Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Nicola Broadbent"'
Autor:
Simon T. Barry, Stephen R. Wedge, Masabumi Shibuya, Juliane M. Jürgensmeier, Donald J. Ogilvie, Laurent Hennequin, Charles L. Farnsworth, Jeffrey C. Silva, Claire Barnes, Sian Taylor, Graham Sproat, Nicola Broadbent, Philippa Dudley, Jane Kendrew, Anna Wainwright, Sue Ashton, Neil H. James, Zena Wilson, Kirsty Ratcliffe, Sandra R. Brave
Supplementary Figure Legend from Assessing the Activity of Cediranib, a VEGFR-2/3 Tyrosine Kinase Inhibitor, against VEGFR-1 and Members of the Structurally Related PDGFR Family
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::908f9c406205b7374b4c5f4dca4484fd
https://doi.org/10.1158/1535-7163.22496461
https://doi.org/10.1158/1535-7163.22496461
Autor:
Simon T. Barry, Stephen R. Wedge, Masabumi Shibuya, Juliane M. Jürgensmeier, Donald J. Ogilvie, Laurent Hennequin, Charles L. Farnsworth, Jeffrey C. Silva, Claire Barnes, Sian Taylor, Graham Sproat, Nicola Broadbent, Philippa Dudley, Jane Kendrew, Anna Wainwright, Sue Ashton, Neil H. James, Zena Wilson, Kirsty Ratcliffe, Sandra R. Brave
Supplementary Tables 1-3 from Assessing the Activity of Cediranib, a VEGFR-2/3 Tyrosine Kinase Inhibitor, against VEGFR-1 and Members of the Structurally Related PDGFR Family
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b81f7c3e475189f7807aec38b527252
https://doi.org/10.1158/1535-7163.22496458.v1
https://doi.org/10.1158/1535-7163.22496458.v1
Autor:
Simon T. Barry, Stephen R. Wedge, Masabumi Shibuya, Juliane M. Jürgensmeier, Donald J. Ogilvie, Laurent Hennequin, Charles L. Farnsworth, Jeffrey C. Silva, Claire Barnes, Sian Taylor, Graham Sproat, Nicola Broadbent, Philippa Dudley, Jane Kendrew, Anna Wainwright, Sue Ashton, Neil H. James, Zena Wilson, Kirsty Ratcliffe, Sandra R. Brave
Supplementary Figure 1 from Assessing the Activity of Cediranib, a VEGFR-2/3 Tyrosine Kinase Inhibitor, against VEGFR-1 and Members of the Structurally Related PDGFR Family
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e3cd5c5600a7c3ff0d61470189a4156
https://doi.org/10.1158/1535-7163.22496464
https://doi.org/10.1158/1535-7163.22496464
Autor:
Simon T. Barry, Stephen R. Wedge, Masabumi Shibuya, Juliane M. Jürgensmeier, Donald J. Ogilvie, Laurent Hennequin, Charles L. Farnsworth, Jeffrey C. Silva, Claire Barnes, Sian Taylor, Graham Sproat, Nicola Broadbent, Philippa Dudley, Jane Kendrew, Anna Wainwright, Sue Ashton, Neil H. James, Zena Wilson, Kirsty Ratcliffe, Sandra R. Brave
Cediranib is a potent inhibitor of the VEGF receptor (VEGFR)-2 and VEGFR-3 tyrosine kinases. This study assessed the activity of cediranib against the VEGFR-1 tyrosine kinase and the platelet-derived growth factor receptor (PDGFR)-associated kinases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c66c6430c693a5c3aeeab117ab20e0f
https://doi.org/10.1158/1535-7163.c.6535279
https://doi.org/10.1158/1535-7163.c.6535279
Autor:
A. Nigel Brooks, Stephen R. Wedge, Susan E. Critchlow, Craig N. Robson, Simon T. Barry, Chris Womack, Luke Gaughan, Alfred Rabow, Robert H. Bradbury, Rhys D.O. Jones, Joanne Wilson, Marie Cumberbatch, Vivien N. Jacobs, Fadhel S. Shaheen, Elizabeth Mouchet, Dawn Trueman, Natalie C. Stratton, Nicola Broadbent, Sandra R. Brave, Tom P.J. Dunkley, Graeme E. Walker, David M. Robinson, Andrew G. Thomason, Sarah J. Ross, Sarah A. Loddick
PDF - 56KB, Supplementary methods detailing Relative peptide quantification by selected reaction monitoring (SRM)using mass spectrometry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54d12f691841ae5003bde43d483fc498
https://doi.org/10.1158/1535-7163.22500958
https://doi.org/10.1158/1535-7163.22500958
Autor:
A. Nigel Brooks, Stephen R. Wedge, Susan E. Critchlow, Craig N. Robson, Simon T. Barry, Chris Womack, Luke Gaughan, Alfred Rabow, Robert H. Bradbury, Rhys D.O. Jones, Joanne Wilson, Marie Cumberbatch, Vivien N. Jacobs, Fadhel S. Shaheen, Elizabeth Mouchet, Dawn Trueman, Natalie C. Stratton, Nicola Broadbent, Sandra R. Brave, Tom P.J. Dunkley, Graeme E. Walker, David M. Robinson, Andrew G. Thomason, Sarah J. Ross, Sarah A. Loddick
PDF - 464KB, Supplementary Figure 1: Inhibition of AR transcripts with AZD3514 treated LNCaPs in steroid free media and the timecourse of AZD3514 effects in the presence and absence of DHT. Supplementary Figure 2: Effect of AZD3514 on growth of AR ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5d194c3a51c866f292b69afd928b73e
https://doi.org/10.1158/1535-7163.22500961
https://doi.org/10.1158/1535-7163.22500961
Autor:
A. Nigel Brooks, Stephen R. Wedge, Susan E. Critchlow, Craig N. Robson, Simon T. Barry, Chris Womack, Luke Gaughan, Alfred Rabow, Robert H. Bradbury, Rhys D.O. Jones, Joanne Wilson, Marie Cumberbatch, Vivien N. Jacobs, Fadhel S. Shaheen, Elizabeth Mouchet, Dawn Trueman, Natalie C. Stratton, Nicola Broadbent, Sandra R. Brave, Tom P.J. Dunkley, Graeme E. Walker, David M. Robinson, Andrew G. Thomason, Sarah J. Ross, Sarah A. Loddick
PDF - 71KB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36cd40a1e742de8a4011274fdf37bb1e
https://doi.org/10.1158/1535-7163.22500964.v1
https://doi.org/10.1158/1535-7163.22500964.v1
Autor:
A. Nigel Brooks, Stephen R. Wedge, Susan E. Critchlow, Craig N. Robson, Simon T. Barry, Chris Womack, Luke Gaughan, Alfred Rabow, Robert H. Bradbury, Rhys D.O. Jones, Joanne Wilson, Marie Cumberbatch, Vivien N. Jacobs, Fadhel S. Shaheen, Elizabeth Mouchet, Dawn Trueman, Natalie C. Stratton, Nicola Broadbent, Sandra R. Brave, Tom P.J. Dunkley, Graeme E. Walker, David M. Robinson, Andrew G. Thomason, Sarah J. Ross, Sarah A. Loddick
PDF - 329KB, Supplementary Table 1: TSQ Vantage mass spectrometry instrument settings. Supplementary Table 2: 4000 QTRAP mass spectrometry instrument settings. Supplementary Table 3: The half-life of AR for the first 6 hours following treatment calcu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b48ad0925bc03fcf57e4609a27abf58
https://doi.org/10.1158/1535-7163.22500955
https://doi.org/10.1158/1535-7163.22500955
Autor:
Nicola Broadbent, Vanessa Selak
Publikováno v:
International journal of epidemiology. 51(3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::327215ba1e9afecea7c3e62cbe0cfbb0
https://pubmed.ncbi.nlm.nih.gov/33655302
https://pubmed.ncbi.nlm.nih.gov/33655302
Autor:
A. Nigel Brooks, Vivien Jacobs, Dawn Trueman, Luke Gaughan, Marie Cumberbatch, Sarah Ross, Fadhel Shaheen, Tom Dunkley, Joanne Wilson, Craig N. Robson, Chris Womack, Andrew G. Thomason, Rhys D.O. Jones, David Robinson, Susan E. Critchlow, Alfred A. Rabow, Graeme Walker, Natalie Stratton, Stephen R. Wedge, Elizabeth Mouchet, Robert Hugh Bradbury, Simon T. Barry, Sarah A. Loddick, Nicola Broadbent, Sandra R. Brave
Publikováno v:
Molecular Cancer Therapeutics. 12:1715-1727
Continued androgen receptor (AR) expression and signaling is a key driver in castration-resistant prostate cancer (CRPC) after classical androgen ablation therapies have failed, and therefore remains a target for the treatment of progressive disease.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9ddfdaa56bf6708984f486738a02cc8
https://doi.org/10.1158/1535-7163.mct-12-1174
https://doi.org/10.1158/1535-7163.mct-12-1174