Structure and Interactions of the TPR Domain of Sgt2 with Yeast Chaperones and Ybr137wp

Autor: Ewelina M. Krysztofinska, Nicola J. Evans, Arjun Thapaliya, James W. Murray, Rhodri M. L. Morgan, Santiago Martinez-Lumbreras, Rivka L. Isaacson

Publikováno v: Frontiers in Molecular Biosciences, Vol 4 (2017)

Small glutamine-rich tetratricopeptide repeat-containing protein 2 (Sgt2) is a multi-module co-chaperone involved in several protein quality control pathways. The TPR domain of Sgt2 and several other proteins, including SGTA, Hop, and CHIP, is a high

Externí odkaz: https://doaj.org/article/fa831935d71b41519e0ed81dc0364b1e

An improved surveillance measure for adolescent smoking?

Autor: Arthur J. Farkas, Elizabeth A. Gilpin, John P. Pierce, Nicola J Evans

Publikováno v: Pierce, JP; Farkas, A; Evans, N; & Gilpin, E. (2017). An improved surveillance measure for adolescent smoking?. Tobacco Control. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/14z9s357
Tobacco Control, vol 4, iss Suppl 1

Objective To assess the possible usefulness and validity of a new measure to identify adolescents at risk of smoking cigarettes. Design The new measure was compared with standard ones with respect to their ability to identify young adolescents at ris

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7c43506a98d6300f1a66ec3263d1a1a
http://www.escholarship.org/uc/item/14z9s357

A High-Throughput Screening Triage Workflow to Authenticate a Novel Series of PFKFB3 Inhibitors

Autor: Ian M. Hardern, Jarrod Walsh, Ed Wheatley, Jon Winter-Holt, Sarita Maman, Judit E. Debreczeni, Graeme Walker, Susan E. Critchlow, Gareth M. Davies, Nicola J. Evans, Richard A. Ward, Neil P. Jones, Sheila B. McLoughlin, Andrew Peter Thomas, Neil Bennett, Geoff Holdgate, Nicola Curtis, Stephen A. St-Gallay, Lindsey Leach, Laurent Rigoreau, Andrew P. Turnbull, Marian Preston

Publikováno v: SLAS discovery : advancing life sciences RD. 23(1)

A high-throughput screen (HTS) of human 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) resulted in several series of compounds with the potential for further optimization. Informatics was used to identify active chemotypes with lead-l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbb293272e1c04a39e000a87f72a6166
https://pubmed.ncbi.nlm.nih.gov/28945981

SGTA interacts with the proteasomal ubiquitin receptor Rpn13 via a carboxylate clamp mechanism

Autor: Santiago Martínez-Lumbreras, Isabelle L. Terry, Nicola J. Evans, Rivka L. Isaacson, Arjun Thapaliya, Ewelina M. Krysztofinska, Yvonne Nyathi, Stephen High

Publikováno v: Thapaliya, A, Nyathi, Y, Martinez Lumbreras, S, Krysztofinska, E, Evans, N, Terry, I L, High, S & Isaacson, R L 2016, ' SGTA interacts with the proteasomal ubiquitin receptor Rpn13 via a carboxylate clamp mechanism ', Scientific Reports, vol. 6, 36622 . https://doi.org/10.1038/srep36622
Scientific Reports

The fate of secretory and membrane proteins that mislocalize to the cytosol is decided by a collaboration between cochaperone SGTA (small, glutamine-rich, tetratricopeptide repeat protein alpha) and the BAG6 complex, whose operation relies on multipl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d9973c1c2a73abba49351a59e4b4e32
https://kclpure.kcl.ac.uk/en/publications/464dc9fe-eeac-4f4d-876a-904299e8849e

How to Avoid Life Writing: Lessons from David Lynch

Autor: Nicola J Evans

Publikováno v: Life Writing. 8:399-409

For several years acclaimed director David Lynch phoned in regular weather reports to a community radio station in Los Angeles. The act pokes fun at an industry in which autobiographical exploitation of star directors and name-brand authors has becom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::550f51d357d7cea2fb8f4977519b6368
https://doi.org/10.1080/14484528.2011.619714