Výsledky vyhledávání - "Nicola J. Barber"

Characterization of the hydrolytic activity of a polyclonal catalytic antibody preparation by pH-dependence and chemical modification studies: evidence for the involvement of Tyr and Arg side chains as hydrogen-bond donors

Autor: Roberta Vigna, Eleni Hagi-Pavli, Chandra S. Verma, Aaron B. Watts, Gerard Gallacher, Keith Brocklehurst, Caroline S. Simms, Marina Resmini, Nicola J. Barber

Publikováno v: Biochemical Journal. 326:279-287

The hydrolyses of 4-nitrophenyl 4′-(3-aza-2-oxoheptyl)phenyl carbonate and of a new, more soluble, substrate, 4-nitrophenyl 4′-(3-aza-7-hydroxy-2-oxoheptyl)phenyl carbonate, each catalysed by a polyclonal antibody preparation elicited in a sheep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad22df5b65217c30c06bcebfa86fb65c
https://doi.org/10.1042/bj3260279

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A rat monoclonal antibody that catalyses the hydrolysis of a nitrophenyl-beta-lactam

Autor: Keith Brocklehurst, Elizabeth L. Ostler, Guillaume Boucher, Nickolas Romanov, Nicola J. Barber, Maurizio Valeri, C. J. Dean, Marina Resmini, Gerard Gallacher, Stuart L. James

Publikováno v: Biochemical and biophysical research communications. 299(2)

We report the first example of a monoclonal antibody-catalysed hydrolysis of a beta-lactam where the antibodies were generated by a simple transition-state analogue. A rat monoclonal antibody (1/91c/4d/26) generated by using an acyclic 4-nitrophenylp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22417dd24870326047af74e6d2908f87
https://pubmed.ncbi.nlm.nih.gov/12437982

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