Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Nicola, O'Reilly"'
Autor:
Hermaleigh Townsley, Joshua Gahir, Timothy W Russell, David Greenwood, Edward J Carr, Matala Dyke, Lorin Adams, Murad Miah, Bobbi Clayton, Callie Smith, Mauro Miranda, Harriet V Mears, Chris Bailey, James R M Black, Ashley S Fowler, Margaret Crawford, Katalin Wilkinson, Matthew Hutchinson, Ruth Harvey, Nicola O'Reilly, Gavin Kelly, Robert Goldstone, Rupert Beale, Padmasayee Papineni, Tumena Corrah, Richard Gilson, Simon Caidan, Jerome Nicod, Steve Gamblin, George Kassiotis, Vincenzo Libri, Bryan Williams, Sonia Gandhi, Adam J Kucharski, Charles Swanton, David L V Bauer, Emma C Wall
Publikováno v:
PLoS ONE, Vol 19, Iss 3, p e0294897 (2024)
BackgroundSARS-CoV-2 variant Omicron rapidly evolved over 2022, causing three waves of infection due to sub-variants BA.1, BA.2 and BA.4/5. We sought to characterise symptoms and viral loads over the course of COVID-19 infection with these sub-varian
Externí odkaz:
https://doaj.org/article/95e0348e63df41608cfccc1b745cbb54
Autor:
Timothy W Russell, Hermaleigh Townsley, Sam Abbott, Joel Hellewell, Edward J Carr, Lloyd A C Chapman, Rachael Pung, Billy J Quilty, David Hodgson, Ashley S Fowler, Lorin Adams, Chris Bailey, Harriet V Mears, Ruth Harvey, Bobbi Clayton, Nicola O'Reilly, Yenting Ngai, Jerome Nicod, Steve Gamblin, Bryan Williams, Sonia Gandhi, Charles Swanton, Rupert Beale, David L V Bauer, Emma C Wall, Adam J Kucharski
Publikováno v:
PLoS Biology, Vol 22, Iss 1, p e3002463 (2024)
The emergence of successive Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) during 2020 to 2022, each exhibiting increased epidemic growth relative to earlier circulating variants, has created a need to underst
Externí odkaz:
https://doaj.org/article/cfe2aa3e3c23488697cdd2e92920d429
Autor:
Mohamed Ismail, Stephen R. Martin, Roger George, Francesca Houghton, Geoff Kelly, Raphaël A. G. Chaleil, Panayiotis Anastasiou, Xinyue Wang, Nicola O’Reilly, Stefania Federico, Dhira Joshi, Hemavathi Nagaraj, Rachel Cooley, Ning Sze Hui, Miriam Molina-Arcas, David C. Hancock, Ali Tavassoli, Julian Downward
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract P110α is a member of the phosphoinositide 3-kinase (PI3K) enzyme family that functions downstream of RAS. RAS proteins contribute to the activation of p110α by interacting directly with its RAS binding domain (RBD), resulting in the promot
Externí odkaz:
https://doaj.org/article/6034fbcb86144639966ed92b541f75ef
Autor:
Steven Lynham, Fabio Grundland Freile, Natasha M. Puri, Nicola O’Reilly, Graham H. Mitchell, Timothy N. C. Wells, Merlin Willcox, Richard Beatson
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
Abstract The discovery of compounds and proteins from plants has greatly contributed to modern medicine. Vernonia amygdalina Del. (Compositae) is used by humans and primates for a variety of conditions including parasitic infection. This paper descri
Externí odkaz:
https://doaj.org/article/edb0bc195dac42f384074befbd859da7
Autor:
Yuguang Zhao, Laura-Nadine Schuhmacher, Morgan Roberts, Satoshi Kakugawa, Ganka Bineva-Todd, Steve Howell, Nicola O'Reilly, Christine Perret, Ambrosius P. Snijders, Jean-Paul Vincent, E. Yvonne Jones
Publikováno v:
Molecular Metabolism, Vol 49, Iss , Pp 101201- (2021)
Objectives: The only proteins known to be modified by O-linked lipidation are Wnts and ghrelin, and enzymatic removal of this post-translational modification inhibits ligand activity. Indeed, the Wnt-deacylase activity of Notum is the basis of its ab
Externí odkaz:
https://doaj.org/article/c594c909a4894de098721bcad79aabdb
Autor:
Martina Wirth, Wenxin Zhang, Minoo Razi, Lynet Nyoni, Dhira Joshi, Nicola O’Reilly, Terje Johansen, Sharon A. Tooze, Stéphane Mouilleron
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Autophagy adaptors and receptors contain LC3-interacting region (LIR) motifs that bind selectively to the LIR docking site of GABARAP and other members of the ATG8 family. Here the authors show that in addition to the LIR motif also the region C-term
Externí odkaz:
https://doaj.org/article/61625672f9c642f79baf4e0b2c21a97b
Autor:
M. Teresa Bertran, Stéphane Mouilleron, Yanxiang Zhou, Rakhi Bajaj, Federico Uliana, Ganesan Senthil Kumar, Audrey van Drogen, Rebecca Lee, Jennifer J. Banerjee, Simon Hauri, Nicola O’Reilly, Matthias Gstaiger, Rebecca Page, Wolfgang Peti, Nicolas Tapon
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
Serine/threonine phosphatases such as PP1 associate with a large array of subunit proteins, such as ASPP (apoptosis-stimulating protein of p53) to achieve selective targeting. Here authors solved the crystal structure of the human ASPP2/PP1 complex a
Externí odkaz:
https://doaj.org/article/6895486193a040a6ada179998498e708
Autor:
Michael D. Buck, Enzo Z. Poirier, Ana Cardoso, Bruno Frederico, Johnathan Canton, Sam Barrell, Rupert Beale, Richard Byrne, Simon Caidan, Margaret Crawford, Laura Cubitt, Sonia Gandhi, Robert Goldstone, Paul R. Grant, Kiran Gulati, Steve Hindmarsh, Michael Howell, Michael Hubank, Rachael Instrell, Ming Jiang, George Kassiotis, Wei-Ting Lu, James I. MacRae, Iana Martini, Davin Miller, David Moore, Eleni Nastouli, Jerome Nicod, Luke Nightingale, Jessica Olsen, Amin Oomatia, Nicola O'Reilly, Anett Rideg, Ok-Ryul Song, Amy Strange, Charles Swanton, Samra Turajlic, Mary Wu, Caetano Reis e Sousa, The Crick COVID-19 Consortium
Publikováno v:
Wellcome Open Research, Vol 6 (2021)
The ongoing pandemic of SARS-CoV-2 calls for rapid and cost-effective methods to accurately identify infected individuals. The vast majority of patient samples is assessed for viral RNA presence by RT-qPCR. Our biomedical research institute, in colla
Externí odkaz:
https://doaj.org/article/5ae84b910d3947409230776bdb593363
Autor:
Roman O Fedoryshchak, Magdalena Přechová, Abbey M Butler, Rebecca Lee, Nicola O'Reilly, Helen R Flynn, Ambrosius P Snijders, Noreen Eder, Sila Ultanir, Stephane Mouilleron, Richard Treisman
Publikováno v:
eLife, Vol 9 (2020)
PPP-family phosphatases such as PP1 have little intrinsic specificity. Cofactors can target PP1 to substrates or subcellular locations, but it remains unclear how they might confer sequence-specificity on PP1. The cytoskeletal regulator Phactr1 is a
Externí odkaz:
https://doaj.org/article/d44fd2f8800b402e9a011331fbee17e9
Sotrovimab restores neutralization against current Omicron subvariants in patients with blood cancer
Autor:
Mary Y. Wu, Scott T.C. Shepherd, Annika Fendler, Edward J. Carr, Lewis Au, Ruth Harvey, Giulia Dowgier, Agnieszka Hobbs, Lou S. Herman, Martina Ragno, Lorin Adams, Andreas M. Schmitt, Zayd Tippu, Benjamin Shum, Sheima Farag, Aljosja Rogiers, Nicola O’Reilly, Philip Bawumia, Callie Smith, Eleanor Carlyle, Kim Edmonds, Lyra Del Rosario, Karla Lingard, Mary Mangwende, Lucy Holt, Hamid Ahmod, Justine Korteweg, Tara Foley, Taja Barber, Stephanie Hepworth, Andrea Emslie-Henry, Niamh Caulfield-Lynch, Fiona Byrne, Daqi Deng, Bryan Williams, Michael Brown, Simon Caidan, Mike Gavrielides, James I. MacRae, Gavin Kelly, Kema Peat, Denise Kelly, Aida Murra, Kayleigh Kelly, Molly O’Flaherty, Sanjay Popat, Nadia Yousaf, Shaman Jhanji, Kate Tatham, David Cunningham, Nicholas Van As, Kate Young, Andrew J.S. Furness, Lisa Pickering, Rupert Beale, Charles Swanton, Sonia Gandhi, Steve Gamblin, David L.V. Bauer, George Kassiotis, Michael Howell, Susanna Walker, Emma Nicholson, James Larkin, Emma C. Wall, Samra Turajlic
Publikováno v:
Cancer Cell. 41:821-823
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e6d4243fe5e4c8ad32570daab4a4e35
https://doi.org/10.1016/j.ccell.2023.04.005
https://doi.org/10.1016/j.ccell.2023.04.005