Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Nicola A. Burgess-Brown"'
Autor:
Huanyu Z. Li, Ashley C. W. Pike, Irina Lotsaris, Gamma Chi, Jesper S. Hansen, Sarah C. Lee, Karin E. J. Rödström, Simon R. Bushell, David Speedman, Adam Evans, Dong Wang, Didi He, Leela Shrestha, Chady Nasrallah, Nicola A. Burgess-Brown, Robert J. Vandenberg, Timothy R. Dafforn, Elisabeth P. Carpenter, David B. Sauer
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Proline is widely known as the only proteogenic amino acid with a secondary amine. In addition to its crucial role in protein structure, the secondary amino acid modulates neurotransmission and regulates the kinetics of signaling proteins. T
Externí odkaz:
https://doaj.org/article/32dcb0d22d77485888ff653efcd48c4e
Autor:
Gamma Chi, Qiansheng Liang, Akshay Sridhar, John B. Cowgill, Kasim Sader, Mazdak Radjainia, Pu Qian, Pablo Castro-Hartmann, Shayla Venkaya, Nanki Kaur Singh, Gavin McKinley, Alejandra Fernandez-Cid, Shubhashish M. M. Mukhopadhyay, Nicola A. Burgess-Brown, Lucie Delemotte, Manuel Covarrubias, Katharina L. Dürr
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Here, Chi et al. report cryo-EM structures of the human Kv3.1a channel, revealing a unique arrangement of the cytoplasmic T1 domain, which allows the interactions with the C-terminal axonal targeting motif and key components of the gating machinery.
Externí odkaz:
https://doaj.org/article/3b1f137234894981ba29f62e3c7d792a
Autor:
Rod Chalk, William E. P. Greenland, Tiago Moreira, Jesse Coker, Shubhashish M. M. Mukhopadhyay, Eleanor Williams, Charlotte Manning, Tina Bohstedt, Rama McCrorie, Alejandra Fernandez-Cid, Nicola A. Burgess-Brown
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-8 (2021)
Mapping multiple glycan species to the same peptide and location from shared retention time of glycopeptides with MS and HPLC, Chalk, Greenland et al. construct a detailed mass-retention time database for Spike protein glycopeptides. This allows any
Externí odkaz:
https://doaj.org/article/c526a34029cf4619809766a292866602
Autor:
Jesse A. Coker, Vittorio L. Katis, Michael Fairhead, Anja Schwenzer, Stine B. Clemmensen, Bent U. Frandsen, Willem A. de Jongh, Opher Gileadi, Nicola A. Burgess-Brown, Brian D. Marsden, Kim S. Midwood, Wyatt W. Yue
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
Recombinant protein expression in eukaryotic insect cells is a powerful approach for producing challenging targets. However, due to incompatibility with standard baculoviral platforms and existing low-throughput methodology, the use of the Drosophila
Externí odkaz:
https://doaj.org/article/b1a66327cf994b558e7f1cba4b4aa7bc
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Peptide-based cancer vaccines rely upon the strong activation of the adaptive immune response to elicit its effector function. They have shown to be highly specific and safe, but have yet to prove themselves as an efficacious treatment for cancer in
Externí odkaz:
https://doaj.org/article/667e9d992db54d0d8e949fcaf7e7a33c
Autor:
Simon R. Bushell, Ashley C. W. Pike, Maria E. Falzone, Nils J. G. Rorsman, Chau M. Ta, Robin A. Corey, Thomas D. Newport, John C. Christianson, Lara F. Scofano, Chitra A. Shintre, Annamaria Tessitore, Amy Chu, Qinrui Wang, Leela Shrestha, Shubhashish M. M. Mukhopadhyay, James D. Love, Nicola A. Burgess-Brown, Rebecca Sitsapesan, Phillip J. Stansfeld, Juha T. Huiskonen, Paolo Tammaro, Alessio Accardi, Elisabeth P. Carpenter
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
TMEM16K is a member of the TMEM16 family of integral membrane proteins that are either lipid scramblases or chloride channels. Here the authors combine cell biology, electrophysiology measurements, X-ray crystallography, cryo-EM and MD simulations to
Externí odkaz:
https://doaj.org/article/602dd2cc133c49529d8807b7b0d875ca
Autor:
Huanyu Z. Li, Ashley C.W. Pike, Gamma Chi, Jesper S. Hansen, Sarah G. Lee, Karin E.J. Rödström, Simon R. Bushell, David Speedman, Adam Evans, Dong Wang, Didi He, Leela Shrestha, Chady Nasrallah, Nicola A. Burgess-Brown, Timothy R. Dafforn, Elisabeth P. Carpenter, David B. Sauer
Proline is widely known as the only proteogenic amino acid with a secondary amine. In addition to its crucial role in protein structure, the secondary amino acid modulates neurotransmission and regulates the kinetics of signaling proteins. To underst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3dd0b3c1551d3725c4f410b48f6a6e46
https://doi.org/10.1101/2023.05.17.541173
https://doi.org/10.1101/2023.05.17.541173
Autor:
Gamma Chi, Qiansheng Liang, Akshay Sridhar, John B. Cowgill, Kasim Sader, Mazdak Radjainia, Pu Qian, Pablo Castro-Hartmann, Shayla Venkaya, Nanki Kaur Singh, Gavin McKinley, Alejandra Fernandez-Cid, Shubhashish M. M. Mukhopadhyay, Nicola A. Burgess-Brown, Lucie Delemotte, Manuel Covarrubias, Katharina L. Dürr
Publikováno v:
Nature Communications
Kv3 channels have distinctive gating kinetics tailored for rapid repolarization in fast-spiking neurons. Malfunction of this process due to genetic variants in the KCNC1 gene causes severe epileptic disorders, yet the structural determinants for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f12c53a3703e4b32471ede4830f9bff
https://pubmed.ncbi.nlm.nih.gov/35840565
https://pubmed.ncbi.nlm.nih.gov/35840565
Autor:
William E. P. Greenland, Nicola A. Burgess-Brown, Tina Bohstedt, Eleanor Williams, Rod Chalk, Charlotte Manning, Rama McCrorie, Tiago Moreira, Alejandra Fernández-Cid, Jesse Coker, S.M.M. Mukhopadhyay
Publikováno v:
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-8 (2021)
Communications Biology, Vol 4, Iss 1, Pp 1-8 (2021)
We describe an analytical method for the identification, mapping and relative quantitation of glycopeptides from SARS-CoV-2 Spike protein. The method may be executed using a LC-TOF mass spectrometer, requires no specialized knowledge of glycan analys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58a7999fc5d3b94d5e92b4fc72c09a00
http://europepmc.org/articles/PMC8333269
http://europepmc.org/articles/PMC8333269
Autor:
Rebecca Ebenhoch, S.M.M. Mukhopadhyay, Samira Slimani, Henry Man, Gavin McKinley, Gabriella Reggiano, Patrizia Abrusci, Gamma Chi, Nicola A. Burgess-Brown, Kiran Bountra, Idlir Liko, Alexandre P. Garneau, Ben Tehan, Frank DiMaio, Katharina L. Dürr, Ali Jazayeri, Carol V. Robinson, Alejandra Fernández-Cid, Laurence E. Tremblay, Tina Bohstedt, Christophe P Moreau, Julie L. Lavoie, Xingyu Qiu, Haiping Tang, Dong Wang, Fernando G. Almeida, Paul Isenring
Publikováno v:
The EMBO Journal
'EMBO Journal ', vol: 40, pages: e107294-1-e107294-20 (2021)
EMBO J
'EMBO Journal ', vol: 40, pages: e107294-1-e107294-20 (2021)
EMBO J
Potassium-coupled chloride transporters (KCCs) play crucial roles in regulating cell volume and intracellular chloride concentration. They are characteristically inhibited under isotonic conditions via phospho-regulatory sites located within the cyto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3901c064e34846dc7faf110fe142fdee
https://doi.org/10.15252/embj.2020107294
https://doi.org/10.15252/embj.2020107294