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Autor:
Iain R. Challis, Lindsey Low, Peter F. Leadlay, Rolf Müller, Barrie Wilkinson, Steven G. Kendrew, Jose Garcia-Bernardo, Hans-Jürgen Hecht, Hrvoje Petković, Axel Sandmann, Barbara Silakowski, Enej Kuščer, Nicola Beeston
Publikováno v:
Org. Biomol. Chem.. 6:500-506
The production of epothilone mixtures is a direct consequence of the substrate tolerance of the module 3 acyltransferase (AT) domain of the epothilone polyketide synthase (PKS) which utilises both malonyl- and methylmalonyl-CoA extender units. Partic