Výsledky vyhledávání - "Nicola J. Leech"

Dendritic cell-based assays, but not mannosylation of antigen, improves detection of T-cell responses to proinsulin in type 1 diabetes

Autor: Colin M. Dayan, Parth Narendran, Wallace M. Macindoe, Nicola J. Leech, KA Elsegood, Geert-Jan Boons

Publikováno v: Immunology. 111:422-429

In vitro detection of T-cell responses to autoantigens in type 1 diabetes is recognized as being technically challenging. We aimed to accurately measure cellular responses to proinsulin in patients with diabetes, and speculated that presentation of a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f3a5a7b4014f3ae165854ca243c04d1
https://doi.org/10.1111/j.1365-2567.2004.01825.x

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Humoral and cellular immune responses to proinsulin in adults with newly diagnosed type 1 diabetes

Autor: Parth Narendran, Colin M. Dayan, Alistair J K Williams, Nicola J. Leech, KA Elsegood

Publikováno v: Diabetes/Metabolism Research and Reviews. 19:52-59

Background: Type 1 diabetes (T1D) is an autoimmune disease characterized by immunity against pancreatic islet-derived proteins. The object of this study was to measure antibody and T-cell responses against proinsulin (PI), an islet-derived protein, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fc713052881ef5c25c5f8187bb9f2b7
https://doi.org/10.1002/dmrr.332

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Successful Prospective Prediction of Type 1 Diabetes in Schoolchildren Through Multiple Defined Autoantibodies

Autor: Michael S. Brantley, Rachel E. Rowe, Nicola J. Leech, James M. LaGasse, David K. McCulloch, Gerald T. Nepom, Stephanie A. Monks, Jerry P. Palmer, William Hagopian

Publikováno v: Diabetes Care. 25:505-511

OBJECTIVE—Almost 90% of type 1 diabetes appears in individuals without a close family history. We sought to evaluate the best current predictive strategy, multiple defined autoantibodies, in a long-term prospective study in the general population.R

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::035ffdb4ed5bc8c36a7651ce0d87cf3c
https://doi.org/10.2337/diacare.25.3.505

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High Genetic Risk for IDDM in the Pacific Northwest: First Report From the Washington State Diabetes Prediction Study

Autor: Rachel E. Rowe, David K. McCulloch, Gerald T. Nepom, Nicola J. Leech

Publikováno v: Diabetes. 43:87-94

A Combination Of Immune, genetic, and metabolic markers potentially implicated in the development of insulin-dependent diabetes mellitus (IDDM) was studied in the general population. We screened 3,992 healthy schoolchildren, 12–18 years of age with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::379417b8b7ca802193628a9dd8bf6224
https://doi.org/10.2337/diab.43.1.87

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Dendritic cell-based proliferative assays of peripheral T cell responses to tetanus toxoid

Autor: Nicola J. Leech, KA Elsegood, Colin M. Dayan, Parth Narendran

Publikováno v: Annals of the New York Academy of Sciences. 958

Antigen-specific proliferative responses of peripheral blood T cells are widely used in humans to study the T cell compartment. However, responses to autoantigens are often weak and poorly reproducible. Here we show, using a test recall antigen (teta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d2c988f157a93cba67f93b221a53371
https://pubmed.ncbi.nlm.nih.gov/12021100

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Genetic and immunological markers of insulin dependent diabetes in Black Americans

Autor: George A. Burghen, Jerry P. Palmer, Gerald T. Nepom, Nicola J. Leech, Lakshmi K. Gaur, James W. Hansen, Abbas E. Kitabchi, William Hagopian

Publikováno v: Autoimmunity. 22(1)

ICA and GAD65 autoantibody profiles and HLA-DR and DQ analysis were performed on 43 Black juvenile onset IDDM patients and 34 unrelated Black controls from Tennessee, USA. 75% of patients were positive for GAD65 autoantibodies but only 53% had ICA; 3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f86496719a3b91e3ce3e7dd00a4e1573
https://pubmed.ncbi.nlm.nih.gov/8882419

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Retrograde versus antegrade cannulation in the intravenous glucose tolerance test

Autor: David K. McCulloch, D.T. Finegood, Rachel E. Rowe, Nicola J. Leech

Publikováno v: Diabetes research and clinical practice. 25(2)

To investigate whether drawing blood from a retrogradely cannulated hand vein rather than an antegradely cannulated arm vein improves reproducibility in the intravenous tolerance test (IVGTT) we compared these two methods directly by drawing blood fr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5616c6a8a580d8dc12d28fc3966673e
https://pubmed.ncbi.nlm.nih.gov/7821192

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Children with type-1 diabetes and their unaffected siblings have few er symptoms of asthma

Autor: Hilary A Gillmor, Nicola J Leech, I. F. Douek, Polly J. Bingley, Edwin A M Gale

Publikováno v: The Lancet. 353:1850

We wanted to establish whether the reduced risk of asthma in children with diabetes had a genetic basis or was in some way related to the diabetic phenotype. Control data for the frequency of symptoms associated with asthma and other atopic condition

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fccb96d649dc5da44ecbd5ca6ef3e4b5
https://doi.org/10.1016/s0140-6736(99)00988-5

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