Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Nicola Fanto"'
Autor:
Claudio Sette, Maria M. Rosado, Maria Loiarro, Nicola Fanto, Eleonora Nucera, Elisabetta Cortis, Federica Capolunghi, Grazia Gallo, Barbara Ruggiero, Rita Carsetti, Simona Cascioli, Elia Girolami, Rita De Santis, Antonella Insalaco, Vito Ruggiero, Marina Vivarelli, Silvia Bordasco
Publikováno v:
Rheumatology. 49:2281-2289
Objectives. Toll-like receptor 9 (TLR9), which recognizes hypomethylated DNA [cytosine-phosphate-guanine (CpG)], plays a role in the maintenance of serological memory and has been recently implicated in the pathogenesis of SLE. We previously reported
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43af2637026dcef3ef8c42c8e904e68d
https://doi.org/10.1093/rheumatology/keq226
https://doi.org/10.1093/rheumatology/keq226
Autor:
Silvia Campo, Federica Capolunghi, Claudio Sette, Nicola Fanto, Maria Loiarro, Rita De Santis, Vito Ruggiero, Paolo Carminati, Brunilde Arseni, Grazia Gallo, Rita Carsetti
Publikováno v:
Journal of Leukocyte Biology. 82:801-810
MyD88 is an adaptor protein, which plays an essential role in the intracellular signaling elicited by IL-1R and several TLRs. Central to its function is the ability of its Toll/IL-1R translation initiation region (TIR) domain to heterodimerize with t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee39200ec2259332b89a8b679b46420e
https://doi.org/10.1189/jlb.1206746
https://doi.org/10.1189/jlb.1206746
Autor:
Ferdinando Maria Milazzo, Walter Cabri, Silvia Rivara, Gianfranco Battistuzzi, Maurizio Taddei, Daniele Pala, Giuseppe Giannini, Marco Mor, Marcella Barbarino, Mose Santaniello, Loredana Vesci, Nicola Fanto, Davide Vignola, Mario B. Guglielmi, Claudio Pisano
A systematic study of medicinal chemistry aimed at identifying a new generation of HDAC inhibitors, through the introduction of a thiol zinc-binding group (ZBG) and of an amide-lactam in the ω-position of the polyethylene chain of the vorinostat sca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::463c0217af12aea0df5893d36eec877c
http://hdl.handle.net/11585/756748
http://hdl.handle.net/11585/756748
Autor:
Rita De Santis, Paolo Carminati, Grazia Gallo, Claudio Sette, Nicola Fanto, Vito Ruggiero, Maria Loiarro
MyD88 couples the activation of the Toll-like receptors and interleukin-1 receptor superfamily with intracellular signaling pathways. Upon ligand binding, activated receptors recruit MyD88 via its Toll-interleukin-1 receptor domain. MyD88 then allows
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b884a2a7f05f5208949ee9ade3d9d0f1
http://hdl.handle.net/2108/39119
http://hdl.handle.net/2108/39119
Autor:
Marica Sassano, Davide Vignola, Vito Ruggiero, M.G. Quaglia, Giancarlo Basile, M. Pia Zibella, Rita De Santis, Mauro Semproni, Domenico Mastroianni, Andrea Ciacci, Paolo Carminati, Nicola Fanto, Valentina Bombardi, Grazia Gallo
Publikováno v:
Journal of medicinal chemistry. 51(5)
We describe the design and synthesis of a peptidomimetic library derived from the heptapeptide Ac-RDVLPGT-NH 2, belonging to the Toll/IL-1 receptor (TIR) domain of the adaptor protein MyD88 and effective in inhibiting its homodimerization. The abilit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e72b0eb91724eced13456c71b007907
https://pubmed.ncbi.nlm.nih.gov/18275134
https://pubmed.ncbi.nlm.nih.gov/18275134
Autor:
Paolo Carminati, Andrea Ciacci, Grazia Gallo, Nicola Fanto, Domenico Mastroianni, Claudio Sette, Vito Ruggiero, Maria Loiarro
Myeloid differentiation factor 88 (MyD88) plays a crucial role in the signaling pathways triggered by interleukin (IL)-1 and Toll-like receptors in several steps of innate host defense. A crucial event in this signaling pathway is represented by dime
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::073ab9414dde92102a1c37ef9f35c70c
http://hdl.handle.net/2108/39049
http://hdl.handle.net/2108/39049