Zobrazeno 1 - 10
of 114
pro vyhledávání: '"Nicola, Perrotti"'
Autor:
Alexandra Hochstetler, Hillary Smith, Makenna Reed, Louise Hulme, Paul Territo, Amanda Bedwell, Scott Persohn, Nicola Perrotti, Lucia D’Antona, Francesca Musumeci, Silvia Schenone, Bonnie L. Blazer-Yost
Publikováno v:
Fluids and Barriers of the CNS, Vol 20, Iss 1, Pp 1-14 (2023)
Abstract Background Hydrocephalus is a pathological accumulation of cerebrospinal fluid (CSF), leading to ventriculomegaly. Hydrocephalus may be primary or secondary to traumatic brain injury, infection, or intracranial hemorrhage. Regardless of caus
Externí odkaz:
https://doaj.org/article/8074d949e52d428b89b2452191283773
Autor:
Carolina Brescia, Vincenzo Dattilo, Lucia D’Antona, Emanuela Chiarella, Rossana Tallerico, Salvatore Audia, Valentina Rocca, Rodolfo Iuliano, Francesco Trapasso, Nicola Perrotti, Rosario Amato
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The Th17+ arrangement is critical for orchestrating both innate and acquired immune responses. In this context, the serum and glucocorticoid regulated kinase 1 (SGK1) exerts a key role in the governance of IL-23R-dependent Th17+ maturation, through t
Externí odkaz:
https://doaj.org/article/7f096d7da09943c9bf2415dd907f4548
Autor:
Lucia D’Antona, Rosario Amato, Carolina Brescia, Valentina Rocca, Emma Colao, Rodolfo Iuliano, Bonnie L. Blazer-Yost, Nicola Perrotti
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 6, p 5276 (2023)
Over the years, several studies have shown that kinase-regulated signaling pathways are involved in the development of rare genetic diseases. The study of the mechanisms underlying the onset of these diseases has opened a possible way for the develop
Externí odkaz:
https://doaj.org/article/547350cd22ef4cb7b51f6e6421573025
Autor:
Milena Crippa, Paola Malatesta, Maria Teresa Bonati, Francesco Trapasso, Francesco Fortunato, Grazia Annesi, Lidia Larizza, Angelo Labate, Palma Finelli, Nicola Perrotti, Antonio Gambardella
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 7, Iss 5, Pp 855-859 (2020)
Abstract Three relatives carrying a t(4;8)(p15.2;p23.2) translocation had juvenile myoclonic epilepsy, self‐limited photosensitive occipital epilepsy and migraine with aura. The t(4;8) translocation interrupted the coding sequence of CSMD1 gene and
Externí odkaz:
https://doaj.org/article/d6e5e20d676c49ef88a6eacec7429917
Autor:
Francesco Paduano, Fernanda Fabiani, Emma Colao, Francesco Trapasso, Nicola Perrotti, Vito Barbieri, Francesco Baudi, Rodolfo Iuliano
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Li–Fraumeni syndrome (LFS) is an inherited autosomal dominant disease characterized by a predisposition to many cancers. Germline pathogenic variants in TP53 are primarily responsible for LFS. By performing a targeted sequencing panel in a proband
Externí odkaz:
https://doaj.org/article/e037c0bbe8d04381a7b47587a8766635
Autor:
Valeria Lucchino, Luana Scaramuzzino, Stefania Scalise, Katia Grillone, Michela Lo Conte, Claudia Esposito, Umberto Aguglia, Edoardo Ferlazzo, Nicola Perrotti, Paola Malatesta, Elvira Immacolata Parrotta, Giovanni Cuda
Publikováno v:
Stem Cell Research, Vol 53, Iss , Pp 102329- (2021)
Unverricht-Lundborg disease (ULD) is an inherited form of progressive myoclonus epilepsy caused by mutations in the gene encoding Cystatin B (CSTB), an inhibitor of lysosomal proteases. The most common mutation described in ULD patients is an unstabl
Externí odkaz:
https://doaj.org/article/2cda4cafb2f6426f83e831cd6607d212
Autor:
Lucia D'Antona, Vincenzo Dattilo, Giada Catalogna, Domenica Scumaci, Claudia Vincenza Fiumara, Francesca Musumeci, Giuseppe Perrotti, Silvia Schenone, Rossana Tallerico, Cristina B. Spoleti, Nicola Costa, Rodolfo Iuliano, Giovanni Cuda, Rosario Amato, Nicola Perrotti
Publikováno v:
Translational Oncology, Vol 12, Iss 8, Pp 1045-1055 (2019)
Ovarian cancer is the second most common gynecological malignancy worldwide. Paclitaxel is particularly important in the therapy of ovarian carcinomas, but the treatment efficacy is counteracted by the development of resistance to chemotherapy. The i
Externí odkaz:
https://doaj.org/article/3c41f9ca9a444ed5aac8f25d512325d2
Autor:
Silvia Matteoni, Claudia Abbruzzese, Paola Matarrese, Gabriele De Luca, Anna M. Mileo, Stefania Miccadei, Silvia Schenone, Francesca Musumeci, Tobias L. Haas, Giovanni Sette, Carmine M. Carapella, Rosario Amato, Nicola Perrotti, Michele Signore, Marco G. Paggi
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-13 (2019)
Abstract Background Glioblastoma multiforme (GBM), due to its location, aggressiveness, heterogeneity and infiltrative growth, is characterized by an exceptionally dismal clinical outcome. The small molecule SI113, recently identified as a SGK1 inhib
Externí odkaz:
https://doaj.org/article/8dfab95bdda44c31997c397c85d0687d
Autor:
Rosario Amato, Vincenzo Dattilo, Carolina Brescia, Lucia D’Antona, Rodolfo Iuliano, Francesco Trapasso, Nicola Perrotti, Davide Costa, Nicola Ielapi, Francesco Aiello, Michele Provenzano, Umberto Marcello Bracale, Michele Andreucci, Raffaele Serra
Publikováno v:
Biomolecules, Vol 12, Iss 7, p 902 (2022)
Chronic venous disease is a condition globally widespread, resulting in a disabling pathological disorder. The CD4 + Th17+ (Cluster Differentiation 4) lymphocytes represent a regulative factor for innate immunity related to the development of complex
Externí odkaz:
https://doaj.org/article/a9ec678f3e8848c08e896c79f5038c58
Autor:
Stefania Scalise, Luana Scaramuzzino, Valeria Lucchino, Claudia Esposito, Paola Malatesta, Katia Grillone, Nicola Perrotti, Giovanni Cuda, Elvira Immacolata Parrotta
Publikováno v:
Stem Cell Research, Vol 49, Iss , Pp 102083- (2020)
Here, we described the generation of human induced pluripotent stem cell lines (hiPSCs) from fibroblasts isolated by punch biopsies of two siblings carrying inherited mutation (c.434 T > C) in the SCN1A gene, encoding for the neuronal voltage gated s
Externí odkaz:
https://doaj.org/article/1e27504d898d498da44ee1e5ea86caf7