Zobrazeno 1 - 10
of 122
pro vyhledávání: '"Nicola J. Stonehouse"'
Autor:
Mohammad W. Bahar, Veronica Nasta, Helen Fox, Lee Sherry, Keith Grehan, Claudine Porta, Andrew J. Macadam, Nicola J. Stonehouse, David J. Rowlands, Elizabeth E. Fry, David I. Stuart
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
Cryo-EM structures reveal the role of glutathione (GSH) in poliovirus (PV) serotype 3 virus-like particle (VLP) stability, suggesting GSH or an analogous tight-binding antiviral offers potential for stabilizing VLP vaccines against PV.
Externí odkaz:
https://doaj.org/article/0d5db9da35ca49d08e79312c5f1dc633
Autor:
Natalie J. Kingston, Keith Grehan, Joseph S. Snowden, Mark Hassall, Jehad Alzahrani, Guido C. Paesen, Lee Sherry, Connor Hayward, Amy Roe, Sam Stephen, Darren Tomlinson, Antra Zeltina, Katie J. Doores, Neil A. Ranson, Martin Stacey, Mark Page, Nicola J. Rose, Thomas A. Bowden, David J. Rowlands, Nicola J. Stonehouse
Publikováno v:
mSphere, Vol 8, Iss 1 (2023)
ABSTRACT Having varied approaches to the design and manufacture of vaccines is critical in being able to respond to worldwide needs and newly emerging pathogens. Virus-like particles (VLPs) form the basis of two of the most successful licensed vaccin
Externí odkaz:
https://doaj.org/article/b7c301ef9e3a4446bd7a97505024123b
Autor:
Lee Sherry, Jessica J. Swanson, Keith Grehan, Huijun Xu, Mai Uchida, Ian M. Jones, Nicola J. Stonehouse, David J. Rowlands
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 1 (2023)
ABSTRACT The production of enterovirus virus-like particles (VLPs) that lack the viral genome have great potential as vaccines for a number of diseases, such as poliomyelitis and hand, foot, and mouth disease. These VLPs can mimic empty capsids, whic
Externí odkaz:
https://doaj.org/article/83e091e831884d0a9588bca688904466
Autor:
Eleni-Anna Loundras, James Streetley, Morgan R. Herod, Rebecca Thompson, Mark Harris, David Bhella, Nicola J. Stonehouse
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
Loundras et al. report on the fibril components of the RNA-dependent RNA polymerase RdRp from foot-and-mouth disease virus. They demonstrate that higher-order fibril-based interactions create multiple complex structures within which RNA replication c
Externí odkaz:
https://doaj.org/article/fd0cabf965964352a52c576ea4715475
Autor:
Natalie J. Kingston, Keith Grehan, Joseph S. Snowden, Mona Shegdar, Helen Fox, Andrew J. Macadam, David J. Rowlands, Nicola J. Stonehouse
Publikováno v:
mSphere, Vol 7, Iss 3 (2022)
ABSTRACT Enterovirus A71 (EVA71) is a medically important virus that is commonly associated with hand, foot, and mouth disease (HFMD). It is responsible for periodic outbreaks, resulting in significant economic impact and loss of life. Vaccination of
Externí odkaz:
https://doaj.org/article/2ef97b3af6e44c7293cd043c6395f5a8
Autor:
Joseph S. Snowden, Jehad Alzahrani, Lee Sherry, Martin Stacey, David J. Rowlands, Neil A. Ranson, Nicola J. Stonehouse
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Type I fatty acid synthases (FASs) are critical metabolic enzymes which are common targets for bioengineering in the production of biofuels and other products. Serendipitously, we identified FAS as a contaminant in a cryoEM dataset of virus-
Externí odkaz:
https://doaj.org/article/ea134c6e98c5470c870f579a6a29ef67
Autor:
Mohammad W. Bahar, Veronica Nasta, Helen Fox, Lee Sherry, Keith Grehan, Claudine Porta, Andrew J. Macadam, Nicola J. Stonehouse, David J. Rowlands, Elizabeth E. Fry, David I. Stuart
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/747ed033b5d14c2baff8e310a56a1ac0
Autor:
Lee Sherry, Keith Grehan, Jessica J. Swanson, Mohammad W. Bahar, Claudine Porta, Elizabeth E. Fry, David I. Stuart, David J. Rowlands, Nicola J. Stonehouse
Publikováno v:
Viruses, Vol 14, Iss 10, p 2159 (2022)
Following the success of global vaccination programmes using the live-attenuated oral and inactivated poliovirus vaccines (OPV and IPV), wild poliovirus (PV) is now only endemic in Afghanistan and Pakistan. However, the continued use of these vaccine
Externí odkaz:
https://doaj.org/article/d8131386c99946418b17811bbf258c55
Autor:
Kunmei Liu, Dantong Hong, Fan Zhang, Xin Li, Meng He, Xuebo Han, Guolin Zhang, Guangxian Xu, Nicola J. Stonehouse, Zhongjia Jiang, Weijun An, Le Guo
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Autophagy is a key element of innate immune response against invading pathogens including Mycobacterium tuberculosis (M. tuberculosis). The emerging roles of microRNAs in regulating host antimicrobial responses against M. tuberculosis have gained wid
Externí odkaz:
https://doaj.org/article/310fdaa8f0fe4258a6a527499080cfc1
Autor:
Lee Sherry, Keith Grehan, Joseph S. Snowden, Michael L. Knight, Oluwapelumi O. Adeyemi, David J. Rowlands, Nicola J. Stonehouse
Publikováno v:
mSphere, Vol 5, Iss 2 (2020)
ABSTRACT For enteroviruses such as poliovirus (PV), empty capsids, which are antigenically indistinguishable from mature virions, are produced naturally during viral infection. The production of such capsids recombinantly, in heterologous systems suc
Externí odkaz:
https://doaj.org/article/488d04d86fa140579e59ec88d5d3ee47