Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Nicola J. Rolley"'
Autor:
Claire M. Hull, Andrew G. S. Warrilow, Nicola J. Rolley, Claire L. Price, Iain S. Donnison, Diane E. Kelly, Steven L. Kelly
Publikováno v:
Biotechnology for Biofuels, Vol 10, Iss 1, Pp 1-13 (2017)
Abstract Background Bioethanol production from sustainable sources of biomass that limit effect on food production are needed and in a biorefinery approach co-products are desirable, obtained from both the plant material and from the microbial biomas
Externí odkaz:
https://doaj.org/article/447f5c1a20cc49d59e1d991615012368
Autor:
Claire L Price, Andrew G S Warrilow, Nicola J Rolley, Josie E Parker, Vera Thoss, Diane E Kelly, Nicolae Corcionivoschi, Steven L Kelly
Publikováno v:
PLoS ONE, Vol 17, Iss 3, p e0265227 (2022)
The cytochrome P450 CYP168A1 from Pseudomonas aeruginosa was cloned and expressed in Escherichia coli followed by purification and characterization of function. CYP168A1 is a fatty acid hydroxylase that hydroxylates saturated fatty acids, including m
Externí odkaz:
https://doaj.org/article/0c90bb703fce45e4b14eb43700b54656
Autor:
Claire L. Price, Josie E. Parker, Andrew G. S. Warrilow, Nicola J. Rolley, Diane E. Kelly, Steven L. Kelly, W. David Nes
Here we report the first evaluation of isavuconazole inhibition of Aspergillus fumigatus CYP51 and thus sterol biosynthesis in the fungus. Voriconazole and isavuconazole both bound tightly to recombinant A. fumigatus CYP51 isoenzymes A and B (AfCYP51
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::734c9c869bd5a4847d6d3585cfaff6d5
https://cronfa.swan.ac.uk/Record/cronfa51096/Download/0051096-09082019123922.pdf
https://cronfa.swan.ac.uk/Record/cronfa51096/Download/0051096-09082019123922.pdf
Autor:
Steven L. Kelly, Josie E. Parker, Andrew G. S. Warrilow, Nicola J. Rolley, Claire M. Hull, Stephen N. Smith, Diane E. Kelly, W. David Nes
Publikováno v:
Applied and Environmental Microbiology. 80:6154-6166
A candidate CYP51 gene encoding sterol 14α-demethylase from the fish oomycete pathogen Saprolegnia parasitica (SpCYP51) was identified based on conserved CYP51 residues among CYPs in the genome. It was heterologously expressed in Escherichia coli ,
Autor:
Christopher J. Smyrniotis, Diane E. Kelly, Theodore R. Holman, Andrew G. S. Warrilow, David D. Hughes, Claire L. Price, Josie E. Parker, Nicola J. Rolley, Vera Thoss, Steven L. Kelly, W. David Nes
Publikováno v:
Scientific Reports
Malassezia globosa cytochromes P450 CYP51 and CYP5218 are sterol 14α-demethylase (the target of azole antifungals) and a putative fatty acid metabolism protein (and a potential azole drug target), respectively. Lanosterol, eburicol and obtusifoliol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::893eb523ad7ede097eb7c167ad43c913
https://cronfa.swan.ac.uk/Record/cronfa34335
https://cronfa.swan.ac.uk/Record/cronfa34335
Autor:
Andrew G. S. Warrilow, Josie E. Parker, Colin J. Jackson, S. M. Morris, Steven L. Kelly, Iain Donnison, Carolyn Greig, Nicola J. Rolley, Claire M. Martel, Diane E. Kelly
Publikováno v:
Bioresource Technology. 102:1503-1508
This study demonstrates use of recombinant yeast to simultaneously saccharify and ferment grass juice (GJ) to bioethanol. A modified Bacillus subtilis levanase gene (sacC) in which the native bacterial signal sequence was replaced with a yeast α-fac
Autor:
Nicola J. Rolley, Michael Weig, Andrew G. S. Warrilow, Claire M. Martel, Josie E. Parker, Uwe Gross, Steven L. Kelly, Diane E. Kelly, Oliver Bader
Publikováno v:
Antimicrobial Agents and Chemotherapy. 54:4527-4533
Sterol analysis identified four Candida albicans erg3 mutants in which ergosta 7,22-dienol, indicative of perturbations in sterol Δ 5,6 -desaturase (Erg3p) activity, comprised >5% of the total sterol fraction. The erg3 mutants (CA12, CA488, CA490, a
Autor:
Diane E. Kelly, Claire M. Martel, Nicola J. Rolley, Andrew G. S. Warrilow, Josie E. Parker, Steven L. Kelly
Publikováno v:
Antimicrobial Agents and Chemotherapy. 54:4920-4923
Azoles are used for treatment of Aspergillus infections (11, 13) and also in prophylactic drug regimens for immunocompromised patients (8). The emergence (4, 14, 30, 31, 32) and potential for spread (2) of azole-resistant Aspergillus (hereafter focus
Autor:
Josie E. Parker, Steven L. Kelly, Diane E. Kelly, David C. Lamb, Nicola J. Rolley, Stephen N. Smith, W. David Nes, Andrew G. S. Warrilow
In this study, we investigate the amebicidal activities of the pharmaceutical triazole CYP51 inhibitors fluconazole, itraconazole, and voriconazole against Acanthamoeba castellanii and Acanthamoeba polyphaga and assess their potential as therapeutic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2ab346f1ae0699f5cb36cfbcea5e2bc
https://cronfa.swan.ac.uk/Record/cronfa31514
https://cronfa.swan.ac.uk/Record/cronfa31514
Autor:
Nicola J. Rolley, Claire M. Hull, Iain Donnison, Steven L. Kelly, Diane E. Kelly, Edric Joel Loveridge
Publikováno v:
Biotechnology for Biofuels
Background:\ud Genetically customised\ud Saccharomyces cerevisiae\ud that can produce ethanol and additional bio-based\ud chemicals from sustainable agro-industrial feedstocks (for example, residual plant biomass) are of major interest to\ud the biof
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dd1aaa0f8449286a2ef60492a82c78a
https://cronfa.swan.ac.uk/Record/cronfa18617
https://cronfa.swan.ac.uk/Record/cronfa18617