Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Nicola Currey"'
Autor:
Nicola Currey, Zeenat Jahan, C. Elizabeth Caldon, Phuong N. Tran, Fahad Benthani, Penelope De Lacavalerie, Daniel L. Roden, Brian S. Gloss, Claudia Campos, Elaine G. Bean, Amanda Bullman, Saskia Reibe-Pal, Marcel E. Dinger, Mark A. Febbraio, Stephen J. Clarke, Jane E. Dahlstrom, Maija R.J. Kohonen-Corish
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 4, Pp 819-839 (2019)
Background & Aims: The early events by which inflammation promotes cancer are still not fully defined. The MCC gene is silenced by promoter methylation in colitis-associated and sporadic colon tumors, but its functional significance in precancerous l
Externí odkaz:
https://doaj.org/article/3f5a2d0c39a64c9b94fae8baddfca8d1
Autor:
Nicola Currey, Joseph J. Daniel, Dessislava N. Mladenova, Jane E. Dahlstrom, Maija R. J. Kohonen-Corish
Publikováno v:
Canadian Journal of Gastroenterology and Hepatology, Vol 2018 (2018)
Microsatellite instability (MSI) is caused by DNA mismatch repair deficiency and is an important prognostic and predictive biomarker in colorectal cancer but relatively few studies have exploited mouse models in the study of its clinical utility. Fur
Externí odkaz:
https://doaj.org/article/c9484e168dbd488989a2bdc4d5587766
Autor:
Dessislava N. Mladenova, Jane E. Dahlstrom, Phuong N. Tran, Fahad Benthani, Elaine G. Bean, Irvin Ng, Laurent Pangon, Nicola Currey, Maija R. J. Kohonen-Corish
Publikováno v:
Disease Models & Mechanisms, Vol 8, Iss 9, Pp 1093-1103 (2015)
Hypoxia-inducible factor 1α (HIF1α) is a transcription factor that regulates the adaptation of cells to hypoxic microenvironments, for example inside solid tumours. Stabilisation of HIF1α can also occur in normoxic conditions in inflamed tissue or
Externí odkaz:
https://doaj.org/article/c4eabf5f865941bdb4e7569db2f3fceb
Autor:
Fahad Benthani, Phuong N. Tran, Nicola Currey, Irvin Ng, Marc Giry-Laterriere, Louise Carey, Maija R. J. Kohonen-Corish, Laurent Pangon
Publikováno v:
International Journal of Molecular Sciences, Vol 16, Iss 5, Pp 11522-11530 (2015)
Mutations of the SHANK3 gene have been associated with autism spectrum disorder. Individuals harboring different SHANK3 mutations display considerable heterogeneity in their cognitive impairment, likely due to the high SHANK3 transcriptional diversit
Externí odkaz:
https://doaj.org/article/1ad5d025264c4fda885a35f795aaf6ea
Autor:
Mark A. Jenkins, Maija R.J. Kohonen-Corish, Nicola Currey, Sabine Meessen, Zeenat Jahan, Hannah W. Parker, Daniel D. Buchanan, Eva Segelov, John L. Hopper, Jane E. Dahlstrom
Publikováno v:
Cancers
Volume 13
Issue 14
Cancers, Vol 13, Iss 3529, p 3529 (2021)
Volume 13
Issue 14
Cancers, Vol 13, Iss 3529, p 3529 (2021)
Simple Summary A type of DNA mismatch repair defect known as “elevated microsatellite alterations at selected tetranucleotide repeats” (EMAST) is found across many different cancers. Tetranucleotide microsatellite instability, which is caused by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c5d06c4f2c61d1dbb1cee8c4893e58d
https://hdl.handle.net/10453/154593
https://hdl.handle.net/10453/154593
Autor:
Zeenat Jahan, Fahad A. Benthani, Nicola Currey, Hannah W. Parker, Jane E. Dahlstrom, C. Elizabeth Caldon, Maija R. J. Kohonen-Corish
Publikováno v:
Cancers; Volume 14; Issue 12; Pages: 2859
Chemotherapy is a mainstay of colorectal cancer treatment, and often involves a combination drug regime. CpG island methylator phenotype (CIMP)-positive tumors are potentially more responsive to the topoisomerase-inhibitor irinotecan. The mechanistic
Autor:
Saskia Reibe-Pal, Mark A. Febbraio, Amanda Bullman, Brian S. Gloss, Elaine G. Bean, C. Elizabeth Caldon, Stephen Clarke, Marcel E. Dinger, Nicola Currey, Daniel L. Roden, Maija R.J. Kohonen-Corish, Phuong N. Tran, Penelope De Lacavalerie, Fahad Benthani, Jane E. Dahlstrom, Claudia Guimarães Camargo Campos, Zeenat Jahan
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 4, Pp 819-839 (2019)
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 4, Pp 819-839 (2019)
Background & Aims The early events by which inflammation promotes cancer are still not fully defined. The MCC gene is silenced by promoter methylation in colitis-associated and sporadic colon tumors, but its functional significance in precancerous le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c468af758b15860c11906bdd37df6fef
Autor:
Dessislava Mladenova, Jane E. Dahlstrom, Joseph J. Daniel, Nicola Currey, Maija R.J. Kohonen-Corish
Publikováno v:
Canadian Journal of Gastroenterology and Hepatology, Vol 2018 (2018)
Canadian Journal of Gastroenterology & Hepatology
Canadian Journal of Gastroenterology & Hepatology
Microsatellite instability (MSI) is caused by DNA mismatch repair deficiency and is an important prognostic and predictive biomarker in colorectal cancer but relatively few studies have exploited mouse models in the study of its clinical utility. Fur
Autor:
Christa Van Kralingen, Laurent Pangon, Patrick Lécine, Maija R.J. Kohonen-Corish, Sam Al-Sohaily, Dessislava Mladenova, Lauren Watkins, Nicola Currey, Jean-Paul Borg
Publikováno v:
International Journal of Cancer. 136:55-64
The mutated in colorectal cancer (MCC) is a multifunctional gene showing loss of expression in colorectal and liver cancers. MCC mutations can drive colon carcinogenesis in the mouse and in vitro experiments suggest that loss of MCC function promotes
Autor:
Amr H. Allam, Maija R.J. Kohonen-Corish, Fahad Benthani, Paul Timpson, Nicola Currey, Sam Al-Sohaily, T. Phuong, Janindra Warusavitarne, Morghan C. Lucas, David Herrmann
Publikováno v:
ESMO Open. 3:A86-A87
Introduction The ‘Mutated in colorectal cancer’ (MCC) gene was originally discovered due to its linkage with the APC gene. MCC is silenced through gene promoter methylation in colorectal cancer (CRC) but its significance has been poorly understoo