Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Nicola A Cook"'
Autor:
Ren Ren, Shenglin Cai, Xiaona Fang, Xiaoyi Wang, Zheng Zhang, Micol Damiani, Charlotte Hudlerova, Annachiara Rosa, Joshua Hope, Nicola J. Cook, Peter Gorelkin, Alexander Erofeev, Pavel Novak, Anjna Badhan, Michael Crone, Paul Freemont, Graham P. Taylor, Longhua Tang, Christopher Edwards, Andrew Shevchuk, Peter Cherepanov, Zhaofeng Luo, Weihong Tan, Yuri Korchev, Aleksandar P. Ivanov, Joshua B. Edel
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract We report on single-molecule nanopore sensing combined with position-encoded DNA molecular probes, with chemistry tuned to simultaneously identify various antigen proteins and multiple RNA gene fragments of SARS-CoV-2 with high sensitivity a
Externí odkaz:
https://doaj.org/article/1aeae1396aa84739853d9656c3d758c3
Autor:
Allison Ballandras-Colas, Vidya Chivukula, Dominika T. Gruszka, Zelin Shan, Parmit K. Singh, Valerie E. Pye, Rebecca K. McLean, Gregory J. Bedwell, Wen Li, Andrea Nans, Nicola J. Cook, Hind J. Fadel, Eric M. Poeschla, David J. Griffiths, Javier Vargas, Ian A. Taylor, Dmitry Lyumkis, Hasan Yardimci, Alan N. Engelman, Peter Cherepanov
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The authors determined high-resolution cryo-EM structures of the lentiviral intasome — the nucleoprotein complex that inserts viral DNA into a host chromosome — and show that the architecture comprising 16 integrase subunits is critical for its f
Externí odkaz:
https://doaj.org/article/38b768c566d24b6c8e369c087cb41667
Autor:
Eleanor Parker, Jordan Thomas, Kelly J. Roper, Samreen Ijaz, Tansy Edwards, Federica Marchesin, Ksenia Katsanovskaja, Lauren Lett, Christopher Jones, Hayley E. Hardwick, Chris Davis, Elen Vink, Sarah E. McDonald, Shona C. Moore, Steve Dicks, Keerthana Jegatheesan, Nicola J. Cook, Joshua Hope, Peter Cherepanov, Myra O. McClure, J. Kenneth Baillie, Peter J. M. Openshaw, Lance Turtle, Antonia Ho, Malcolm G. Semple, William A. Paxton, Richard S. Tedder, Georgios Pollakis, ISARIC4C Investigators
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The SARS-CoV-2 pandemic enables the analysis of immune responses induced against a novel coronavirus infecting immunologically naïve individuals. This provides an opportunity for analysis of immune responses and associations with age, sex and diseas
Externí odkaz:
https://doaj.org/article/a240e6b9bd6a4eef8a86c9b57f47b940
Autor:
Matthew R. Singer, Tung Dinh, Lev Levintov, Arun S. Annamalai, Juan S. Rey, Lorenzo Briganti, Nicola J. Cook, Valerie E. Pye, Ian A. Taylor, Kyungjin Kim, Alan N. Engelman, Baek Kim, Juan R. Perilla, Mamuka Kvaratskhelia, Peter Cherepanov
Publikováno v:
mBio, Vol 14, Iss 1 (2023)
ABSTRACT Allosteric HIV-1 integrase (IN) inhibitors (ALLINIs) are an emerging class of small molecules that disrupt viral maturation by inducing the aberrant multimerization of IN. Here, we present cocrystal structures of HIV-1 IN with two potent ALL
Externí odkaz:
https://doaj.org/article/18637d366ddf46828152a6725c46c973
Autor:
Francis H.X. Yap, MBBS, Deborah Olsson-White, MBBS, FRACP, Janet Roddy, MD, FRACP, Nicola J. Cook, BM, MRCP, FRACP, D. Robert Langlands, MBBS, FRACP, Prue J. Manners, MD, FRACP, Graeme J. Carroll, MD, FRACP
Publikováno v:
Mayo Clinic Proceedings: Innovations, Quality & Outcomes, Vol 5, Iss 3, Pp 574-582 (2021)
Objective: To assess the outcome of empirical therapeutic interventions for synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome. Methods: The clinical features and treatment outcomes of a cohort of 21 patients diagnosed with SAPH
Externí odkaz:
https://doaj.org/article/ca93e1a304864a1296b9dc0fbcbd5d0d
Autor:
Guru V. Radhakrishnan, Nicola M. Cook, Vanessa Bueno-Sancho, Clare M. Lewis, Antoine Persoons, Abel Debebe Mitiku, Matthew Heaton, Phoebe E. Davey, Bekele Abeyo, Yoseph Alemayehu, Ayele Badebo, Marla Barnett, Ruth Bryant, Jeron Chatelain, Xianming Chen, Suomeng Dong, Tina Henriksson, Sarah Holdgate, Annemarie F. Justesen, Jay Kalous, Zhensheng Kang, Szymon Laczny, Jean-Paul Legoff, Driecus Lesch, Tracy Richards, Harpinder S. Randhawa, Tine Thach, Meinan Wang, Mogens S. Hovmøller, David P. Hodson, Diane G. O. Saunders
Publikováno v:
BMC Biology, Vol 17, Iss 1, Pp 1-17 (2019)
Abstract Background Effective disease management depends on timely and accurate diagnosis to guide control measures. The capacity to distinguish between individuals in a pathogen population with specific properties such as fungicide resistance, toxin
Externí odkaz:
https://doaj.org/article/593d182826a04135a98613e2c122557f
Autor:
Ngonidzashe Kangara, Tomasz J. Kurowski, Guru V. Radhakrishnan, Sreya Ghosh, Nicola M. Cook, Guotai Yu, Sanu Arora, Brian J. Steffenson, Melania Figueroa, Fady Mohareb, Diane G. O. Saunders, Brande B. H. Wulff
Publikováno v:
Frontiers in Plant Science, Vol 11 (2020)
Wheat stem rust caused by the fungus Puccinia graminis f. sp. tritici (Pgt), is regaining prominence due to the recent emergence of virulent isolates and epidemics in Africa, Europe and Central Asia. The development and deployment of wheat cultivars
Externí odkaz:
https://doaj.org/article/926ff219a0c0434c8089f8e55ef913d1
Autor:
Graeme J Carroll, Janet Roddy, Deborah Olsson-White, Francis H.X. Yap, Prue J. Manners, D. Robert Langlands, Nicola J. Cook
Publikováno v:
Mayo Clinic Proceedings: Innovations, Quality & Outcomes, Vol 5, Iss 3, Pp 574-582 (2021)
Mayo Clinic Proceedings: Innovations, Quality & Outcomes
Mayo Clinic Proceedings: Innovations, Quality & Outcomes
Objective To assess the outcome of empirical therapeutic interventions for synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome. Methods The clinical features and treatment outcomes of a cohort of 21 patients diagnosed with SAPHO
Autor:
Pablo del Cerro, Nicola M. Cook, Rik Huisman, Pierre Dangeville, Lauren E. Grubb, Clemence Marchal, Anson Ho Ching Lam, Myriam Charpentier
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(13)
Significance Oscillations in intracellular calcium concentration play an essential role in the regulation of multiple cellular processes. In plants capable of root endosymbiosis with nitrogen-fixing bacteria and/or arbuscular mycorrhizal fungi, nucle
Autor:
Paul S, Dobbin, Louise H, Warren, Nicola J, Cook, Alastair G, McEwan, Anne K, Powell, David J, Richardson
Publikováno v:
Microbiology (Reading, England). 142(4)
The photosynthetic proteobacterium