Therapy-related leukaemias with balanced translocations can arise from pre-existing clonal haematopoiesis

Autor: Nigel H. Russell, David Grimwade, Michael Dennis, Richard Dillon, Nicola Foot, Sandrine Jayne, Nicola E. Potter, Kavita Raj, Mikel Valganon, Matthew J. Ahearne, Lynn Quek, Sudhir Tauro, Jelena V. Jovanovic, Ellen Solomon, Martin J. S. Dyer

Publikováno v: Leukemia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0d245a9cb46d0dd22d01cd809a69082
https://doi.org/10.1038/s41375-021-01150-3

Venetoclax induces rapid elimination of NPM1 mutant measurable residual disease in combination with low‐intensity chemotherapy in acute myeloid leukaemia

Autor: Nicola E. Potter, Manohursingh Runglall, Adam Ivey, Anthony P. Schwarer, Kavita Raj, Phillip C. Nguyen, Nigel H. Russell, Chun Yew Fong, Annie‐Louise Latif, Andrew H. Wei, Tse-Chieh Teh, Andrew Grigg, Nicholas James Cummings, Ing Soo Tiong, Richard Dillon, David Taussig

Publikováno v: British Journal of Haematology

Summary Based on promising results in older adults with acute myeloid leukaemia (AML), we treated patients with NPM1 mut measurable residual disease (MRD) using off‐label venetoclax in combination with low‐dose cytarabine or azacitidine. Twelve c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::677b939db6f3dc479a1f8bc86d097fdb
https://doi.org/10.1111/bjh.16722

The Natural History of NPM1MUT Measurable Residual Disease (MRD) Positivity after Completion of Chemotherapy in Acute Myeloid Leukemia (AML)

Autor: Nisha Thiagarajah, Richard Dillon, Nigel H. Russell, Amanda F. Gilkes, Ashish Bajel, Ing Soo Tiong, Andrew H. Wei, Claire Hemmaway, Abin Thomas, Nicola E. Potter, Matthew Smith, James Anton Kuzich, Chung H. Kok, Adam Ivey

Publikováno v: Blood. 136:25-27

Introduction Molecular MRD assays targeting NPM1 mutant (mut) transcripts have an established role for monitoring treatment efficacy in patients with NPM1mut AML. Approximately 25% of NPM1mut patients show persistent MRD level in the bone marrow (BM)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bfdce1d2846f0299fd9ee3362b121572
https://doi.org/10.1182/blood-2020-140296

Molecular MRD status and outcome after transplantation in NPM1 mutated AML

Autor: Jelena V. Jovanovic, Michael Dennis, Manohursingh Runglall, Nicola E. Potter, Anju Kanda, Pramila Krishnamurthy, Igor Novitzky-Basso, Anjum Bashir Khan, Emmanouil Nikolousis, Alan Kenneth Burnett, Robert Kerrin Hills, Samah Alimam, David Grimwade, Ulrik Malthe Overgaard, Charles Craddock, Rosemary E. Gale, Asim Khwaja, Kate Hill, Richard Dillon, Nicola Foot, Adam Ivey, Rahuman Salim, Priyanka Mehta, Damian Finnegan, Erin Hurst, Amanda F. Gilkes, Sylvie D. Freeman, Matthew Lee Smith, David Taussig, Steven Knapper, Nigel H. Russell, Jamie Cavenagh, Mikel Valganon, Ruth Spearing, Hans Beier Ommen, Robert Danby, Kavita Raj, Harpreet Kaur, Peter R. E. Johnson

Publikováno v: Dillon, R, Hills, R K, Freeman, S D, Potter, N, Jovanovic, J, Ivey, A, Kanda, A, Runglall, M, Foot, N, Valganon, M, Khwaja, A, Cavenagh, J, Smith, M L, Ommen, H B, Overgaard, U, Dennis, M, Knapper, S, Kaur, H, Taussig, D C, Mehta, P, Raj, K, Novitzky-Basso, I, Nikolousis, E, Danby, R D, Krishnamurthy, P, Hill, K, Finnegan, D, Alimam, S, Hurst, E, Johnson, P, Khan, A B, Salim, R, Craddock, C F, Spearing, R L, Gilkes, A F, Gale, R E, Burnett, A K, Russell, N H & Grimwade, D 2020, ' Molecular MRD status and outcome after transplantation in NPM1 mutated AML ', Blood, vol. 135, no. 9, pp. 680-688 . https://doi.org/10.1182/blood.2019002959
Dillon, R, Hills, R, Freeman, S, Potter, N, Jovanovic, J, Ivey, A, Kanda, A S, Runglall, M, Foot, N, Valganon, M, Khwaja, A, Cavenagh, J, Smith, M, Ommen, H B, Overgaard, U M, Dennis, M, Knapper, S, Kaur, H, Taussig, D, Mehta, P, Raj, K, Novitzky-Basso, I, Nikolousis, E, Danby, R, Krishnamurthy, P, Hill, K, Finnegan, D, Alimam, S, Hurst, E, Johnson, P, Khan, A, Salim, R, Craddock, C, Spearing, R, Gilkes, A, Gale, R, Burnett, A, Russell, N H & Grimwade, D 2020, ' Molecular MRD status and outcome after transplantation in NPM1-mutated AML ', Blood, vol. 135, no. 9, pp. 680-688 . https://doi.org/10.1182/blood.2019002959

Relapse remains the most common cause of treatment failure for patients with acute myeloid leukemia (AML) who undergo allogeneic stem cell transplantation (alloSCT), and carries a grave prognosis. Multiple studies have identified the presence of meas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b21c643cbf633633d68fcbce8813cce
https://kclpure.kcl.ac.uk/en/publications/16321efb-66e2-4258-8991-eac3a8316f55

Clonal origins of ETV6-RUNX1+ acute lymphoblastic leukemia: studies in monozygotic twins

Autor: Marcela B. Mansur, Luca Ermini, Donát Alpár, Lyndal Kearney, Tomasz Szczepański, Ian Titley, D. Wren, Anthony M. Ford, F W van Delft, Mel Greaves, David Gonzalez, Nicola E. Potter, Caroline M. Bateman

Publikováno v: Leukemia. 29:839-846

Studies on twins with concordant acute lymphoblastic leukemia (ALL) have revealed that ETV6-RUNX1 gene fusion is a common, prenatal genetic event with other driver aberrations occurring subclonally and probably postnatally. The fetal cell type that i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ed8fab6a87cb84e405e51d4141daabc
https://doi.org/10.1038/leu.2014.322