaj.org/article/b0ad40ceaf224d3c88e0a5f7d5670117
https://doaj.org/article/b0ad40ceaf224d3c88e0a5f7d5670117
Publikováno v:
Pure and Applied Chemistry. 91:1243-1255
Carbohydrate structures are often complex. Unfortunately, synthesis of the range of sugar combinations precludes the use of a single coupling protocol or set of reagents. Adapting known, reliable bench-chemistry reactions to work via automation will
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fcd336b1d26a694aff18fb9032b644da
https://doi.org/10.1515/pac-2019-0307
https://doi.org/10.1515/pac-2019-0307
Publikováno v:
Comprehensive Glycoscience
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb524099d70937f359e31593ac516d82
https://doi.org/10.1016/b978-0-12-819475-1.00071-7
https://doi.org/10.1016/b978-0-12-819475-1.00071-7
Publikováno v:
The Journal of organic chemistry. 85(24)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c83049b0530a78fe543933515543f535
https://pubmed.ncbi.nlm.nih.gov/33334105
https://pubmed.ncbi.nlm.nih.gov/33334105
Autor:
Nicola L. B. Pohl, Sayantan Bhaduri, Robert J. Linhardt, Kevin H. Mayo, Chao Cai, Hans-Joachim Gabius, Michelle C. Miller, Kanin Wichapong
Publikováno v:
Scientific Reports
Scientific Reports, 10(1):15708. Nature Publishing Group
Scientific Reports, Vol 10, Iss 1, Pp 1-18 (2020)
Scientific Reports, 10(1):15708. Nature Publishing Group
Scientific Reports, Vol 10, Iss 1, Pp 1-18 (2020)
Glycosaminoglycan chains of keratan sulfate proteoglycans appear to be physiologically significant by pairing with tissue lectins. Here, we used NMR spectroscopy and molecular dynamics (MD) simulations to characterize interactions of corneal keratan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8e3fa4d32b0684970ad06c1ec21f0d8
http://europepmc.org/articles/PMC7515912
http://europepmc.org/articles/PMC7515912
Autor:
Fa Liu, Daniel E. K. Kabotso, Nicola L. B. Pohl, David L. Smiley, Richard D. DiMarchi, Vasily M. Gelfanov, Diego Perez-Tilve, John P. Mayer
Publikováno v:
Journal of medicinal chemistry. 63(11)
Native insulin is susceptible to biophysical aggregation and fibril formation, promoted by manual agitation and elevated temperatures. The safety of the drug and its application to alternative forms of administration could be enhanced through the ide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40eda704ffa3b22ac5f01718215eea34
https://pubmed.ncbi.nlm.nih.gov/32406685
https://pubmed.ncbi.nlm.nih.gov/32406685
Publikováno v:
Org Biomol Chem
An efficient, modular continuous flow process towards accessing two orthogonally protected glycals is described with the development of reaction conditions for several common protecting group additions in flow, including the addition of benzyl, napht
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45fb5e186f45442cdb08f333ea87a637
https://europepmc.org/articles/PMC7289173/
https://europepmc.org/articles/PMC7289173/
Autor:
Michael Boyce, Christoffer K. Goth, Ravi Kumar H. Veeraiah, Akul Y. Mehta, Robert Kardish, Melinda S. Hanes, Nicola L. B. Pohl, Chao Gao, Richard D. Cummings, Yasuyuki Matsumoto, Sucharita Dutta, Kathrin Stavenhagen, Jamie Heimburg-Molinaro
Publikováno v:
Cell Chem Biol
Glycan recognition is typically studied using free glycans, but glycopeptide presentations represent more physiological conditions for glycoproteins. To facilitate studies of glycopeptide recognition, we developed Glyco-SPOT synthesis, which enables
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f6e4c185646695fe85fd45facba7616
https://pubmed.ncbi.nlm.nih.gov/32610041
https://pubmed.ncbi.nlm.nih.gov/32610041