Zobrazeno 1 - 10
of 259
pro vyhledávání: '"Nicola A. Smith"'
Autor:
Estee P. M. Lau, Matthew Ing, Sona Vekaria, Ai Ling Tan, Chloe Charlesworth, Edward Fysh, Ranjan Shrestha, Elaine L. C. Yap, Nicola A. Smith, Benjamin C. H. Kwan, Tajalli Saghaie, Bapti Roy, John Goddard, Sanjeevan Muruganandan, Arash Badiei, Phan Nguyen, Mohamed Faisal Abdul Hamid, Vineeth George, Deirdre Fitzgerald, Nick Maskell, David Feller-Kopman, Kevin Murray, Aron Chakera, Y C Gary Lee
Publikováno v:
Trials, Vol 25, Iss 1, Pp 1-8 (2024)
Abstract Background Malignant pleural effusion (MPE) is a debilitating condition as it commonly causes disabling breathlessness and impairs quality of life (QoL). Indwelling pleural catheter (IPC) offers an effective alternative for the management of
Externí odkaz:
https://doaj.org/article/49c7885fe76f42b088f3cbc92eb741de
Autor:
Deirdre B. Fitzgerald, Calvin Sidhu, Charley Budgeon, Ai Ling Tan, Catherine A. Read, Benjamin C. H. Kwan, Nicola Ann Smith, Edward T. Fysh, Sanjeevan Muruganandan, Tajalli Saghaie, Ranjan Shrestha, Arash Badiei, Phan Nguyen, Andrew Burke, John Goddard, Morgan Windsor, Julie McDonald, Gavin Wright, Kasia Czarnecka, Parthipan Sivakumar, Kazuhiro Yasufuku, David J. Feller-Kopman, Nick A. Maskell, Kevin Murray, Y. C. Gary Lee
Publikováno v:
Trials, Vol 23, Iss 1, Pp 1-9 (2022)
Abstract Introduction Malignant pleural effusions (MPEs) are common. MPE causes significant breathlessness and impairs quality of life. Indwelling pleural catheters (IPC) allow ambulatory drainage and reduce hospital days and re-intervention rates wh
Externí odkaz:
https://doaj.org/article/d197bf0e95e24aeeb65efbdf08e3c8b2
Autor:
Neha Shah, Ian F. Walker, Yannish Naik, Selina Rajan, Kate O’Hagan, Michelle Black, Christopher Cartwright, Taavi Tillmann, Nicola Pearce-Smith, Jude Stansfield
Publikováno v:
BMC Public Health, Vol 21, Iss 1, Pp 1-14 (2021)
Abstract Background Social circumstances in which people live and work impact the population’s mental health. We aimed to synthesise evidence identifying effective interventions and policies that influence the social determinants of mental health a
Externí odkaz:
https://doaj.org/article/746dd54dad0f43b1b7f26f5f7232901c
Publikováno v:
Systematic Reviews, Vol 9, Iss 1, Pp 1-6 (2020)
Abstract Background Gambling and problem gambling are increasingly being viewed as a public health issue. European surveys have reported a high prevalence of gambling, and according to the Gambling Commission, in 2018, almost half of the general popu
Externí odkaz:
https://doaj.org/article/803cc88bf32f443281a8769acce469d1
Publikováno v:
Systematic Reviews, Vol 9, Iss 1, Pp 1-6 (2020)
Abstract Background According to the Gambling Commission, in 2018, almost half of the general population aged 16 and over had participated in gambling in the 4 weeks before being surveyed. Such surveys suggest that the proportion of people who are cl
Externí odkaz:
https://doaj.org/article/347069e2f29941cfa34341b8f9184ce5
Publikováno v:
Acta Orthopaedica, Vol 91, Iss 3, Pp 313-318 (2020)
Background and purpose — Essential for safe and timely hospital discharge, inpatient functional recovery following lower limb arthroplasty is also variable. A previous systematic review reported moderate and conflicting levels of evidence regarding
Externí odkaz:
https://doaj.org/article/3ede93a9558d475f9a66478252d5df9e
Autor:
Adam P. Curnock, Giovanna Bossi, Jyothi Kumaran, Lindsay J. Bawden, Rita Figueiredo, Rajeevkumar Tawar, Katherine Wiseman, Emma Henderson, Sec Julie Hoong, Veronica Gonzalez, Hemza Ghadbane, David E.O. Knight, Ronan O’Dwyer, David X. Overton, Christina M. Lucato, Nicola M.G. Smith, Carlos R. Reis, Keith Page, Lorraine M. Whaley, Michelle L. McCully, Stephen Hearty, Tara M. Mahon, Peter Weber
Publikováno v:
JCI Insight, Vol 6, Iss 20 (2021)
The PD-1/PD-L1 pathway is a key immune checkpoint that regulates T cell activation. There is strong rationale to develop PD-1 agonists as therapeutics against autoimmunity, but progress in this area has been limited. Here, we generated T cell recepto
Externí odkaz:
https://doaj.org/article/76d2b586086f49e3988424380f1b73ad
Autor:
Sarah W Davies, Hollie M Putnam, Tracy Ainsworth, Julia K Baum, Colleen B Bove, Sarah C Crosby, Isabelle M Côté, Anne Duplouy, Robinson W Fulweiler, Alyssa J Griffin, Torrance C Hanley, Tessa Hill, Adriana Humanes, Sangeeta Mangubhai, Anna Metaxas, Laura M Parker, Hanny E Rivera, Nyssa J Silbiger, Nicola S Smith, Ana K Spalding, Nikki Traylor-Knowles, Brooke L Weigel, Rachel M Wright, Amanda E Bates
Publikováno v:
PLoS Biology, Vol 19, Iss 6, p e3001282 (2021)
Success and impact metrics in science are based on a system that perpetuates sexist and racist "rewards" by prioritizing citations and impact factors. These metrics are flawed and biased against already marginalized groups and fail to accurately capt
Externí odkaz:
https://doaj.org/article/3453aa9943b84091af339c67762ac8af
Autor:
Margaret A. Mouat, Brendan P. Wilkins, Eileen Ding, Hemna Govindaraju, James L. J. Coleman, Robert M. Graham, Nigel Turner, Nicola J. Smith
Publikováno v:
Cells, Vol 11, Iss 11, p 1814 (2022)
Understanding the neurogenic causes of obesity may reveal novel drug targets to counter the obesity crisis and associated sequelae. Here, we investigate whether the deletion of GPR37L1, an astrocyte-specific orphan G protein-coupled receptor, affects
Externí odkaz:
https://doaj.org/article/d2ac150e46bc4892b1851a024e38dfe3
Autor:
Margaret A. Mouat, Kristy L. Jackson, James L. J. Coleman, Madeleine R. Paterson, Robert M. Graham, Geoffrey A. Head, Nicola J. Smith
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2021)
GPR37L1 is a family A orphan G protein-coupled receptor (GPCR) with a putative role in blood pressure regulation and cardioprotection. In mice, genetic ablation of Gpr37l1 causes sex-dependent effects; female mice lacking Gpr37l1 (GPR37L1−/−) hav
Externí odkaz:
https://doaj.org/article/9784a4b06c654138ba44b8698436d310