Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Nicola F. Smith"'
Autor:
Sridhar Mani, William D. Figg, Susan E. Bates, Nicola F. Smith, Alex Sparreboom, Kazuto Yasuda, Erin G. Schuetz, Tristan M. Sissung
Publikováno v:
Annals of Pharmacotherapy. 44:1709-1717
Background: Several microtubule targeting agents are capable of inducing CYP3A4 via activation of the pregnane X receptor (PXR; NR1I2). Objective: To evaluate the CYP3A4 induction potential of vinblastine both clinically and in vitro and determine th
Publikováno v:
Molecular Cancer Therapeutics. 6:428-440
Pharmacokinetic evaluation is an essential component of drug discovery and should be conducted early in the process so that those compounds with the best chance of success are prioritized and progressed. However, pharmacokinetic analysis has become a
Autor:
Akinobu Hamada, William D. Figg, Jaap Verweij, Klaus Mross, Howard L. McLeod, Steven Marsh, Alex Sparreboom, Nicola F. Smith, TJ Scott-Horton, Stephan Mielke
Publikováno v:
Clinical Pharmacology & Therapeutics, 81(1), 76-82. Wiley-Blackwell
To explore retrospectively the relationships between paclitaxel pharmacokinetics and three known, non-synonymous single-nucleotide polymorphisms (SNPs) in SLCO1B3, the gene encoding organic anion transporting polypeptide (OATP)1B3. Accumulation of [(
Publikováno v:
Current Drug Metabolism. 7:677-685
Despite its controversial past, thalidomide is currently under investigation for the treatment of several disease types, ranging from inflammatory conditions to cancer. The mechanism of action of thalidomide is complex and not yet fully understood, b
Autor:
Jaap Verweij, Paul W. Schenk, Nicola F. Smith, Erin R. Lepper, Sharyn D. Baker, George Cusatis, Nicole Ries, William D. Figg, Danielle Ahn, Douglas K. Price, Ron H.J. Mathijssen, Susan E. Bates, Roxann G. Ingersoll, Alex Sparreboom, Matthew G. Permenter, Ron H.N. van Schaik
Publikováno v:
Clinical Cancer Research, 11(20), 7398-7404. American Association for Cancer Research Inc.
Purpose: To evaluate the effect of naturally occurring variants in genes encoding the cytochrome P450 (CYP) isoforms CYP3A4 and CYP3A5 in patients with cancer receiving midazolam as a phenotyping probe. Experimental Design: Five variants in CYP3A4 an
Autor:
Nicola F. Smith, Tony Kouzarides, Lindsay Stimson, Andrew J. Bannister, Paul Workman, Paul Rogers, Martin G. Rowlands, G. Wynne Aherne, Florence I. Raynaud, Michael Jarman, Vassilios Bavetsias, Yvette Newbatt, Stephen Gorsuch, Edward McDonald
Publikováno v:
Molecular Cancer Therapeutics. 4:1521-1532
Histone acetylation plays an important role in regulating the chromatin structure and is tightly regulated by two classes of enzyme, histone acetyltransferases (HAT) and histone deacetylases (HDAC). Deregulated HAT and HDAC activity plays a role in t
Publikováno v:
Expert Opinion on Drug Metabolism & Toxicology. 1:429-445
Members of the organic anion transporting polypeptide (OATP) family are responsible for the cellular uptake of a broad range of endogenous compounds and xenobiotics in multiple tissues. This review focuses on OATP1B1 and -1B3, which are specifically
Publikováno v:
Cancer Biology & Therapy. 4:815-818
Interindividual variability in paclitaxel and docetaxel pharmacokinetics, toxicity and response is extensive, and largely unexplained. We hypothesized that this is due to affinity of taxanes for an uptake transporter that indirectly regulates elimina
Publikováno v:
Cancer Chemotherapy and Pharmacology. 54:475-486
There is currently much interest in developing analogues of the benzoquinone ansamycin geldanamycin that may overcome the limitations of 17-(allylamino)-17-demethoxygeldanamycin (17AAG), which is the first known inhibitor of heat shock protein 90 (Hs
Publikováno v:
Drug Development Research. 62:233-253
A great deal of effort has been spent in defining the pharmacokinetics and pharmacodynamics of investigational and registered anticancer agents. There is often a marked variability in drug handling between individual patients, which contributes to va