Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Nicola, Sassi"'
Autor:
Lucia Biasutto, Mario Zoratti, Cristina Paradisi, Martina La Spina, Andrea Mattarei, Michele Azzolini, Nicola Sassi, Matteo Romio
Publikováno v:
Annals of the New York Academy of Sciences. 1403:27-37
Prodrugs of resveratrol are under development. Among the long-term goals, still largely elusive, are (1) modulating physical properties (e.g., water-soluble derivatives bearing polyethylene glycol chains), (2) changing distribution in the body (e.g.,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8084c436fedc35db1dba0d9a60b4f42f
https://doi.org/10.1111/nyas.13401
https://doi.org/10.1111/nyas.13401
Autor:
Lucia Biasutto, Nicola Sassi, Virginia Espina, Mario Zoratti, Andrea Mattarei, Lance A. Liotta, Cristina Paradisi
Publikováno v:
Pharmacological research. 124
Quercetin is a redox-active plant-derived flavonoid with potential anticancer effects, stemming largely from its interaction with a number of proteins, and in particular from inhibition of pro-life kinases. To improve efficacy, we reasoned that a loc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae0190570bb305a4c1d627125b35fceb
https://pubmed.ncbi.nlm.nih.gov/28728925
https://pubmed.ncbi.nlm.nih.gov/28728925
Autor:
Cristina Paradisi, Michele Azzolini, Nicola Sassi, Andrea Mattarei, Mario Zoratti, Ildikò Szabò, Lucia Biasutto
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1837(10):1781-1789
We recently reported that mitochondria-targeted derivatives of resveratrol are cytotoxic in vitro, selectively inducing mostly necrotic death of fast-growing and tumoral cells when supplied in the low μM range (N. Sassi et al., Curr. Pharm. Des. 201
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f49b361d58ee3eb12a4495f207fa1769
Autor:
Mario Zoratti, Massimo Carraro, Lucia Biasutto, Andrea Mattarei, Michele Azzolini, Nicola Sassi, Cristina Paradisi
Publikováno v:
Molecular Pharmaceutics. 10:2781-2792
The pharmacological exploitation of resveratrol is hindered by rapid phase-II conjugative metabolism in enterocytes and hepatocytes. One approach to the solution of this problem relies on prodrugs. We report the synthesis and characterization as well
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ec1dd974bafc479ef75c16c14218b68
https://doi.org/10.1021/mp400226p
https://doi.org/10.1021/mp400226p
Autor:
Lucia, Biasutto, Andrea, Mattarei, Michele, Azzolini, Martina, La Spina, Nicola, Sassi, Matteo, Romio, Cristina, Paradisi, Mario, Zoratti
Prodrugs of resveratrol are under development. Among the long-term goals, still largely elusive, are (1) modulating physical properties (e.g., water-soluble derivatives bearing polyethylene glycol chains), (2) changing distribution in the body (e.g.,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::5f20fd844b9f610e159b6dfe1b9b36b1
http://hdl.handle.net/11577/3243449
http://hdl.handle.net/11577/3243449
Autor:
Spiridione Garbisa, Andrea Mattarei, Anna Citta, Valentina Giorgio, Ildikò Szabò, Paolo Bernardi, Massimo Carraro, Lucia Biasutto, Mario Zoratti, Nicola Sassi, Cristina Paradisi
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1817(7):1095-1106
The mitochondriotropic compound 7-O-(4-triphenylphosphoniumbutyl)quercetin iodide (Q-7BTPI) in the μM concentration range caused necrotic death of cultured cells by acting as a prooxidant, with generation of superoxide anion in the mitochondria. Ext
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db50edb84c914df3ca25a0d18e69f720
Autor:
Christian Durante, Andrea Mattarei, Spiridione Garbisa, Armando Gennaro, Giancarlo Sandonà, Cristina Paradisi, Lucia Biasutto, Nicola Sassi, Mario Zoratti, Ester Marotta
Publikováno v:
European Journal of Organic Chemistry. 2011:5577-5586
Mitochondria-targeted redox-active polyphenol derivatives are being developed to affect redox processes in the organelles and as tools either to protect cells from oxidative damage or to precipitate their death. The properties of such compounds may b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8128e0ab210c8fe5a0ab8394d744a09
https://doi.org/10.1002/ejoc.201100573
https://doi.org/10.1002/ejoc.201100573
Autor:
Spiridione Garbisa, Lucia Biasutto, Cristina Paradisi, Antonio Toninello, Ester Marotta, Paola Cattelan, Andrea Mattarei, Mario Zoratti, Nicola Sassi
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1797(2):189-196
Mitochondria-targeted polyphenols are being developed with the intent to intervene on the levels of reactive oxygen species (ROS) in mitochondria. Polyphenols being more than just anti-oxidants, the interaction of these derivatives with the organelle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2ed48a3147e976639d76df04bdd5d02
Autor:
K. George Chandy, Mario Zoratti, Ildikò Szabò, Luigi Leanza, Brian Henry, Nicola Sassi, Erich Gulbins
Publikováno v:
Leanza, Luigi; Henry, Brian; Sassi, Nicola; Zoratti, Mario; Chandy, K. George; Gulbins, Erich; et al.(2012). Inhibitors of mitochondrial Kv1.3 channels induce Bax/Bak-independent death of cancer cells. EMBO Molecular Medicine, 4(7), 577-593. doi: 10.1002/emmm.201200235. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/56k7p9tm
EMBO Molecular Medicine
EMBO Molecular Medicine
Overcoming the resistance of tumours to chemotherapy, often due to downregulation of Bax and Bak, represents a significant clinical challenge. It is therefore important to identify novel apoptosis inducers that bypass Bax and Bak. Potassium channels
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd5b8195764cdadc1d282cf9cfb21e97
http://www.escholarship.org/uc/item/56k7p9tm
http://www.escholarship.org/uc/item/56k7p9tm