Zobrazeno 1 - 10
of 247
pro vyhledávání: '"Nicola A, Colabufo"'
Autor:
Laura Braconi, Chiara Riganti, Astrid Parenti, Marta Cecchi, Alessio Nocentini, Gianluca Bartolucci, Marta Menicatti, Marialessandra Contino, Nicola Antonio Colabufo, Dina Manetti, Maria Novella Romanelli, Claudiu T. Supuran, Elisabetta Teodori
Publikováno v:
Molecules, Vol 29, Iss 14, p 3290 (2024)
A new series of piperazine derivatives were synthesized and studied with the aim of obtaining dual inhibitors of P-glycoprotein (P-gp) and carbonic anhydrase XII (hCA XII) to synergistically overcome the P-gp-mediated multidrug resistance (MDR) in ca
Externí odkaz:
https://doaj.org/article/7f0fc90ebe6b4e25b07123ec416bb9e1
Autor:
Francesca Serena Abatematteo, Pietro Delre, Ivan Mercurio, Veronica V. Rezelj, Dritan Siliqi, Stephanie Beaucourt, Gianluca Lattanzi, Nicola Antonio Colabufo, Marcello Leopoldo, Michele Saviano, Marco Vignuzzi, Giuseppe Felice Mangiatordi, Carmen Abate
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract The development of effective drugs to treat coronavirus infections remains a significant challenge for the scientific community. Recent evidence reports on the sigma-1 receptor (S1R) as a key druggable host protein in the SARS-CoV-1 and SARS
Externí odkaz:
https://doaj.org/article/165bc5a82cb64f1eb1159816b6b1c11a
Autor:
Diellza Bajrami, Syed Imdadul Hossain, Alexia Barbarossa, Maria Chiara Sportelli, Rosaria Anna Picca, Luigi Gentile, Francesco Mastrolonardo, Antonio Rosato, Alessia Carocci, Nicola Antonio Colabufo, Boris Mizaikoff, Nicola Cioffi
Publikováno v:
Heliyon, Vol 10, Iss 3, Pp e25260- (2024)
This study explores how a simple argentometric titration-like approach could be evolved into a versatile, scalable, fast, and robust strategy for the production of AgCl/quaternary ammonium compounds (QACs) colloidal nanoantimicrobials (NAMs). These s
Externí odkaz:
https://doaj.org/article/b4d0818322a24ae68f7a72ba244243f8
Autor:
Alisa A. Nevskaya, Rosa Purgatorio, Tatiana N. Borisova, Alexey V. Varlamov, Lada V. Anikina, Arina Yu. Obydennik, Elena Yu. Nevskaya, Mauro Niso, Nicola A. Colabufo, Antonio Carrieri, Marco Catto, Modesto de Candia, Leonid G. Voskressensky, Cosimo D. Altomare
Publikováno v:
Pharmaceuticals, Vol 17, Iss 4, p 539 (2024)
Previous studies have shown that some lamellarin-resembling annelated azaheterocyclic carbaldehydes and related imino adducts, sharing the 1-phenyl-5,6-dihydropyrrolo[2,1-a]isoquinoline (1-Ph-DHPIQ) scaffold, are cytotoxic in some tumor cells and may
Externí odkaz:
https://doaj.org/article/2d6fcacd9a5e4820a808bb200d14b6c9
Autor:
Mariarita Laforgia, Loredana Amodio, Santina Colangiulo, Valentina Ungaro, Letizia Gatti, Gianpiero Lucarelli, Marcello Leopoldo, Patrizia Nardulli, Nicola A. Colabufo
Publikováno v:
ACS Omega, Vol 7, Iss 29, Pp 25239-25243 (2022)
Externí odkaz:
https://doaj.org/article/dab9d1184c694ac2b4685d68f8dd90a9
Autor:
Stefania De Santis, Pasquale Crupi, Laura Piacente, Anna Mestice, Nicola Antonio Colabufo, Loredana Amodio, Paola Pontrelli, Loreto Gesualdo, Antonio Moschetta, Maria Lisa Clodoveo, Maria Felicia Faienza, Filomena Corbo
Publikováno v:
Frontiers in Nutrition, Vol 9 (2022)
Obesity represents an important public health challenge of the twenty first century reaching epidemic proportions worldwide; this is especially true for the pediatric population. In this context, bioactive compounds from foods are crucial to countera
Externí odkaz:
https://doaj.org/article/0193a5cbcf2a4ce5b05e74db68509d4a
Autor:
Veronica Caratelli, Maria Moccia, Francesca R. Paggioro, Luca Fiore, Concetta Avitabile, Michele Saviano, Anna Lisa Imbriani, Principia Dardano, Luca De Stefano, Danila Moscone, Nicola A. Colabufo, Imane Ghafir El Idrissi, Francesco Russo, Giuseppe Riezzo, Gianluigi Giannelli, Fabiana Arduini
Publikováno v:
Advanced NanoBiomed Research, Vol 2, Iss 9, Pp n/a-n/a (2022)
Coeliac disease is a very common autoimmune disease estimated to affect 1 in 100 people worldwide. It occurs in genetically predisposed people where the ingestion of gluten leads to damage in the small intestine, and it is accurately diagnosticated t
Externí odkaz:
https://doaj.org/article/a9d11e4ea8c64fca9d6491eb185d70c2
Publikováno v:
EJNMMI Research, Vol 10, Iss 1, Pp 1-11 (2020)
Abstract Introduction [18F]MC225 is a selective substrate for P-glycoprotein (P-gp) that has good metabolic stability and shows higher baseline uptake compared with other P-gp substrates such as (R)-[11C]Verapamil. Prior to clinical translation, it i
Externí odkaz:
https://doaj.org/article/85bc3dc1359b416aadde97599108780b
Autor:
Laura Braconi, Gianluca Bartolucci, Marialessandra Contino, Niccolò Chiaramonte, Roberta Giampietro, Dina Manetti, Maria Grazia Perrone, Maria Novella Romanelli, Nicola Antonio Colabufo, Chiara Riganti, Silvia Dei, Elisabetta Teodori
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 974-992 (2020)
Aiming to deepen the structure–activity relationships of the two P-glycoprotein (P-gp) modulators elacridar and tariquidar, a new series of amide and ester derivatives carrying a 6,7-dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline scaffold lin
Externí odkaz:
https://doaj.org/article/80d6ac8beb384353b1f30d4afc238f16
Autor:
Ignazio Schino, Mariangela Cantore, Modesto de Candia, Cosimo D. Altomare, Catarina Maria, João Barros, Vasco Cachatra, Patrícia Calado, Karina Shimizu, Adilson A. Freitas, Maria C. Oliveira, Maria J. Ferreira, José N. C. Lopes, Nicola A. Colabufo, Amélia P. Rauter
Publikováno v:
Pharmaceuticals, Vol 16, Iss 1, p 54 (2022)
Alzheimer’s Disease (AD) is characterized by a progressive cholinergic neurotransmission imbalance, with a decrease of acetylcholinesterase (AChE) activity followed by a significant increase of butyrylcholinesterase (BChE) in the later AD stages. B
Externí odkaz:
https://doaj.org/article/8753f9e020ec4afba27fb390b5193167