Zobrazeno 1 - 10
of 208
pro vyhledávání: '"Nicola Antonio Colabufo"'
Autor:
Laura Braconi, Chiara Riganti, Astrid Parenti, Marta Cecchi, Alessio Nocentini, Gianluca Bartolucci, Marta Menicatti, Marialessandra Contino, Nicola Antonio Colabufo, Dina Manetti, Maria Novella Romanelli, Claudiu T. Supuran, Elisabetta Teodori
Publikováno v:
Molecules, Vol 29, Iss 14, p 3290 (2024)
A new series of piperazine derivatives were synthesized and studied with the aim of obtaining dual inhibitors of P-glycoprotein (P-gp) and carbonic anhydrase XII (hCA XII) to synergistically overcome the P-gp-mediated multidrug resistance (MDR) in ca
Externí odkaz:
https://doaj.org/article/7f0fc90ebe6b4e25b07123ec416bb9e1
Autor:
Francesca Serena Abatematteo, Pietro Delre, Ivan Mercurio, Veronica V. Rezelj, Dritan Siliqi, Stephanie Beaucourt, Gianluca Lattanzi, Nicola Antonio Colabufo, Marcello Leopoldo, Michele Saviano, Marco Vignuzzi, Giuseppe Felice Mangiatordi, Carmen Abate
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract The development of effective drugs to treat coronavirus infections remains a significant challenge for the scientific community. Recent evidence reports on the sigma-1 receptor (S1R) as a key druggable host protein in the SARS-CoV-1 and SARS
Externí odkaz:
https://doaj.org/article/165bc5a82cb64f1eb1159816b6b1c11a
Autor:
Diellza Bajrami, Syed Imdadul Hossain, Alexia Barbarossa, Maria Chiara Sportelli, Rosaria Anna Picca, Luigi Gentile, Francesco Mastrolonardo, Antonio Rosato, Alessia Carocci, Nicola Antonio Colabufo, Boris Mizaikoff, Nicola Cioffi
Publikováno v:
Heliyon, Vol 10, Iss 3, Pp e25260- (2024)
This study explores how a simple argentometric titration-like approach could be evolved into a versatile, scalable, fast, and robust strategy for the production of AgCl/quaternary ammonium compounds (QACs) colloidal nanoantimicrobials (NAMs). These s
Externí odkaz:
https://doaj.org/article/b4d0818322a24ae68f7a72ba244243f8
Autor:
Stefania De Santis, Pasquale Crupi, Laura Piacente, Anna Mestice, Nicola Antonio Colabufo, Loredana Amodio, Paola Pontrelli, Loreto Gesualdo, Antonio Moschetta, Maria Lisa Clodoveo, Maria Felicia Faienza, Filomena Corbo
Publikováno v:
Frontiers in Nutrition, Vol 9 (2022)
Obesity represents an important public health challenge of the twenty first century reaching epidemic proportions worldwide; this is especially true for the pediatric population. In this context, bioactive compounds from foods are crucial to countera
Externí odkaz:
https://doaj.org/article/0193a5cbcf2a4ce5b05e74db68509d4a
Autor:
Gianvito Caggiano, Loredana Amodio, Alessandra Stasi, Nicola Antonio Colabufo, Santina Colangiulo, Francesco Pesce, Loreto Gesualdo
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 6, p 5142 (2023)
In the past years, indoxyl sulfate has been strongly implicated in kidney disease progression and contributed to cardiovascular morbidity. Moreover, as a result of its elevated albumin affinity rate, indoxyl sulfate is not adequately cleared by extra
Externí odkaz:
https://doaj.org/article/3a6b844a1e324579a8835fbbdee62d8b
Autor:
Laura Braconi, Gianluca Bartolucci, Marialessandra Contino, Niccolò Chiaramonte, Roberta Giampietro, Dina Manetti, Maria Grazia Perrone, Maria Novella Romanelli, Nicola Antonio Colabufo, Chiara Riganti, Silvia Dei, Elisabetta Teodori
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 974-992 (2020)
Aiming to deepen the structure–activity relationships of the two P-glycoprotein (P-gp) modulators elacridar and tariquidar, a new series of amide and ester derivatives carrying a 6,7-dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline scaffold lin
Externí odkaz:
https://doaj.org/article/80d6ac8beb384353b1f30d4afc238f16
Autor:
Carmen Abate, Mauro Niso, Francesca Serena Abatematteo, Marialessandra Contino, Nicola Antonio Colabufo, Francesco Berardi
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
These unprecedented times have forced the scientific community to gather to face the COVID-19 pandemic. Efforts in diverse directions have been made. A multi-university team has focused on the identification of the host (human) proteins interacting w
Externí odkaz:
https://doaj.org/article/b9551cfc337641e990698ea4339ee08a
Autor:
Andreas Gisel, Mirna Valvano, Imane Ghafir El Idrissi, Patrizia Nardulli, Amalia Azzariti, Antonio Carrieri, Marialessandra Contino, Nicola Antonio Colabufo
Publikováno v:
Molecules, Vol 19, Iss 5, Pp 5611-5623 (2014)
The goal of the present paper is to establish and validate the link between cancer diagnosis and therapy by microRNAs detection. The induction in vitro of some specific microRNAs after treatment with MDR ligands has been outlined. Starting from the r
Externí odkaz:
https://doaj.org/article/f8ff3e4b859448908e0ddd58680bb110
Autor:
LAURA eZINZI, Marialessandra eContino, Mariangela eCantore, Elena eCapparelli, Marcello eLeopoldo, Nicola Antonio Colabufo
Publikováno v:
Frontiers in Pharmacology, Vol 5 (2014)
CSCs are responsible for the high rate of recurrence and chemoresistance of different type of cancers. The current antineoplastic agents, able to inhibit bulk replicating cancer cells and radiation treatment, were found inefficacious towards CSCs sin
Externí odkaz:
https://doaj.org/article/8b1c2965e2194c85b78a7d94636b74ea
Autor:
Laura eZinzi, Elena eCapparelli, Mariangela eCantore, Marialessandra eContino, Marcello eLeopoldo, Nicola Antonio Colabufo
Publikováno v:
Frontiers in Oncology, Vol 4 (2014)
MDR is a complex phenomenon principally due to the overexpression of some transmembrane proteins belonging to the ATP Binding Cassette (ABC) transporter family. Among these transporters, P-Glycoprotein (P-gp), is the mostly involved in MDR and its ov
Externí odkaz:
https://doaj.org/article/7856537f9fd849ccb0c7d8586b519755