Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Nicola, Principe"'
Autor:
Elly Marcq, Anna K Nowak, W Joost Lesterhuis, Caitlin M Tilsed, Nicola Principe, Amber-Lee Phung, Kofi L P Stevens, Omar Elaskalani, Ben Wylie, Fezaan Sheikh, M Lizeth Orozco Morales, Joel Kidman, Scott A Fisher, Alison M McDonnell, Jonathan Chee
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 9 (2024)
Background Antibodies that target immune checkpoints such as cytotoxic T lymphocyte antigen 4 (CTLA-4), programmed cell death protein/ligand 1 (PD-1/PD-L1) are approved for treatment of multiple cancer types. Chemotherapy is often administered with i
Externí odkaz:
https://doaj.org/article/7f07a0c5e8004791ac4fe2312e89506b
Autor:
Joel Kidman, Rachael M. Zemek, John-William Sidhom, Debora Correa, Nicola Principe, Fezaan Sheikh, Vanessa S. Fear, Catherine A. Forbes, Abha Chopra, Louis Boon, Ayham Zaitouny, Emma de Jong, Robert A. Holt, Matt Jones, Michael J. Millward, Timo Lassmann, Alistair R.R. Forrest, Anna K. Nowak, Mark Watson, Richard A. Lake, W. Joost Lesterhuis, Jonathan Chee
Publikováno v:
OncoImmunology, Vol 13, Iss 1 (2024)
ABSTRACTImmune checkpoint therapy (ICT) causes durable tumour responses in a subgroup of patients, but it is not well known how T cell receptor beta (TCRβ) repertoire dynamics contribute to the therapeutic response. Using murine models that exclude
Externí odkaz:
https://doaj.org/article/f60545e051804f9796499b61db90824e
Autor:
Nicola Principe, Wayne J. Aston, Danika E. Hope, Caitlin M. Tilsed, Scott A. Fisher, Louis Boon, Ian M. Dick, Wee Loong Chin, Alison M. McDonnell, Anna K. Nowak, Richard A. Lake, Jonathan Chee, Willem Joost Lesterhuis
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Antibodies that target immune checkpoints such as cytotoxic T lymphocyte antigen 4 (CTLA‐4) and the programmed cell death protein 1/ligand 1 (PD-1/PD-L1) are now a treatment option for multiple cancer types. However, as a monotherapy, objective res
Externí odkaz:
https://doaj.org/article/eebc1cc11d8240f49cafed6001ba43c0
Autor:
Jonathan Chee, Chelsea Wilson, Anthony Buzzai, Ben Wylie, Catherine A Forbes, Mitchell Booth, Nicola Principe, Bree Foley, Mark N Cruickshank, Jason Waithman
Publikováno v:
Epigenetics, Vol 15, Iss 1-2, Pp 134-144 (2020)
Activation of naïve CD8+ T cells stimulates proliferation and differentiation into cytotoxic T-lymphocytes (CTLs). Adoptive T Cell Therapy (ACT) involves multiple rounds of ex vivo activation to generate enough CTLs for reinfusion into patients, but
Externí odkaz:
https://doaj.org/article/d828f4c443114fb39e8b6402758650c5
Autor:
Tingting Ge, Amber‐Lee Phung, Gaurang Jhala, Prerak Trivedi, Nicola Principe, David J De George, Evan G Pappas, Sara Litwak, Laura Sanz‐Villanueva, Tara Catterall, Stacey Fynch, Louis Boon, Thomas W Kay, Jonathan Chee, Balasubramanian Krishnamurthy, Helen E Thomas
Publikováno v:
Clinical & Translational Immunology, Vol 11, Iss 11, Pp n/a-n/a (2022)
Abstract Objectives Immune checkpoint inhibitors have achieved clinical success in cancer treatment, but this treatment causes immune‐related adverse events, including type 1 diabetes (T1D). Our aim was to test whether a JAK1/JAK2 inhibitor, effect
Externí odkaz:
https://doaj.org/article/2f238a260da54aefb12d7ef799742c6b
Autor:
Nicola Principe, Joel Kidman, Richard A. Lake, Willem Joost Lesterhuis, Anna K. Nowak, Alison M. McDonnell, Jonathan Chee
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
The success of immunotherapy that targets inhibitory T cell receptors for the treatment of multiple cancers has seen the anti-tumor immune response re-emerge as a promising biomarker of response to therapy. Longitudinal characterization of T cells in
Externí odkaz:
https://doaj.org/article/b452737bea3b422982a78da7a248010f
Autor:
Nicola Principe, Joel Kidman, Siting Goh, Caitlin M. Tilsed, Scott A. Fisher, Vanessa S. Fear, Catherine A. Forbes, Rachael M. Zemek, Abha Chopra, Mark Watson, Ian M. Dick, Louis Boon, Robert A. Holt, Richard A. Lake, Anna K. Nowak, Willem Joost Lesterhuis, Alison M. McDonnell, Jonathan Chee
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Immune checkpoint therapy (ICT) results in durable responses in individuals with some cancers, but not all patients respond to treatment. ICT improves CD8+ cytotoxic T lymphocyte (CTL) function, but changes in tumor antigen-specific CTLs post-ICT tha
Externí odkaz:
https://doaj.org/article/14028b32db2541389131a67ac973ccfb
Autor:
Joel Kidman, Nicola Principe, Mark Watson, Timo Lassmann, Robert A. Holt, Anna K. Nowak, Willem Joost Lesterhuis, Richard A. Lake, Jonathan Chee
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Immunotherapies have revolutionized cancer treatment. In particular, immune checkpoint therapy (ICT) leads to durable responses in some patients with some cancers. However, the majority of treated patients do not respond. Understanding immune mechani
Externí odkaz:
https://doaj.org/article/3fbe5a39f1c84d9fb46f15d98279e862
Autor:
Joel Kidman, Rachael Zemek, Nicola Principe, Debora Correa, Fezaan Sheikh, Vanessa Fear, Catherine Forbes, Abha Chopra, Louis Boon, Emma de Jong, Ayham Zaitouny, Robert Holt, Matt Jones, Michael Millward, Timo Lassmann, Alistair Forrest, Anna Nowak, Mark Watson, Richard Lake, W.Joost Lesterhuis, Jonathan Chee
Immune checkpoint therapy (ICT) causes durable tumor responses in a subgroup of patients. Profiling T cell receptor beta (TCRβ) repertoire structure in ICT responders and non-responders provides mechanistic insight into what constitutes an effective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efebbda04a528e36c044ac09ef4ae5f3
https://doi.org/10.21203/rs.3.rs-1613398/v1
https://doi.org/10.21203/rs.3.rs-1613398/v1
CD4+ T cells drive an inflammatory, TNF-α/IFN-rich tumor microenvironment responsive to chemotherapy
Autor:
Caitlin M. Tilsed, Nicola Principe, Joel Kidman, Wee Loong Chin, M. Lizeth Orozco Morales, Rachael M. Zemek, Jonathan Chee, Rasa Islam, Vanessa S. Fear, Catherine Forbes, Wayne J. Aston, Maud Jansen, Abha Chopra, Timo Lassmann, Anna K. Nowak, Scott A. Fisher, Richard A. Lake, W. Joost Lesterhuis
Publikováno v:
Cell Reports. 41:111874
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b586841e71962346e6664062e52b3bb
https://doi.org/10.1016/j.celrep.2022.111874
https://doi.org/10.1016/j.celrep.2022.111874