Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Nicola A. Philbrook"'
Gestational exposure to triphenyl phosphate induces epigenetic modifications in C57Bl /6 fetal liver
Publikováno v:
Birth Defects Research. 115:338-347
Triphenyl phosphate (TPHP) is a chemical flame retardant and plasticizer which is added to consumer and industrial products. The developmental origins of health and disease hypothesis postulate that in utero exposures can have later-in-life effects o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ce04dca753a512b00c6b5d3954e33da
https://doi.org/10.1002/bdr2.2121
https://doi.org/10.1002/bdr2.2121
Publikováno v:
Birth Defects Research. 110:483-494
Triphenyl phosphate (TPhP) is an organophosphorus flame retardant and plasticizer that has been added to numerous consumer products in recent years. TPhP is not overtly toxic, however recent studies have suggested that it may have metabolic disruptin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e3a4e1467388ae6db396315c69a4e96
https://doi.org/10.1002/bdr2.1185
https://doi.org/10.1002/bdr2.1185
Publikováno v:
Reproductive Toxicology. 74:32-39
The nuclear factor-kappa B (NF-κB) family of transcription factors regulate gene expression in response to diverse stimuli. We previously demonstrated that valproic acid (VPA) exposure in utero decreases total cellular protein expression of the NF-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78df3a0f11fccdd8d9d0bbbc23d7ec47
https://doi.org/10.1016/j.reprotox.2017.08.019
https://doi.org/10.1016/j.reprotox.2017.08.019
Autor:
Louise M. Winn, Nicola A. Philbrook
Publikováno v:
Journal of Applied Toxicology. 36:1015-1024
Benzene is an environmental pollutant known to cause leukemia in adults, and may be associated with childhood leukemia. While the mechanisms of benzene-mediated carcinogenicity have not been fully elucidated, increased reactive oxygen species (ROS) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6190f9ea68aa4482458860887a1d431b
https://doi.org/10.1002/jat.3251
https://doi.org/10.1002/jat.3251
Autor:
Louise M. Winn, Nicola A. Philbrook
Publikováno v:
Reproductive Toxicology. 43:30-37
The study objective was to determine if maternal administration of sulforaphane (SFN) induced Nrf2-controlled genes. In acute studies, when non-pregnant and pregnant mice were orally exposed to SFN (50 or 100 mg/kg) on gestational day (GD) 14 and eut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12061c4b2d8b1acdf3076a2d4f63115c
https://doi.org/10.1016/j.reprotox.2013.10.009
https://doi.org/10.1016/j.reprotox.2013.10.009
Publikováno v:
Toxicological Sciences. 126:569-577
In utero exposure to environmental carcinogens, including the ubiquitous pollutant benzene, may cause DNA damage in the fetus, leading to an increased risk for the development of childhood cancer. Benzene metabolite-induced DNA double-strand breaks (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b51b42297a484e38676db268100d0fe
https://doi.org/10.1093/toxsci/kfs001
https://doi.org/10.1093/toxsci/kfs001
Autor:
Virginia K. Walker, A. R. M. Nabiul Afrooz, Nicola A. Philbrook, Navid B. Saleh, Louise M. Winn
Publikováno v:
Reproductive Toxicology. 32:442-448
Despite numerous applications for functionalized carbon nanotubes (fCNTs) in consumer products, such as electronics, and food packaging, as well as their development as drug delivery vehicles, the consequence of their uptake by living systems has bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb7e99c3ec96b5d4a76b9812c3f378e1
https://doi.org/10.1016/j.reprotox.2011.09.002
https://doi.org/10.1016/j.reprotox.2011.09.002
Autor:
Nicola A, Philbrook, Louise M, Winn
Publikováno v:
Journal of applied toxicology : JAT. 36(8)
Benzene is an environmental pollutant known to cause leukemia in adults, and may be associated with childhood leukemia. While the mechanisms of benzene-mediated carcinogenicity have not been fully elucidated, increased reactive oxygen species (ROS) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7052734d568efc2e5e4b2e4f472a8be2
https://pubmed.ncbi.nlm.nih.gov/26456483
https://pubmed.ncbi.nlm.nih.gov/26456483
Autor:
Nicola A. Philbrook, Louise M. Winn
Publikováno v:
Toxicology and applied pharmacology. 289(1)
Exposure to the ubiquitous environmental pollutant benzene is positively correlated with leukemia in adults and may be associated with childhood leukemia following in utero exposure. While numerous studies implicate oxidative stress and DNA damage as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57be4dbd68c7503c900385515e2971c0
https://pubmed.ncbi.nlm.nih.gov/26341289
https://pubmed.ncbi.nlm.nih.gov/26341289
Autor:
Nicola A. Philbrook, Louise M. Winn
Publikováno v:
Oxidative Stress in Applied Basic Research and Clinical Practice ISBN: 9783319190952
Isolation of adult bone marrow and fetal liver cells from murine models is an important technique that can be a valuable tool to study mechanisms of hematotoxicity. Organic solvents are a class of industrial chemicals that can target the bone marrow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18d2d1945f442c6db534d2ff63c3d23d
https://doi.org/10.1007/978-3-319-19096-9_10
https://doi.org/10.1007/978-3-319-19096-9_10
