Zobrazeno 1 - 10 of 40 pro vyhledávání: '"Nicola, Salvarese"'
1
Akademický článek
Development of 177Lu-scFvD2B as a Potential Immunotheranostic Agent for Tumors Overexpressing the Prostate Specific Membrane Antigen
Autor: Debora Carpanese, Guillermina Ferro-Flores, Blanca Ocampo-Garcia, Clara Santos-Cuevas, Nicola Salvarese, Mariangela Figini, Giulio Fracasso, Laura De Nardo, Cristina Bolzati, Antonio Rosato, Laura Meléndez-Alafort
Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Abstract The clinical translation of theranostic 177Lu-radiopharmaceuticals based on inhibitors of the prostate-specific membrane antigen (PSMA) has demonstrated positive clinical responses in patients with advanced prostate cancer (PCa). However, ch
Externí odkaz: https://doaj.org/article/9b2d1ad6b66740dab5e3f6564255938b
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2
Akademický článek
Impact of Different [Tc(N)PNP]-Scaffolds on the Biological Properties of the Small cRGDfK Peptide: Synthesis, In Vitro and In Vivo Evaluations
Autor: Nicola Salvarese, Debora Carpanese, Laura Meléndez-Alafort, Laura De Nardo, Andrea Calderan, Barbara Biondi, Paolo Ruzza, Antonio Rosato, Cristina Bolzati
Publikováno v: Molecules, Vol 27, Iss 8, p 2548 (2022)
Background: The [99mTc][Tc(N)(PNP)] system, where PNP is a bisphosphinoamine, is an interesting platform for the development of tumor ‘receptor-specific’ agents. Here, we compared the reactivity and impact of three [Tc(N)(PNP)] frameworks on the
Externí odkaz: https://doaj.org/article/624b5dfef7824c07b6bc0cf22645f34f
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3
Akademický článek
A Review on the Current State and Future Perspectives of [99mTc]Tc-Housed PSMA-i in Prostate Cancer
Autor: Sara Brunello, Nicola Salvarese, Debora Carpanese, Carolina Gobbi, Laura Melendez-Alafort, Cristina Bolzati
Publikováno v: Molecules, Vol 27, Iss 9, p 2617 (2022)
Recently, prostate-specific membrane antigen (PSMA) has gained momentum in tumor nuclear molecular imaging as an excellent target for both the diagnosis and therapy of prostate cancer. Since 2008, after years of preclinical research efforts, a plenti
Externí odkaz: https://doaj.org/article/f336efa2ba0042f4a15569a5cc37cbba
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4
Copper(II) and copper(I) complexes with a bidentate hydrazinic dithiocarbazate: synthesis and crystal structures
Autor: Michele Di Palma, Nicola Salvarese, Carolina Gobbi, Alessandro Dolmella, Cristina Bolzati
In this work, we explored the ability of N-methyl-S-methyl dithiocarbazate ([H2N-N(CH3)C(=S)SCH3]; DTCZ) to form coordination complexes with copper starting from different copper (II, I) sources. Data proved that the type of used salt affects the sto
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::969806c6976f1965f4ad43416f902b2f
https://doi.org/10.26434/chemrxiv-2023-gxkj5
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7
[99mTc][Tc(N)(DASD)(PNPn)]+ (DASD = 1,4-Dioxa-8-azaspiro[4,5]decandithiocarbamate, PNPn = Bisphosphinoamine) for Myocardial Imaging: Synthesis, Pharmacological and Pharmacokinetic Studies
Autor: Cristina Bolzati, Laura Meléndez-Alafort, Nicola Salvarese, Gabriele Gerardi, Cristina Marzano, Davide Carta
Publikováno v: Journal of medicinal chemistry 61 (2018): 11114–11126. doi:10.1021/acs.jmedchem.8b01191
info:cnr-pdr/source/autori:Salvarese N.; Carta D.; Marzano C.; Gerardi G.; Melendez-Alafort L.; Bolzati C./titolo:[ 99m Tc][Tc(N)(DASD)(PNP n)] + (DASD = 1,4-Dioxa-8-azaspiro[4,5]decandithiocarbamate, PNP n = Bisphosphinoamine) for Myocardial Imaging: Synthesis, Pharmacological and Pharmacokinetic Studies/doi:10.1021%2Facs.jmedchem.8b01191/rivista:Journal of medicinal chemistry/anno:2018/pagina_da:11114/pagina_a:11126/intervallo_pagine:11114–11126/volume:61
[Tc-99m][TcN-DBODC(5) is the lead candidate of a class of cationic complexes proposed as myocardial imaging agents (MPIAs). Phase I clinical studies showed that its clinical properties were comparable to those of the commercially available agents. Th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::631e5c343246b5172ac13045f82c2adc
https://doi.org/10.1021/acs.jmedchem.8b01191
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8
Transglutaminase-mediated conjugation and nitride-technetium-99m labelling of a bis(thiosemicarbazone) bifunctional chelator
Autor: Fiorenzo Refosco, Sergio Tamburini, Cristina Bolzati, A. Pasin, Alessandro Galenda, Barbara Spolaore, Selena Marangoni, Nicola Salvarese, Gianfranco Cicoria
Publikováno v: Journal of inorganic biochemistry 183 (2018): 18–31. doi:10.1016/j.jinorgbio.2018.02.023
info:cnr-pdr/source/autori:Salvarese N.; Spolaore B.; Marangoni S.; Pasin A.; Galenda A.; Tamburini S.; Cicoria G.; Refosco F.; Bolzati C./titolo:Transglutaminase-mediated conjugation and nitride-technetium-99m labelling of a bis(thiosemicarbazone) bifunctional chelator/doi:10.1016%2Fj.jinorgbio.2018.02.023/rivista:Journal of inorganic biochemistry/anno:2018/pagina_da:18/pagina_a:31/intervallo_pagine:18–31/volume:183
An assessment study involving the use of the transglutaminase (TGase) conjugation method and the nitride-technetium-99m labelling on a bis(thiosemicarbazone) (BTS) bifunctional chelating agent is presented. The previously described chelator diacetyl-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f304b7a360dc13cc67c34cc46dd09e7
https://doi.org/10.1016/j.jinorgbio.2018.02.023
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9
Targeting prostate cancer with the anti-PSMA scFvD2B: a theranostic promise for nuclear medicine
Autor: Laura Evangelista, Alessandra Zorz, Nicola Salvarese, Debora Carpanese
Despite the significant research activity in the design and validation of new PSMA-targeting agents, prostate cancer (PCa) remains the second most common cancer in men worldwide. PSMA-specific labeled monoclonal antibodies (mAbs) demonstrated a discr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a60f2f69237d38818e69b4d668f5d3b
http://hdl.handle.net/11577/3341844
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10
Improved synthesis on solid phase of dithiocarbamic cRGD-derivative and
Autor: Andrea, Caporale, Cristina, Bolzati, Giuseppina Maria, Incisivo, Nicola, Salvarese, Paolo, Grieco, Menotti, Ruvo
Publikováno v: Journal of peptide science : an official publication of the European Peptide Society. 25(2)
In the field of angiogenesis, small cyclic pentapeptides containing the RGD motif are playing a relevant role for their high affinity and specificity for integrin receptors and for the possibility to act at both therapeutic and diagnostic level by in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e9a36b86959bc674b5024f78d51abdfc
https://pubmed.ncbi.nlm.nih.gov/30680876
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