Výsledky vyhledávání - "Nicola Hellen"

Akademický článek

P-selectin mobility undergoes a sol-gel transition as it diffuses from exocytosis sites into the cell membrane

Autor: Nicola Hellen, Gregory I. Mashanov, Ianina L. Conte, Sophie le Trionnaire, Victor Babich, Laura Knipe, Alamin Mohammed, Kazim Ogmen, Silvia Martin-Almedina, Katalin Török, Matthew J. Hannah, Justin E. Molloy, Tom Carter

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)

P-selectin recruits leucocytes to regions of blood vessel damage. Using single molecule imaging, we find newly secreted P-selectin spreads rapidly across the plasma membrane and then becomes immobilized and better-suited to leucocyte capture.

Externí odkaz: https://doaj.org/article/432e60a79f5b4b69a0d8124022f3c9bb

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Akademický článek

Transcriptional co‐activators YAP1–TAZ of Hippo signalling in doxorubicin‐induced cardiomyopathy

Autor: Tünde Berecz, Angela Yiu, Orsolya Vittay, Barbara Orsolits, Maxime Mioulane, Cristobal G. dosRemedios, Robin Ketteler, Bela Merkely, Ágota Apáti, Sian E. Harding, Nicola Hellen, Gabor Foldes

Publikováno v: ESC Heart Failure, Vol 9, Iss 1, Pp 224-235 (2022)

Abstract Aims Hippo signalling is an evolutionarily conserved pathway that controls organ size by regulating apoptosis, cell proliferation, and stem cell self‐renewal. Recently, the pathway has been shown to exert powerful growth regulatory activit

Externí odkaz: https://doaj.org/article/cfa42de32b8a4c7f89de595f9ce54f50

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Proteomic Analysis Reveals Temporal Changes in Protein Expression in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes In Vitro

Autor: Nicola Hellen, Sian E. Harding, Gail Whiting, Karine Vauchez, Carolina P. Ricardo, Jun X. Wheeler

Publikováno v: Stem Cells and Development. 28:565-578

Human induced pluripotent stem cell-derived cardiomyocytes hold great promise for regenerative medicine and in vitro screening. Despite displaying key cardiomyocyte phenotypic characteristics, they more closely resemble foetal/neonatal cardiomyocytes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::719dace185fc09875b44ef7e7a163ab6
https://doi.org/10.1089/scd.2018.0210

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P-selectin mobility undergoes a sol-gel transition as it diffuses from exocytosis sites into the cell membrane

Publikováno v: Nature communications. 13(1)

In response to vascular damage, P-selectin molecules are secreted onto the surface of cells that line our blood vessels. They then serve as mechanical anchors to capture leucocytes from the blood stream. Here, we track individual P-selectin molecules

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e62fcd2184d31de1b188a7882415ef57
https://pubmed.ncbi.nlm.nih.gov/35641503

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Interaction between MyRIP and the actin cytoskeleton regulates Weibel–Palade body trafficking and exocytosis

Autor: Ianina Conte, Nicola Hellen, Nikolai I. Kiskin, Matthew J. Hannah, Ruben Bierings, Jean-Baptiste Manneville, Justin E. Molloy, Gregory I. Mashanov, Tom Carter

Publikováno v: Journal of Cell Science
Journal of Cell Science (JCS)

Weibel–Palade body (WPB)–actin interactions are essential for the trafficking and secretion of von Willebrand factor; however, the molecular basis for this interaction remains poorly defined. Myosin Va (MyoVa or MYO5A) is recruited to WPBs by a R

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d519003af23f6354ebadc556e4ab023
http://europepmc.org/articles/PMC4760305

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P19 Low levels of the A3243G MTDNA mutation in human induced pluripotent stem cell-cardiomyocytes do not cause functional or metabolic disturbances but increase with further passaging

Autor: Carolina P. Ricardo, Thusharika Kodagoda, Gabor Foldes, Nicola Hellen, Cesare M. Terracciano, S E Harding, Duchen

Publikováno v: Abstracts.

The heteroplasmic mtDNA mutation A3243G can cause the mitochondrial condition MELAS. Mitochondrial replacement therapy can prevent transmission of mtDNA mutations to offspring but to maintain nuclear integrity, a certain amount of cytoplasm and mutat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4a5d605b15c107fd8b91312795775e32
https://doi.org/10.1136/heartjnl-2018-bscr.24

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Action Potential Morphology of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Does Not Predict Cardiac Chamber Specificity and Is Dependent on Cell Density

Autor: David T.M. Du, Nicola Hellen, Christopher J. Kane, Cesare M. Terracciano

Publikováno v: Biophysical Journal. 108:1-4

Previous studies investigating human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) have proposed the distinction of heart chamber-specific (atrial, ventricular, pacemaker) electrophysiological phenotypes based on action potential (A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eed20b5fbf10d9ba1f0e4697ff05a08
https://doi.org/10.1016/j.bpj.2014.11.008

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Induced pluripotent stem cell modelling of HLHS underlines the contribution of dysfunctional NOTCH signalling to impaired cardiogenesis

Publikováno v: Human Molecular Genetics

Hypoplastic left heart syndrome (HLHS) is among the most severe forms of congenital heart disease. Although the consensus view is that reduced flow through the left heart during development is a key factor in the development of the condition, the mol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5bae3cae0d35705fa6300bcc79342ec7
https://pubmed.ncbi.nlm.nih.gov/28521042

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The Fallacy of Assigning Chamber Specificity to iPSC Cardiac Myocytes from Action Potential Morphology

Autor: Christopher Kane, David T.M. Du, Nicola Hellen, Cesare M. Terracciano

Publikováno v: Biophysical journal. 110(1)

The production and identification of chamber-specific, induced pluripotent stem cell-derived cardiac myocytes (iPSC-CMs) is a crucial step in the application of this technology in physiology, pharmacology, and regenerative studies. The significance o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::960e49e02f89620dc31d2b5d1057327d
https://pubmed.ncbi.nlm.nih.gov/26745430

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G-protein Coupled Receptor Signaling in Pluripotent Stem Cell-derived Cardiovascular Cells: Implications for Disease Modeling

Autor: Nazanin F, Dolatshad, Nicola, Hellen, Richard J, Jabbour, Sian E, Harding, Gabor, Földes

Publikováno v: Frontiers in Cell and Developmental Biology

Human pluripotent stem cell derivatives show promise as an in vitro platform to study a range of human cardiovascular diseases. A better understanding of the biology of stem cells and their cardiovascular derivatives will help to understand the stren

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3a6f86d7eff5088bdfcc142b9452db69
https://pubmed.ncbi.nlm.nih.gov/26697426

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