Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Nicola J. Borthwick"'
Autor:
Yehia S. Mohamed, Nicola J. Borthwick, Nathifa Moyo, Hayato Murakoshi, Tomohiro Akahoshi, Francesca Siliquini, Zara Hannoun, Alison Crook, Peter Hayes, Patricia E. Fast, Gaudensia Mutua, Walter Jaoko, Sandra Silva-Arrieta, Anuska Llano, Christian Brander, Masafumi Takiguchi, Tomáš Hanke
Publikováno v:
Vaccines, Vol 8, Iss 2, p 260 (2020)
Sub-Saharan Africa carries the biggest burden of the human immunodeficiency virus type 1 (HIV-1)/AIDS epidemic and is in an urgent need of an effective vaccine. CD8+ T cells are an important component of the host immune response to HIV-1 and may need
Externí odkaz:
https://doaj.org/article/153ce30639e44cfdbf69e802818a6554
Autor:
Nicola J Borthwick, Thirusha Lane, Nathifa Moyo, Alison Crook, Jung Min Shim, Ian Baines, Edmund G Wee, Philip N Hawkins, Julian D Gillmore, Tomáš Hanke, Mark B Pepys
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0197299 (2018)
BACKGROUND:The failure of DNA vaccination in humans, in contrast to its efficacy in some species, is unexplained. Observational and interventional experimental evidence suggests that DNA immunogenicity may be prevented by binding of human serum amylo
Externí odkaz:
https://doaj.org/article/7a2fa7f9bc0c42c7b0828285a71cde8e
Autor:
Nathifa Moyo, Nicola J Borthwick, Edmund G Wee, Silvia Capucci, Alison Crook, Lucy Dorrell, Tomáš Hanke
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0181382 (2017)
BackgroundDurability of vaccine-elicited immune responses is one of the key determinants for vaccine success. Our aim is to develop a vaccination strategy against the human immunodeficiency virus type 1 (HIV-1), which induces protective and durable C
Externí odkaz:
https://doaj.org/article/4fcb067b367c485b9493ed69f86e688f
Autor:
Gaudensia Mutua, Bashir Farah, Robert Langat, Jackton Indangasi, Simon Ogola, Brian Onsembe, Jakub T Kopycinski, Peter Hayes, Nicola J Borthwick, Ambreen Ashraf, Len Dally, Burc Barin, Annika Tillander, Jill Gilmour, Jan De Bont, Alison Crook, Drew Hannaman, Josephine H Cox, Omu Anzala, Patricia E Fast, Marie Reilly, Kundai Chinyenze, Walter Jaoko, Tomáš Hanke
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 3, Iss C (2016)
We are developing a pan-clade HIV-1 T-cell vaccine HIVconsv, which could complement Env vaccines for prophylaxis and be a key to HIV cure. Our strategy focuses vaccine-elicited effector T-cells on functionally and structurally conserved regions (not
Externí odkaz:
https://doaj.org/article/4f123ec4f6fe44898924201105e4aa3e
Autor:
Yehia S, Mohamed, Nicola J, Borthwick, Nathifa, Moyo, Hayato, Murakoshi, Tomohiro, Akahoshi, Francesca, Siliquini, Zara, Hannoun, Alison, Crook, Peter, Hayes, Patricia E, Fast, Gaudensia, Mutua, Walter, Jaoko, Sandra, Silva-Arrieta, Anuska, Llano, Christian, Brander, Masafumi, Takiguchi, Tomáš, Hanke
Publikováno v:
Vaccines
Sub-Saharan Africa carries the biggest burden of the human immunodeficiency virus type 1 (HIV-1)/AIDS epidemic and is in an urgent need of an effective vaccine. CD8+ T cells are an important component of the host immune response to HIV-1 and may need
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::762dfa3808ba33e1fc4de4a0ec0588dd
https://pubmed.ncbi.nlm.nih.gov/32485938
https://pubmed.ncbi.nlm.nih.gov/32485938
Autor:
Francis G Gabriel, Martine J. Jager, Penny Johnson, Marta E Polak, D McCormick, Ian A. Cree, Bernard Higgins, Jeremy Hurren, Nicola J Borthwick
Publikováno v:
British Journal of Cancer
Cutaneous melanoma is highly immunogenic, yet primary melanomas and metastases develop successfully in otherwise immunocompetent patients. To investigate the local immunosuppressive microenvironment, we examined the presence of suppressor T lymphocyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5efdd133cdfdffff15606229fbedcdee
https://doi.org/10.1038/sj.bjc.6603763
https://doi.org/10.1038/sj.bjc.6603763
Autor:
Martine J. Jager, John L. Hungerford, Marta E Polak, Bernard Higgins, Ian A. Cree, Silvana Di Palma, Nicola J Borthwick, Penny Johnson
Publikováno v:
British Journal of Ophthalmology. 91:971-976
Background: Uveal melanoma arises in an immune-privileged site and can itself add to the immunosuppressive environment. Previous studies on cutaneous melanoma have shown the presence of tolerogenic dendritic cells (DCs), which could play an important
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16c884498c6afafb8f4058180af33ee2
https://doi.org/10.1136/bjo.2006.110908
https://doi.org/10.1136/bjo.2006.110908
Autor:
Nicola J, Borthwick, Maximillian, Rosario, Torben, Schiffner, Emma, Bowles, Tina, Ahmed, Peter, Liljeström, Guillaume E, Stewart-Jones, Jan W, Drijfhout, Cornelis J M, Melief, Tomáš, Hanke
Publikováno v:
Immunity, Inflammation and Disease
Vaccines delivering T cell immunogen HIVconsv vectored by plasmid DNA, non-replicating simian adenovirus and non-replicating modified vaccinia virus Ankara (MVA) are under clinical evaluation in phase I/IIa trials in UK, Europe, and Africa. While the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ebb800aafee701c14f7059c57d41afcd
https://pubmed.ncbi.nlm.nih.gov/26029368
https://pubmed.ncbi.nlm.nih.gov/26029368
Autor:
Maria Vieira, D. Soares, Nicola J. Borthwick, Mala K. Maini, George Janossy, Mike Salmon, Arne N. Akbar
Publikováno v:
The Journal of Immunology. 161:5909-5917
We have investigated the regulation of adult and cord blood CD45RA+ T cell proliferation and apoptosis to identify factors that may control the naive T cell pool. Cord CD45RA+ T cells were highly susceptible to spontaneous apoptosis as compared with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26613accc53c684474803413567d236e
https://doi.org/10.4049/jimmunol.161.11.5909
https://doi.org/10.4049/jimmunol.161.11.5909
Autor:
Fiona A Riordan, Christopher A Bravery, Kamuran Mengubas, Nandita Ray, Nicola J Borthwick, Arne N Akbar, Steven M Hart, A Victor Hoffbrand, Atul B Mehta, R Gitendra Wickremasinghe
Publikováno v:
Oncogene. 16:1533-1542
Philadelphia chromosome (Ph)-positive leukaemia cells express the chimeric bcr/abl oncoprotein, whose deregulated protein tyrosine kinase (PTK) activity antagonizes the induction of apoptosis by DNA damaging agents, Treatment of Ph-positive K562, TOM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::073f026a8c02832653df6db5a30d2a3f
https://doi.org/10.1038/sj.onc.1201680
https://doi.org/10.1038/sj.onc.1201680