Biochemical, clinical and genetic characteristics in adults with persistent hypophosphatasaemia; Data from an endocrinological outpatient clinic in Denmark

Autor: Nicola Hepp, Anja Lisbeth Frederiksen, Morten Duno, Jakob Præst Holm, Niklas Rye Jørgensen, Jens-Erik Beck Jensen

Publikováno v: Bone Reports, Vol 15, Iss , Pp 101101- (2021)

Background: Hypophosphatasia (HPP) is an inborn disease caused by pathogenic variants in ALPL. Low levels of alkaline phosphatase (ALP) are a biochemical hallmark of the disease. Scarce knowledge about the prevalence of HPP in Scandinavia exists, and

Externí odkaz: https://doaj.org/article/4c3b9cdc0b7e4128b51268f4bf5e9186

The Antiresorptive Effect of GIP, But Not GLP‐2, Is Preserved in Patients With Hypoparathyroidism—A Randomized Crossover Study

Autor: Nicola Hepp, Morten Frost, Jannika Oeke, Mette M. Rosenkilde, Morten Steen Hansen, Jens Erik Beck Jensen, Sten Madsbad, Nariman Balenga, Bolette Hartmann, Abbas Jafari, Maria S. Svane, John A. Olson, Jens J. Holst, Moustapha Kassem, Kirsa Skov-Jeppesen

Publikováno v: Journal of Bone and Mineral Research
Skov-Jeppesen, K, Hepp, N, Oeke, J, Hansen, M S, Jafari, A, Svane, M S, Balenga, N, Olson, J A, Frost, M, Kassem, M, Madsbad, S, Beck Jensen, J E, Holst, J J, Rosenkilde, M M & Hartmann, B 2021, ' The Antiresorptive Effect of GIP, But Not GLP-2, Is Preserved in Patients With Hypoparathyroidism—A Randomized Crossover Study ', Journal of Bone and Mineral Research, vol. 36, no. 8, pp. 1448-1458 . https://doi.org/10.1002/jbmr.4308
Skov-Jeppesen, K, Hepp, N, Oeke, J, Hansen, M S, Jafari, A, Svane, M S, Balenga, N, Olson, J A, Frost, M, Kassem, M, Madsbad, S, Beck Jensen, J-E, Holst, J J, Rosenkilde, M M & Hartmann, B 2021, ' The antiresorptive effect of GIP, but not GLP-2, is preserved in patients with hypoparathyroidism-a randomized crossover study ', Journal of Bone and Mineral Research, vol. 36, no. 8, pp. 1448-1458 . https://doi.org/10.1002/jbmr.4308

Glucose‐dependent insulinotropic polypeptide (GIP) and glucagon‐like peptide‐2 (GLP‐2) are gut hormones secreted postprandially. In healthy humans, both hormones decrease bone resorption accompanied by a rapid reduction in parathyroid hormone

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cbdce51578509d4f7143dff8592ec24
http://europepmc.org/articles/PMC8338760

Biochemical, clinical and genetic characteristics in adults with persistent hypophosphatasaemia; Data from an endocrinological outpatient clinic in Denmark

Autor: Niklas Rye Jørgensen, Nicola Hepp, Anja Lisbeth Frederiksen, Morten Duno, Jakob Præst Holm, Jens-Erik Beck Jensen

Publikováno v: Bone Reports, Vol 15, Iss, Pp 101101-(2021)
Hepp, N, Frederiksen, A L, Duno, M, Præst Holm, J, Rye Jørgensen, N & Beck Jensen, J E 2021, ' Biochemical, clinical and genetic characteristics in adults with persistent hypophosphatasaemia; Data from an endocrinological outpatient clinic in Denmark ', Bone Reports, vol. 15, 101101 . https://doi.org/10.1016/j.bonr.2021.101101
Hepp, N, Frederiksen, A L, Duno, M, Præst Holm, J, Rye Jørgensen, N & Beck Jensen, J-E 2021, ' Biochemical, clinical and genetic characteristics in adults with persistent hypophosphatasaemia; Data from an endocrinological outpatient clinic in Denmark ', Bone Reports, vol. 15, 101101 . https://doi.org/10.1016/j.bonr.2021.101101
Bone Reports

Background Hypophosphatasia (HPP) is an inborn disease caused by pathogenic variants in ALPL. Low levels of alkaline phosphatase (ALP) are a biochemical hallmark of the disease. Scarce knowledge about the prevalence of HPP in Scandinavia exists, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aeef69748b443fcfbfeb4f75ee0e1f37
http://www.sciencedirect.com/science/article/pii/S2352187221003570

Attitudes and knowledge regarding referrals for bariatric surgery among Danish secondary healthcare providers: A national survey

Autor: Anna Julie Aavild Juhl, Nicola Hepp, B C Deepti, Claus B. Juhl, Charlotte Røn Stolberg, Anja F. Elliott, Kalyan Adhikari

Publikováno v: Elliott, A F, Deepti, B C, Stolberg, C R, Hepp, N, Juhl, A J A, Adhikari, K & Juhl, C B 2020, ' Attitudes and knowledge regarding referrals for bariatric surgery among Danish secondary healthcare providers : a national survey ', Clinical Obesity, vol. 10, no. 4, e12369 . https://doi.org/10.1111/cob.12369

Bariatric surgery induces significant and sustained weight loss and subsequently reduces obesity-related comorbidities. However, only a small percentage of patients with severe obesity undergo bariatric surgery in Denmark. There is limited knowledge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7989da8257b07cf20070fbe3fefe444
https://doi.org/10.1111/cob.12369

Multiple Fractures and Impaired Bone Fracture Healing in a Patient with Pycnodysostosis and Hypophosphatasia

Autor: Bente L. Langdahl, Poul Vedtofte, Klaus Hindsø, Hanne B Hove, Niklas Rye Jørgensen, Anja Lisbeth Frederiksen, Jens-Erik Beck Jensen, Morten Duno, Nicola Hepp

Publikováno v: Hepp, N, Frederiksen, A L, Dunø, M, Jørgensen, N R, Langdahl, B, Vedtofte, P, Hove, H B, Hindsø, K & Jensen, J-E B 2019, ' Multiple Fractures and Impaired Bone Fracture Healing in a Patient with Pycnodysostosis and Hypophosphatasia ', Calcified Tissue International, vol. 105, no. 6, pp. 681-686 . https://doi.org/10.1007/s00223-019-00605-1
Hepp, N, Frederiksen, A L, Dunø, M, Jørgensen, N R, Langdahl, B, Vedtofte, P, Hove, H B, Hindsø, K & Jensen, J E B 2019, ' Multiple Fractures and Impaired Bone Fracture Healing in a Patient with Pycnodysostosis and Hypophosphatasia ', Calcified Tissue International, vol. 105, no. 6, pp. 681-686 . https://doi.org/10.1007/s00223-019-00605-1
Hepp, N, Frederiksen, A L, Dunø, M, Jørgensen, N R, Langdahl, B L, Vedtofte, P, Hove, H B, Hindsø, K & Jensen, J-E B 2019, ' Multiple Fractures and Impaired Bone Fracture Healing in a Patient with Pycnodysostosis and Hypophosphatasia ', Calcified Tissue International, vol. 105, pp. 681-686 . https://doi.org/10.1007/s00223-019-00605-1

Pycnodysostosis (PYCD) is a rare recessive inherited skeletal disease, characterized by short stature, brittle bones, and recurrent fractures, caused by variants in the Cathepsin K encoding gene that leads to impaired osteoclast-mediated bone resorpt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49577725740a6cf124c0c53ddde89a42
https://pubmed.ncbi.nlm.nih.gov/31489468