Výsledky vyhledávání - "Nicola A Irvine"

Akademický článek

Vascular dysfunction induced in offspring by maternal dietary fat involves altered arterial polyunsaturated fatty acid biosynthesis.

Autor: Christopher J Kelsall, Samuel P Hoile, Nicola A Irvine, Mojgan Masoodi, Christopher Torrens, Karen A Lillycrop, Philip C Calder, Geraldine F Clough, Mark A Hanson, Graham C Burdge

Publikováno v: PLoS ONE, Vol 7, Iss 4, p e34492 (2012)

Nutrition during development affects risk of future cardiovascular disease. Relatively little is known about whether the amount and type of fat in the maternal diet affect vascular function in the offspring. To investigate this, pregnant and lactatin

Externí odkaz: https://doaj.org/article/a0c577fd1fc54c9184075dc376e5c946

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Akademický článek

Oxylipin secretion by human CD3+ T lymphocytes in vitro is modified by the exogenous essential fatty acid ratio and life stage

Autor: Johanna von Gerichten, Annette L. West, Nicola A. Irvine, Elizabeth A. Miles, Philip C. Calder, Karen A. Lillycrop, Graham C. Burdge, Barbara A. Fielding

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

Immune function changes across the life stages; for example, senior adults exhibit a tendency towards a weaker cell-mediated immune response and a stronger inflammatory response than younger adults. This might be partly mediated by changes in oxylipi

Externí odkaz: https://doaj.org/article/49889a51f4af4d36bcb198ad532c0087

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Akademický článek

Fatty acid composition and metabolic partitioning of α-linolenic acid are contingent on life stage in human CD3+ T lymphocytes

Autor: Annette L. West, Johanna von Gerichten, Nicola A. Irvine, Elizabeth A. Miles, Karen A. Lillycrop, Philip C. Calder, Barbara A. Fielding, Graham C. Burdge

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

IntroductionImmune function changes across the life course; the fetal immune system is characterised by tolerance while that of seniors is less able to respond effectively to antigens and is more pro-inflammatory than in younger adults. Lipids are in

Externí odkaz: https://doaj.org/article/adc829dcb3514a6e9c3b6ff1a052bb6a

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Akademický článek

The Partitioning of Newly Assimilated Linoleic and α-Linolenic Acids Between Synthesis of Longer-Chain Polyunsaturated Fatty Acids and Hydroxyoctadecaenoic Acids Is a Putative Branch Point in T-Cell Essential Fatty Acid Metabolism

Autor: Johanna von Gerichten, Annette L. West, Nicola A. Irvine, Elizabeth A. Miles, Philip C. Calder, Karen A. Lillycrop, Barbara A. Fielding, Graham C. Burdge

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

Longer-chain polyunsaturated fatty acids (LCPUFAs) ≥20 carbons long are required for leukocyte function. These can be obtained from the diet, but there is some evidence that leukocytes can convert essential fatty acids (EFAs) into LCPUFAs. We used

Externí odkaz: https://doaj.org/article/b8a2cba2a0af44c8b88383c9394d7c7a

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Akademický článek

Polyunsaturated Fatty Acid Biosynthesis Involving Δ8 Desaturation and Differential DNA Methylation of FADS2 Regulates Proliferation of Human Peripheral Blood Mononuclear Cells

Autor: Charlene M. Sibbons, Nicola A. Irvine, J. Eduardo Pérez-Mojica, Philip C. Calder, Karen A. Lillycrop, Barbara A. Fielding, Graham C. Burdge

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

Polyunsaturated fatty acids (PUFAs) are important for immune function. Limited evidence indicates that immune cell activation involves endogenous PUFA synthesis, but this has not been characterised. To address this, we measured metabolism of 18:3n-3

Externí odkaz: https://doaj.org/article/a2774fddb8d8462ab9ce9cd70c2c5036

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How does polyunsaturated fatty acid biosynthesis regulate T lymphocyte function?

Autor: Graham C. Burdge, Barbara A. Fielding, Elizabeth A. Miles, Nicola A. Irvine, J. von Gerichten, Philip C. Calder, Karen A. Lillycrop

mpaired regulation of immune function characterised by chronic inflammation together with a declining protective immune response is a major challenge to healthy ageing. It is therefore important to understand the mechanisms that regulate immune funct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::975d2eb3f37b64e63f0729520db08c86
https://eprints.soton.ac.uk/435510/

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Transcriptome-wide analysis suggests that temporal changes in the relative contributions of hyperplasia, hypertrophy and apoptosis underlie liver growth in pregnant mice†

Autor: Leonie R Price, Karen A. Lillycrop, Nicola A. Irvine, Mark A. Hanson, Graham C. Burdge

Publikováno v: Biology of Reproduction. 97:762-771

Maternal liver undergoes structural and metabolic changes during pregnancy to meet the demands of the developing fetus. In rodents, this involves increased liver weight, but the mechanism remains unclear. To address this, we analyzed the histology, g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8f4bcec9f1b7428bc141260e04750c5
https://doi.org/10.1093/biolre/iox136

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Dietary Fish Oil Alters DNA Methylation of Genes Involved in Polyunsaturated Fatty Acid Biosynthesis in Muscle and Liver of Atlantic Salmon (Salmo salar)

Autor: Graham C. Burdge, Tone-Kari K Østbye, Bente Ruyter, Gerd Marit Berge, Nicola A. Irvine, Karen A. Lillycrop, Anna K Sonesson

Publikováno v: Lipids

Adequate dietary supply of eicosapentanoic acid (20:5n-3) and docosahexaenoic acid (22:6n-3) is required to maintain health and growth of Atlantic salmon (Salmo salar). However, salmon can also convert α-linolenic acid (18:3n-3) to eicosapentanoic a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9acc04f7b9130670042d0b6dc1f28175
https://pubmed.ncbi.nlm.nih.gov/31658496

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