Zobrazeno 1 - 10
of 415
pro vyhledávání: '"Nicola J, Robertson"'
Autor:
Hemmen Sabir, Elke Maes, Margit Zweyer, Yvonne Schleehuber, Farhad B. Imam, Jared Silverman, Yasmine White, Raymand Pang, Anca M. Pasca, Nicola J. Robertson, Emin Maltepe, Maria E. Bernis
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Intrapartum hypoxia–ischemia leading to neonatal encephalopathy (NE) results in significant neonatal mortality and morbidity worldwide, with > 85% of cases occurring in low- and middle-income countries (LMIC). Therapeutic hypothermia (HT)
Externí odkaz:
https://doaj.org/article/0b4133575d944984a9e37a8a0281e7e8
Autor:
Raymand Pang, Hyun Jee Han, Christopher Meehan, Xavier Golay, Suzanne L. Miller, Nicola J. Robertson
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 9, Iss 6, Pp 795-809 (2022)
Abstract Objective Neonatal encephalopathy (NE) is an important cause of mortality and disability worldwide. Therapeutic hypothermia (HT) is an effective therapy, however not all babies benefit. Novel agents are urgently needed to improve outcomes. M
Externí odkaz:
https://doaj.org/article/99a40a9d22dc4baf96de503e29f4c02d
Autor:
Vinita Verma, Frederic Lange, Alan Bainbridge, Kelly Harvey-Jones, Nicola J. Robertson, Ilias Tachtsidis, Subhabrata Mitra
Publikováno v:
Frontiers in Pediatrics, Vol 10 (2022)
Brain tissue temperature is a dynamic balance between heat generation from metabolism, passive loss of energy to the environment, and thermoregulatory processes such as perfusion. Perinatal brain injuries, particularly neonatal encephalopathy, and se
Externí odkaz:
https://doaj.org/article/4458399b3f164d3b96c48e3db82512cf
Autor:
Silke Häusler, Nicola J. Robertson, Klervi Golhen, John van den Anker, Katie Tucker, Thomas K. Felder
Publikováno v:
Antioxidants, Vol 12, Iss 8, p 1630 (2023)
Despite significant improvements in survival following preterm birth in recent years, the neurodevelopmental burden of prematurity, with its long-term cognitive and behavioral consequences, remains a significant challenge in neonatology. Neuroprotect
Externí odkaz:
https://doaj.org/article/b2fbbe7ebfd8478da6ae70917c39a3e0
Publikováno v:
Frontiers in Pediatrics, Vol 10 (2022)
Cellular and tissue damage triggered after hypoxia-ischemia (HI) can be generalized and affect the neurogenic niches present in the central nervous system. As neuroregeneration may be critical for optimizing functional recovery in neonatal encephalop
Externí odkaz:
https://doaj.org/article/bfd91e26dfd3483fa00da68b81725c8f
Autor:
Sean R Mathieson, Emily L Webb, Moffat Nyirenda, Nicola J Robertson, J Mugalu, Guillaume Gilbert, A Nabawanuka, Kathryn Martinello, J Bwambale, Samson Lubowa, Alan Bainbridge, H Ssebombo, Latha Srinivasan, Cornelia Hagmann, Cathy Morgan, Pia Wintermark, Frances M Cowan, Cally J Tann, Geraldine B Boylan, Annettee Nakimuli, Samantha Sadoo, Carol Nanyunja, Michael Kawooya, Ivan Mambule, Kirsty Le Doare
Publikováno v:
Gates Open Research, Vol 6 (2022)
BACKGROUND: Neonatal encephalopathy (NE) is a leading cause of child mortality worldwide and contributes substantially to stillbirths and long-term disability. Ninety-nine percent of deaths from NE occur in low-and-middle-income countries (LMICs). Wh
Externí odkaz:
https://doaj.org/article/c957083d915c472e989fec5d4110fe6d
Autor:
Denis Azzopardi, Andrew T. Chew, Aniko Deierl, Angela Huertas, Nicola J. Robertson, Nora Tusor, A. David Edwards
Publikováno v:
EBioMedicine, Vol 47, Iss , Pp 484-491 (2019)
Background: The TOBY-Xe proof of concept randomised trial found no effect of xenon combined with hypothermia after birth asphyxia on the lactate to N-acetyl aspartate ratio (Lac/NAA) in the thalamus and fractional anisotropy (FA) in white matter trac
Externí odkaz:
https://doaj.org/article/38889f0804e2461f88133a0fff66c807
Autor:
Nicola J. Robertson, Kathryn Martinello, Ingran Lingam, Adnan Avdic-Belltheus, Christopher Meehan, Daniel Alonso-Alconada, Sara Ragab, Alan Bainbridge, Magdalena Sokolska, Mohamed Tachrount, Benita Middleton, David Price, Mariya Hristova, Xavier Golay, Annamaria Soliani Raschini, Giancarlo Aquino, Nicola Pelizzi, Fabrizio Facchinetti
Publikováno v:
Neurobiology of Disease, Vol 121, Iss , Pp 240-251 (2019)
Therapeutic hypothermia is only partially protective for neonatal encephalopathy; there is an urgent need to develop treatments that augment cooling. Our objective was to assess safety, efficacy and pharmacokinetics of 5 and 15 mg/kg/24 h melatonin (
Externí odkaz:
https://doaj.org/article/7daf6abf1444477d8d26b24a12891d49
Publikováno v:
Frontiers in Pediatrics, Vol 9 (2021)
Neonatal encephalopathy (NE) in term and near-term infants is a significant global health problem; the worldwide burden of disease remains high despite the introduction of therapeutic hypothermia. Assessment of injury severity and effective managemen
Externí odkaz:
https://doaj.org/article/f130f8484e04410eb7bc0aaa89244952
Autor:
Raymand Pang, Kathryn A. Martinello, Christopher Meehan, Adnan Avdic-Belltheus, Ingran Lingam, Magda Sokolska, Tatenda Mutshiya, Alan Bainbridge, Xavier Golay, Nicola J. Robertson
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
Despite therapeutic hypothermia, survivors of neonatal encephalopathy have high rates of adverse outcome. Early surrogate outcome measures are needed to speed up the translation of neuroprotection trials. Thalamic lactate (Lac)/N-acetylaspartate (NAA
Externí odkaz:
https://doaj.org/article/cb3c1094922b43c5b22938f1f1897e34