Zobrazeno 1 - 10
of 284
pro vyhledávání: '"Nicola Elvassore"'
Cancer cell stiffening via CoQ10 and UBIAD1 regulates ECM signaling and ferroptosis in breast cancer
Autor:
Giovanni Tosi, Alessandro Paoli, Gaia Zuccolotto, Emilia Turco, Manuela Simonato, Daniela Tosoni, Francesco Tucci, Pietro Lugato, Monica Giomo, Nicola Elvassore, Antonio Rosato, Paola Cogo, Salvatore Pece, Massimo M. Santoro
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-24 (2024)
Abstract CoQ10 (Coenzyme Q10) is an essential fat-soluble metabolite that plays a key role in cellular metabolism. A less-known function of CoQ10 is whether it may act as a plasma membrane-stabilizing agent and whether this property can affect cancer
Externí odkaz:
https://doaj.org/article/fcdadd32e3c74c049a3cabd84a68dbf7
Hydrogel-in-hydrogel live bioprinting for guidance and control of organoids and organotypic cultures
Autor:
Anna Urciuolo, Giovanni Giuseppe Giobbe, Yixiao Dong, Federica Michielin, Luca Brandolino, Michael Magnussen, Onelia Gagliano, Giulia Selmin, Valentina Scattolini, Paolo Raffa, Paola Caccin, Soichi Shibuya, Dominic Scaglioni, Xuechun Wang, Ju Qu, Marko Nikolic, Marco Montagner, Gabriel L. Galea, Hans Clevers, Monica Giomo, Paolo De Coppi, Nicola Elvassore
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Three-dimensional hydrogel-based organ-like cultures can be applied to study development, regeneration, and disease in vitro. However, the control of engineered hydrogel composition, mechanical properties and geometrical constraints tends to
Externí odkaz:
https://doaj.org/article/8d949ed909e143ba8263b25ad3233dc1
Autor:
Francesco Panariello, Onelia Gagliano, Camilla Luni, Antonio Grimaldi, Silvia Angiolillo, Wei Qin, Anna Manfredi, Patrizia Annunziata, Shaked Slovin, Lorenzo Vaccaro, Sara Riccardo, Valentina Bouche, Manuela Dionisi, Marcello Salvi, Sebastian Martewicz, Manli Hu, Meihua Cui, Hannah Stuart, Cecilia Laterza, Giacomo Baruzzo, Geoffrey Schiebinger, Barbara Di Camillo, Davide Cacchiarelli, Nicola Elvassore
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Human cellular reprogramming to induced pluripotency is still an inefficient process, which has hindered studying the role of critical intermediate stages. Here we take advantage of high efficiency reprogramming in microfluidics and temporal
Externí odkaz:
https://doaj.org/article/4881a0e99d974abc86ba20b6cd9be0ad
Autor:
Flora Tassone, Dragana Protic, Emily Graves Allen, Alison D. Archibald, Anna Baud, Ted W. Brown, Dejan B. Budimirovic, Jonathan Cohen, Brett Dufour, Rachel Eiges, Nicola Elvassore, Lidia V. Gabis, Samantha J. Grudzien, Deborah A. Hall, David Hessl, Abigail Hogan, Jessica Ezzell Hunter, Peng Jin, Poonnada Jiraanont, Jessica Klusek, R. Frank Kooy, Claudine M. Kraan, Cecilia Laterza, Andrea Lee, Karen Lipworth, Molly Losh, Danuta Loesch, Reymundo Lozano, Marsha R. Mailick, Apostolos Manolopoulos, Veronica Martinez-Cerdeno, Yingratana McLennan, Robert M. Miller, Federica Alice Maria Montanaro, Matthew W. Mosconi, Sarah Nelson Potter, Melissa Raspa, Susan M. Rivera, Katharine Shelly, Peter K. Todd, Katarzyna Tutak, Jun Yi Wang, Anne Wheeler, Tri Indah Winarni, Marwa Zafarullah, Randi J. Hagerman
Publikováno v:
Cells, Vol 12, Iss 18, p 2330 (2023)
The premutation of the fragile X messenger ribonucleoprotein 1 (FMR1) gene is characterized by an expansion of the CGG trinucleotide repeats (55 to 200 CGGs) in the 5’ untranslated region and increased levels of FMR1 mRNA. Molecular mechanisms lead
Externí odkaz:
https://doaj.org/article/a0b6f75a833d4184b35d72147f86dffc
Autor:
Giovanni Giuseppe Giobbe, Francesco Bonfante, Brendan C. Jones, Onelia Gagliano, Camilla Luni, Elisa Zambaiti, Silvia Perin, Cecilia Laterza, Georg Busslinger, Hannah Stuart, Matteo Pagliari, Alessio Bortolami, Eva Mazzetto, Anna Manfredi, Chiara Colantuono, Lucio Di Filippo, Alessandro Filippo Pellegata, Valentina Panzarin, Nikhil Thapar, Vivian Sze Wing Li, Simon Eaton, Davide Cacchiarelli, Hans Clevers, Nicola Elvassore, Paolo De Coppi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Several clinical reports have described gastrointestinal symptoms for COVID-19, though whether the virus can replicate within the stomach remains unclear. Here the authors generate gastric organoids from human biopsies and show that the virus can eff
Externí odkaz:
https://doaj.org/article/16f8748d432646d085ed25fa4b80e5ce
Autor:
Onelia Gagliano, Camilla Luni, Yan Li, Silvia Angiolillo, Wei Qin, Francesco Panariello, Davide Cacchiarelli, Joseph S. Takahashi, Nicola Elvassore
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Chronic desynchronization between physiological and behavioral rhythms has been linked to the onset of metabolic diseases. Here the authors control the cyclic metabolic signals in a microfluidic device to study the effects of the timing, period and f
Externí odkaz:
https://doaj.org/article/2b6676ae7ada421c998d8e17c99a0e1e
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
In the last two decades lab-on-chip models, specifically heart-on-chip, have been developed as promising technologies for recapitulating physiological environments suitable for studies of drug and environmental effects on either human physiological o
Externí odkaz:
https://doaj.org/article/a6aa4a25182545b2a21d24cf7b0fad59
Autor:
Yang Yang, Cecilia Laterza, Hannah T. Stuart, Federica Michielin, Onelia Gagliano, Anna Urciuolo, Nicola Elvassore
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
The human developmental processes during the early post-implantation stage instruct the specification and organization of the lineage progenitors into a body plan. These processes, which include patterning, cell sorting, and establishment of the thre
Externí odkaz:
https://doaj.org/article/c64b3654a93a47d58fbfc7fe788c5d71
Autor:
Paolo Raffa, Valentina Scattolini, Mattia Francesco Maria Gerli, Silvia Perin, Meihua Cui, Paolo De Coppi, Nicola Elvassore, Paola Caccin, Camilla Luni, Anna Urciuolo
Publikováno v:
Stem Cells Translational Medicine, Vol 9, Iss 10, Pp 1233-1243 (2020)
Abstract Skeletal muscle decellularization allows the generation of natural scaffolds that retain the extracellular matrix (ECM) mechanical integrity, biological activity, and three‐dimensional (3D) architecture of the native tissue. Recent reports
Externí odkaz:
https://doaj.org/article/2958a840477c4d71a2a6a195d6d1d41a
Autor:
Giovanni Giuseppe Giobbe, Claire Crowley, Camilla Luni, Sara Campinoti, Moustafa Khedr, Kai Kretzschmar, Martina Maria De Santis, Elisa Zambaiti, Federica Michielin, Laween Meran, Qianjiang Hu, Gijs van Son, Luca Urbani, Anna Manfredi, Monica Giomo, Simon Eaton, Davide Cacchiarelli, Vivian S. W. Li, Hans Clevers, Paola Bonfanti, Nicola Elvassore, Paolo De Coppi
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Organoid cultures have been developed from multiple tissues, opening new possibilities for regenerative medicine. Here the authors demonstrate the derivation of GMP-compliant hydrogels from decellularized porcine small intestine which support formati
Externí odkaz:
https://doaj.org/article/a28b06f5539f456b97162079de3a5a5a