Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Nicola L Wilke"'
Autor:
Marie-C. Ahrweiler-Sawaryn, Animesh Biswas, Corazon Frias, Jerico Frias, Nicola L. Wilke, Nathalie Wilke, Albrecht Berkessel, Aram Prokop
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 161, Iss , Pp 114507- (2023)
Gold complexes could be promising for tumor therapy because of their cytotoxic and cytostatic properties. We present novel gold(I) complexes and clarify whether they also show antitumor activity by studying apoptosis induction in different tumor cell
Externí odkaz:
https://doaj.org/article/725cc077cfbe49f69f52e4a6bff9cc37
Autor:
Nicola L. Wilke, Liliane Onambele Abodo, Corazon Frias, Jerico Frias, Jennifer Baas, Michael A. Jakupec, Bernhard K. Keppler, Aram Prokop
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 156, Iss , Pp 113974- (2022)
Tris-(8-quinolinolato)gallium(III) (KP46, AP-002) is an orally administered investigational anticancer and bone-protective drug currently being evaluated in patients with advanced solid tumors with bone involvement. Despite the clinical efficacy of o
Externí odkaz:
https://doaj.org/article/4740f4597e774ddd835ae712fab53af0
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 2, p 952 (2023)
Ruthenium(II) complexes with N-heterocyclic carbene (NHC) ligands have recently attracted attention as novel chemotherapeutic agents. The complex HB324 was intensively studied as an apoptosis-inducing compound in resistant cell lines. HB324 induced a
Externí odkaz:
https://doaj.org/article/9213e151d29f4817806be6881c0a6498
Autor:
Nicola L Wilke, Qifang Wang, Nathalie Wilke, Marie Ahrweiler, Sina M. Hopff, Albrecht Berkessel, Aram Prokop, Corazon Frias
Publikováno v:
Journal of Cancer Research and Clinical Oncology
Purpose Since the discovery of the well-known cis-platin, transition metal complexes are highly recognized as cytostatic agents. However, toxic side effects of the metal ions present in the complexes may pose significant problems for their future dev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45e3a6c6302d7df4c6f4674c0d75706b
https://doi.org/10.1007/s00432-021-03679-3
https://doi.org/10.1007/s00432-021-03679-3
Autor:
Robert M. Reich, Corazon Frias, Tânia S. Morais, Marcel König, Marie Ahrweiler, Fritz E. Kühn, Jonas F. Schlagintweit, Eva‐Maria H. J. Esslinger, Christian H. G. Jakob, Nicola L Wilke, Fernanda Marques, João Franco Machado, Jerico Frias, Aram Prokop, João D. G. Correia
Publikováno v:
Journal of medicinal chemistry. 64(21)
The synthesis and antiproliferative activity of Mes- and iPr-substituted gold(I) bis(1,2,3-triazol-5-ylidene) complexes in various cancer cell lines are reported, showing nanomolar IC50 values of 50 nM (lymphoma cells) and 500 nM (leukemia cells), re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5fc983623881573e47735462b6986ae
https://pubmed.ncbi.nlm.nih.gov/34670090
https://pubmed.ncbi.nlm.nih.gov/34670090