Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Nicola A Lindsay"'
Autor:
Sébastien L, Degorce, Rana, Anjum, Andrew, Bloecher, Rodrigo J, Carbajo, Keith S, Dillman, Lisa, Drew, Christopher T, Halsall, Eva M, Lenz, Nicola A, Lindsay, Michele F, Mayo, Jennifer H, Pink, Graeme R, Robb, Alan, Rosen, James S, Scott, Yafeng, Xue
Publikováno v:
Journal of medicinal chemistry. 62(21)
In this article, we report the discovery of a series of 5-azaquinazolines as selective IRAK4 inhibitors. From modestly potent quinazoline
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8929c269d95a7fdb4b89ef21869d21c5
https://pubmed.ncbi.nlm.nih.gov/31622099
https://pubmed.ncbi.nlm.nih.gov/31622099
Autor:
David F. Fischer, Ruishuang Geng, Daniel H-C Chen, Krista Ouwehand, Esmieu William R K, Krzysztof Palczewski, Masaru Miyagi, Faywell Albertus, Suhasini R. Gopal, Andrew Pate Owens, Guilian Tian, Roland Bürli, Yoshikazu Imanishi, Angus M MacLeod, Kumar N. Alagramam, Nicola A Lindsay, Richard Lee, William E. Harte, Ina Nemet, Karine Fabienne Malagu, Christopher James Lock
Publikováno v:
Nature Chemical Biology. 12:444-451
Usher syndrome type III (USH3), characterized by progressive deafness, variable balance disorder and blindness, is caused by destabilizing mutations in the gene encoding the clarin-1 (CLRN1) protein. Here we report a new strategy to mitigate hearing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd625ab815b871a28799293b9f41b5a7
https://doi.org/10.1038/nchembio.2069
https://doi.org/10.1038/nchembio.2069
Autor:
James S, Scott, Sébastien L, Degorce, Rana, Anjum, Janet, Culshaw, Robert D M, Davies, Nichola L, Davies, Keith S, Dillman, James E, Dowling, Lisa, Drew, Andrew D, Ferguson, Sam D, Groombridge, Christopher T, Halsall, Julian A, Hudson, Scott, Lamont, Nicola A, Lindsay, Stacey K, Marden, Michele F, Mayo, J Elizabeth, Pease, David R, Perkins, Jennifer H, Pink, Graeme R, Robb, Alan, Rosen, Minhui, Shen, Claire, McWhirter, Dedong, Wu
Publikováno v:
Journal of medicinal chemistry. 60(24)
Herein we report the optimization of a series of pyrrolopyrimidine inhibitors of interleukin-1 receptor associated kinase 4 (IRAK4) using X-ray crystal structures and structure based design to identify and optimize our scaffold. Compound 28 demonstra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d0123c6a11a82f0bdcbd73931a51e9a3
https://pubmed.ncbi.nlm.nih.gov/29172502
https://pubmed.ncbi.nlm.nih.gov/29172502