Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Nicola J. Rogers"'
Publikováno v:
Chemical Science
Naturally occurring peptides in many living systems perform antimicrobial and anticancer host defence roles, but their potential for clinical application is limited by low metabolic stability and relatively high costs of goods. Self-assembled helical
Autor:
Hana Kostrhunova, Roger M. Phillips, Hannah E. Bridgewater, Samantha L. Shepherd, Simon J. Allison, Nicola J. Rogers, Viktor Brabec, Jana Kasparkova, Jitka Pracharova, Vojtech Novohradsky, Peter Scott, Hualong Song
Publikováno v:
Angewandte Chemie (International Ed. in English)
Monosaccharides are added to the hydrophilic face of a self‐assembled asymmetric FeII metallohelix, using CuAAC chemistry. The sixteen resulting architectures are water‐stable and optically pure, and exhibit improved antiproliferative selectivity
Autor:
Jitka Pracharova, Ondrej Hrabina, Hana Kostrhunova, Jaroslav Malina, Viktor Brabec, Peter Scott, Vojtech Novohradsky, Daniel H. Simpson, Nicola J. Rogers
Publikováno v:
Inorganic Chemistry. 59:3304-3311
The water-compatible optically pure metallohelices made by self-assembly of simple nonpeptidic organic components around Fe(II) ions are now recognized as a distinct subclass of helicates that exhibit similar architecture to some natural cationic ant
Autor:
Miles Postings, Samantha L. Shepherd, Roger M. Phillips, Peter Scott, Viktor Brabec, Guy J. Clarkson, Hana Kostrhunova, Nicola J. Rogers, Hualong Song, James P. C. Coverdale
Publikováno v:
Chemical Communications. 56:6392-6395
Functionalised triazole aldehydes are used in the highly selective self-assembly of water-compatible, optically pure, low symmetry Fe(ii)- and Zn(ii)-based metallohelices. Sub-micromolar antiproliferative activity is observed against various cancerou
Autor:
Matthew J. Winter, Tetsuhiro Kudoh, Nicola J. Rogers, Charles R. Tyler, Aya Takesono, John Moreman, Alexis Perry, Maciej Trznadel, Mark E. Wood
Publikováno v:
Environmental Science & Technology. 52:6656-6665
Environmental exposure to Bisphenol A (BPA) has been associated with a range of adverse health effects, including on the cardiovascular system in humans. Lack of agreement on its mechanism(s) of action likely stem from comparisons between in vivo and
Autor:
Andrei S. Batsanov, Dmitry S. Yufit, Ilya Kuprov, David Parker, Juan A. Aguilar, Kevin Mason, Nicola J. Rogers, Elizaveta A. Suturina
Publikováno v:
Inorganic chemistry, 2017, Vol.56(7), pp.4028-4038 [Peer Reviewed Journal]
Ytterbium and yttrium complexes of octadentate ligands based on 1,4,7,10-tetraazacyclododecane with a coordinated pyridyl group and either tricarboxylate (L1) or triphosphinate (L2) donors form twisted-square-antiprismatic structures. The former crys
Autor:
Simon J. Allison, Nicola J. Rogers, Hualong Song, Peter Scott, Lenka Markova, Roger M. Phillips, Juraj Zajac, Emma Pinder, Hana Kostrhunova, Viktor Brabec, Hannah E. Bridgewater, Samantha L. Shepherd, Lawrence S. Young
Helicates and related metallofoldamers, synthesised by dynamic self-assembly, represent an area of chemical space inaccessible by traditional organic synthesis, and yet with potential for discovery of new classes of drug. Here we report that water-so
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5999c9e29faf5f3ce9847a56ab1b5d4f
http://wrap.warwick.ac.uk/123991/1/WRAP-discovery-selective-antimetastatic-anti-cancer-stem-cell-post-Scott-2019.pdf
http://wrap.warwick.ac.uk/123991/1/WRAP-discovery-selective-antimetastatic-anti-cancer-stem-cell-post-Scott-2019.pdf
Autor:
Viktor Brabec, David I. Roper, Jaroslav Malina, Andrew D. Millard, Peter Scott, Nicola J. Rogers, Gemma L. Kay, Nicholas R. Waterfield, David J. Fox, Alexia Hapeshi, Ondrej Hrabina, Guy J. Clarkson, Hualong Song, John Moat, Andrew K. King, Daniel H. Simpson
Publikováno v:
Chemical Science
Iron-based self-assembled optically pure compounds mimic the mechanisms of small peptides, according to biophysical, genomic, transcriptomic and other analyses.
A range of new water-compatible optically pure metallohelices – made by self-assem
A range of new water-compatible optically pure metallohelices – made by self-assem
Paramagnetic metal ions with anisotropic magnetic susceptibilities can shift the proton NMR signals of chelating ligands beyond the diamagnetic range of endogenous proton resonances. Such large shifts, along with enhanced longitudinal relaxation rate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0232fb00bfffb1008e4ebd596a08fdd4
http://wrap.warwick.ac.uk/115869/7/WRAP-employing-paramagnetic-shift-responsive-probes-Rogers-2019.pdf
http://wrap.warwick.ac.uk/115869/7/WRAP-employing-paramagnetic-shift-responsive-probes-Rogers-2019.pdf
Publikováno v:
Plastics and the Environment ISBN: 9781788012416
In this chapter we discuss the current understanding on chemical exposures and effects in wildlife for phthalates, the most widely used plasticisers, and two other major components of plastics, bisphenol A (BPA) – a plastic monomer and polybrominat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2b7f1162b1298616579208007ff4a68
https://doi.org/10.1039/9781788013314-00106
https://doi.org/10.1039/9781788013314-00106