Zobrazeno 1 - 10
of 97
pro vyhledávání: '"Nicola J Smith"'
Autor:
Joshua Machet, Mijeong Park, Alexander Richardson, Michael Carnell, Margaret A Mouat, Nicola J Smith, Nigel Turner, Blake J Cochran, Kerry‐Anne Rye, Nick Di Girolamo
Publikováno v:
Journal of Diabetes Investigation, Vol 14, Iss 4, Pp 591-601 (2023)
Abstract Introduction The quantification of intraepithelial corneal basal nerve parameters by in vivo confocal microscopy represents a promising modality to identify the earliest manifestations of diabetic peripheral neuropathy. However, its diagnost
Externí odkaz:
https://doaj.org/article/97976652a6524ec8becf296b04fdb5d4
Autor:
Meghna Sobti, Robert Ishmukhametov, James C Bouwer, Anita Ayer, Cacang Suarna, Nicola J Smith, Mary Christie, Roland Stocker, Thomas M Duncan, Alastair G Stewart
Publikováno v:
eLife, Vol 8 (2019)
ATP synthase produces the majority of cellular energy in most cells. We have previously reported cryo-EM maps of autoinhibited E. coli ATP synthase imaged without addition of nucleotide (Sobti et al. 2016), indicating that the subunit ε engages the
Externí odkaz:
https://doaj.org/article/8558cc0057474eebbfd4ff399bbc2669
Autor:
Nicola J Smith
Publikováno v:
Frontiers in Pharmacology, Vol 6 (2015)
Orphan G protein-coupled receptors (GPCRs) represent a largely untapped resource for the treatment of a variety of diseases, despite sophisticated advances in drug discovery. Two promising orphan GPCRs are the endothelin B receptor-like proteins, GPR
Externí odkaz:
https://doaj.org/article/9a7a07608c664995b281a38f1793acc4
Autor:
James L. J. Coleman, Karen eBrennan, Tony eNgo, Poornima eBalaji, Robert M. Graham, Nicola J Smith
Publikováno v:
Frontiers in Endocrinology, Vol 6 (2015)
As little as a decade ago, generation of a single knockout mouse line was an expensive and time-consuming undertaking available to relatively few researchers. The International Knockout Mouse Consortium, established in 2007, has revolutionized the us
Externí odkaz:
https://doaj.org/article/47796ed3547d4e1bba0fd4384e43edcc
Autor:
Ze-Yan Yu, Ju-Chiat Tan, Aisling C McMahon, Siiri E Iismaa, Xiao-Hui Xiao, Scott H Kesteven, Melissa E Reichelt, Marion C Mohl, Nicola J Smith, Diane Fatkin, David Allen, Stewart I Head, Robert M Graham, Michael P Feneley
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e99024 (2014)
To determine the mechanisms by which the α1A-adrenergic receptor (AR) regulates cardiac contractility.We reported previously that transgenic mice with cardiac-restricted α1A-AR overexpression (α1A-TG) exhibit enhanced contractility but not hypertr
Externí odkaz:
https://doaj.org/article/7cf2975340e84d309efedf580a689349
Autor:
Nicola J Smith
Publikováno v:
Frontiers in Endocrinology, Vol 3 (2012)
The discovery that a number of metabolic intermediates can act through G protein-coupled receptors has attracted great interest in the field and has led to new therapeutic targets for a variety of diseases such as hypertension, type 2 diabetes, infla
Externí odkaz:
https://doaj.org/article/9d950d3638614ed4b6ee471c9894669e
Autor:
Christina A. Bursill, Nicola J. Smith, Nathan Palpant, Isabella Tan, Margaret Sunde, Richard P. Harvey, Benjamin Lewis, Gemma A. Figtree, Jamie I. Vandenberg
Publikováno v:
Heart, Lung and Circulation. 31:1321-1332
Despite significant advances in interventional and therapeutic approaches, cardiovascular disease (CVD) remains the leading cause of death and mortality. To lower this health burden, cardiovascular discovery scientists need to play an integral part i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eae9945db455cab0e93d04729ccbea58
https://doi.org/10.1016/j.hlc.2022.06.669
https://doi.org/10.1016/j.hlc.2022.06.669
Publikováno v:
Trends in Endocrinology & Metabolism. 33:481-492
Atherosclerosis predisposes to myriad cardiovascular complications, including myocardial infarction and stroke. Statins have revolutionised cholesterol management but they do not work for all patients, particularly those with familial hypercholestero
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b101d61a6a748fa2aa0c8e6fe2e0a108
https://doi.org/10.1016/j.tem.2022.04.008
https://doi.org/10.1016/j.tem.2022.04.008
Autor:
Kinjal Patel, Nicola J. Smith
Publikováno v:
British Journal of Pharmacology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a68480ee85c054523119ba3870d4b8f
https://doi.org/10.1111/bph.16053
https://doi.org/10.1111/bph.16053
Autor:
Brooke W. Purdue, Melissa E. Reichelt, David J. Pennisi, Enzo R. Porrello, Nicola J. Smith, Giovanna Gambarotta, Zhen Wang, Hsiu-Wen Chan, Shannon L. O'Brien, Walter G. Thomas, Tamara M. Paravicini
Publikováno v:
Journal of Cellular Physiology. 236:8160-8170
Epidermal growth factor (EGF) receptors (ErbB1-ErbB4) promote cardiac development and growth, although the specific EGF ligands and receptor isoforms involved in growth/repair versus pathology remain undefined. We challenged ventricular cardiomyocyte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6fe3c5a27edc0ce52327a2899bf8a4e
https://doi.org/10.1002/jcp.30487
https://doi.org/10.1002/jcp.30487