Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Nicola J Lee"'
Publikováno v:
Molecular Metabolism, Vol 76, Iss , Pp 101790- (2023)
Objective: One of leptin's main targets in the hypothalamus are neuropeptide Y (NPY) neurons, with selective deletion of leptin receptors (Lepr) specifically in Npy neurons resulting in major alterations of energy partitioning between fat and bone ma
Externí odkaz:
https://doaj.org/article/8285223c4de5485298beef3c22249ded
Publikováno v:
Molecular Metabolism, Vol 59, Iss , Pp 101455- (2022)
Objective: Aguti-related protein (AGRP) neurons in the arcuate nucleus of the hypothalamus (ARC), which co-express neuropeptide Y (NPY), are key regulators of feeding and energy homeostasis. However, the precise role NPY has within these neurons and
Externí odkaz:
https://doaj.org/article/a41d88dd87914f0eb24d5e3e9010718e
Autor:
Lei Zhang, Chi Kin Ip, I-Chieh J. Lee, Yue Qi, Felicia Reed, Tim Karl, Jac Kee Low, Ronaldo F. Enriquez, Nicola J. Lee, Paul A. Baldock, Herbert Herzog
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-19 (2018)
Excess caloric intake leads to increased thermogenesis in brown adipose tissue, to limit weight gain. Here, the authors show that neuropeptide FF receptor-2 signalling promotes thermogenesis via control of NPY expression in the arcuate nucleus, and t
Externí odkaz:
https://doaj.org/article/b4414e5490bc452aa201c298f2a70439
Publikováno v:
International Journal of Obesity. 46:1749-1758
Background/Objective Female mice are often excluded from diet-induced obesity studies as they are more resistant to the obesifying effects of a high-fat diet (HFD). However, the underlying mechanisms behind this sex disparity may actually have import
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c69577c24dc6a6367927b168b8778a3b
https://doi.org/10.1038/s41366-022-01174-4
https://doi.org/10.1038/s41366-022-01174-4
Publikováno v:
Cell Metabolism.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f3de72c54bc99ed5349b6c3d7df01a8
https://doi.org/10.1016/j.cmet.2023.04.020
https://doi.org/10.1016/j.cmet.2023.04.020
Autor:
Nicola J. Lee, Amy D. Nguyen, Ronaldo F. Enriquez, Jude Luzuriaga, Mohammed Bensellam, Ross Laybutt, Paul A. Baldock, Herbert Herzog
Publikováno v:
Molecular Metabolism, Vol 4, Iss 3, Pp 164-174 (2015)
Objective: The skeleton has recently emerged as an additional player in the control of whole-body glucose metabolism; however, the mechanism behind this is not clear. Methods: Here we employ mice lacking neuropeptide Y, Y1 receptors solely in cells o
Externí odkaz:
https://doaj.org/article/6408bae3d0e7442588fe06bc2bb6da23
Publikováno v:
American journal of physiology. Endocrinology and metabolism. 323(3)
We provide novel evidence that OGN and LCN2 decrease 120 min after ingesting a high-glucose mixed-nutrient meal in healthy adults. Acute aerobic exercise increases circulating LCN2 for up to 3-h postexercise, whereas circulating OGN remains similar t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10580ec86946b4b784cfd76cefb2e502
https://pubmed.ncbi.nlm.nih.gov/35767699
https://pubmed.ncbi.nlm.nih.gov/35767699
Autor:
Ee-Cheng Khor, Bruce Fanshawe, Yue Qi, Sergei Zolotukhin, Rishikesh N Kulkarni, Ronaldo F Enriquez, Louise Purtell, Nicola J Lee, Natalie K Wee, Peter I Croucher, Lesley Campbell, Herbert Herzog, Paul A Baldock
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0148155 (2016)
Prader-Willi Syndrome (PWS), a maternally imprinted disorder and leading cause of obesity, is characterised by insatiable appetite, poor muscle development, cognitive impairment, endocrine disturbance, short stature and osteoporosis. A number of caus
Externí odkaz:
https://doaj.org/article/707580c41569469e85e0b7d18109c9b5
Autor:
Chi Kin Ip, Natalie K.Y. Wee, Ronaldo F. Enriquez, Paul A. Baldock, Nicola J. Lee, Herbert Herzog, Yue Qi, Ireni Clarke
Publikováno v:
International Journal of Obesity. 44:2149-2164
Maintaining energy balance is important to ensure a healthy organism. However, energy partitioning, coordinating the distribution of sufficient energy to different organs and tissues is equally important, but the control of this process is largely un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9d9e13846559975f3e6675f8b0078ad
https://doi.org/10.1038/s41366-020-0550-6
https://doi.org/10.1038/s41366-020-0550-6
Publikováno v:
Journal of Neuroendocrinology. 33
The central nervous system is an active and major regulator of bone structure and remodelling. Specifically, signalling within the hypothalamus has been shown to be critical to ensuring that skeletal functions align with whole body metabolic supply a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b890bb3f51e360f49a2ebef7482ad68
https://doi.org/10.1111/jne.12978
https://doi.org/10.1111/jne.12978