Truly‐Biocompatible Gold Catalysis Enables Vivo‐Orthogonal Intra‐CNS Release of Anxiolytics

Autor: M. Carmen Ortega‐Liebana, Nicola J. Porter, Catherine Adam, Teresa Valero, Lloyd Hamilton, Dirk Sieger, Catherina G. Becker, Asier Unciti‐Broceta

Publikováno v: Ortega Liebana, M C, Porter, N, Adam, C, Valero Grinan, T M, Hamilton, L, Sieger, D, Becker, C & Unciti-Broceta, A 2021, ' Truly-biocompatible gold catalysis enables vivo-orthogonal intra-CNS release of anxiolytics ', Angewandte Chemie . https://doi.org/10.1002/ange.202111461, https://doi.org/10.1002/ange.202111461
Angewandte Chemie-International Edition

Being recognized as the best-tolerated of all metals, the catalytic potential of gold (Au) has thus far been hindered by the ubiquitous presence of thiols in organisms. Herein we report the development of a truly-catalytic Au-polymer composite by ass

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2608f7afb1fac5d47d3ff0dc20d9b952
https://doi.org/10.1002/ange.202111461

CRISPR gRNA phenotypic screening in zebrafish reveals pro-regenerative genes in spinal cord injury

Autor: David A. Lyons, Themistoklis M. Tsarouchas, Catherina G. Becker, Thomas Becker, Hui-Hsin Tsai, Juan Larraz, Davide Gianni, Tahimina Munir, Marcus Keatinge, Nicola J. Porter

Publikováno v: PLoS Genetics, Vol 17, Iss 4, p e1009515 (2021)
PLoS Genetics

Zebrafish exhibit robust regeneration following spinal cord injury, promoted by macrophages that control post-injury inflammation. However, the mechanistic basis of how macrophages regulate regeneration is poorly understood. To address this gap in un

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c9f2e00cacb7fb7e9f1d67c3a37a637
https://doaj.org/article/ebb1d8e5ba6e43a49ae28bb01edfb043