Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Nicola, Giacchè"'
Autor:
Thanalai Poonsiri, Davide Dell’Accantera, Valentina Loconte, Alessandro Casnati, Laura Cervoni, Alessandro Arcovito, Stefano Benini, Alberto Ferrari, Marco Cipolloni, Elisa Cacioni, Francesca De Franco, Nicola Giacchè, Serena Rinaldo, Claudia Folli, Francesco Sansone, Rodolfo Berni, Michele Cianci
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 1, p 479 (2023)
Transthyretin (TTR) is an amyloidogenic homotetramer involved in the transport of thyroxine in blood and cerebrospinal fluid. To date, more than 130 TTR point mutations are known to destabilise the TTR tetramer, leading to its extracellular pathologi
Externí odkaz:
https://doaj.org/article/656d5dbbb7e544f2a6912ca4c7534197
Autor:
Michele Cianci, Nicola Giacchè, Lucia Cialabrini, Andrea Carotti, Paride Liscio, Emiliano Rosatelli, Francesca De Franco, Massimiliano Gasparrini, Janet Robertson, Adolfo Amici, Nadia Raffaelli, Roberto Pellicciari
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Human α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase (ACMSD) stands at a branch point of the de novo NAD+ synthesis pathway and plays an important role in maintaining NAD+ homeostasis. It has been recently identified as a novel therapeutic
Externí odkaz:
https://doaj.org/article/939b4944020c4a4f9cf2c164cbbc4724
Autor:
Fabiola Moretti, Antonio Macchiarulo, Jean Christophe Marine, Alfredo Pontecorvi, Roberto Pellicciari, Giulia Piaggio, Mara D'Onofrio, Maurizio Fanciulli, Tiziana Bruno, Rossella Brandi, Laura Fici, Marianna Buttarelli, Emanuela Teveroni, Fulvio Florenzano, Ivan Arisi, Isabella Manni, Nicola Giacchè, Alice Coletti, Rossella Lucà, Francesca Mancini, Marsha Pellegrino
Supplementary Figures S1-9, Tables S1 and 2. Supplementary Figure S1: Analysis of p53 ubiquitination and binding Supplementary Figure S2: Pep3 activity in human tumor cell lines Supplementary Figure S3: Pep3 activity in untransformed cells Supplement
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86f412cf386837aee8ea282366fd89e0
https://doi.org/10.1158/0008-5472.22405989.v1
https://doi.org/10.1158/0008-5472.22405989.v1
Autor:
Mariagrazia Rullo, Marco Cipolloni, Marco Catto, Carolina Colliva, Daniela Valeria Miniero, Tiziana Latronico, Modesto de Candia, Tiziana Benicchi, Anna Linusson, Nicola Giacchè, Cosimo Damiano Altomare, Leonardo Pisani
Publikováno v:
Journal of Medicinal Chemistry. 65:3962-3977
Bioisosteric H/F or CH
Autor:
Marco Gargaro, Giulia Scalisi, Giorgia Manni, Carlos G. Briseño, Prachi Bagadia, Vivek Durai, Derek J. Theisen, Sunkyung Kim, Marilena Castelli, Chenling A. Xu, Gerd Meyer zu Hörste, Giuseppe Servillo, Maria A. Della Fazia, Giulia Mencarelli, Doriana Ricciuti, Eleonora Padiglioni, Nicola Giacchè, Carolina Colliva, Roberto Pellicciari, Mario Calvitti, Teresa Zelante, Dietmar Fuchs, Ciriana Orabona, Louis Boon, Alban Bessede, Marco Colonna, Paolo Puccetti, Theresa L. Murphy, Kenneth M. Murphy, Francesca Fallarino
Conventional dendritic cells (cDCs), cDC1 and cDC2, act both to initiate immunity and maintain self-tolerance. The tryptophan metabolic enzyme indoleamine 2,3-dioxygenase 1 (IDO1) is used by cDCs in maintaining tolerance, but its role in different su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7fb6c294a099bfdb930d914d491d3a6
https://hdl.handle.net/11391/1535413
https://hdl.handle.net/11391/1535413
Autor:
Carlos L. Manrique-Caballero, Francesca De Franco, Hernando Gomez, Roberto Pellicciari, John A. Kellum, Nicola Giacchè
Publikováno v:
Antioxid Redox Signal
Significance: Acute kidney injury (AKI) is a common and life-threatening complication in hospitalized and critically ill patients. It is defined by an abrupt deterioration in renal function, clinically manifested by increased serum creatinine levels,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c9bee5427ef7fa52c74ab011c040bdc
https://europepmc.org/articles/PMC8905249/
https://europepmc.org/articles/PMC8905249/
Autor:
Marika Zietak, Roberto Pellicciari, Nicola Giacchè, Lucia Cialabrini, Adrienne Mottis, Vera van der Velpen, Elena Katsyuba, Nadia Raffaelli, Paride Liscio, Nadine Stokar-Regenscheit, Johan Auwerx, Julijana Ivanisevic, David Legouis, Kristina Schoonjans, Karim Gariani, Francesca De Franco, Sophie de Seigneux, Olli Matilainen, Dongryeol Ryu
Publikováno v:
Nature
Nature, vol. 563, no. 7731, pp. 354-359
Nature, Vol. 563, No 7731 (2018) pp. 354-359
Nature, vol. 563, no. 7731, pp. 354-359
Nature, Vol. 563, No 7731 (2018) pp. 354-359
Nicotinamide adenine dinucleotide (NAD + ) is a co-substrate for several enzymes, including the sirtuin family of NAD + -dependent protein deacylases. Beneficial effects of increased NAD + levels and sirtuin activation on mitochondrial homeostasis, o
Autor:
Francesca Mancini, Rossella Lucà, Roberto Pellicciari, Nicola Giacchè, Marsha Pellegrino, Tiziana Bruno, Mara D'Onofrio, Ivan Arisi, Rossella Brandi, Laura Fici, Alfredo Pontecorvi, Antonio Macchiarulo, Isabella Manni, Jean-Christophe Marine, Marianna Buttarelli, Alice Coletti, Emanuela Teveroni, Fabiola Moretti, Giulia Piaggio, Fulvio Florenzano, Maurizio Fanciulli
Publikováno v:
Cancer research (Chic. Ill.) 75 (2015): 4560–4572. doi:10.1158/0008-5472.CAN-15-0439
info:cnr-pdr/source/autori:Pellegrino, Marsha; Mancini, Francesca; Luca, Rossella; Coletti, Alice; Giacche, Nicola; Manni, Isabella; Arisi, Ivan; Florenzano, Fulvio; Teveroni, Emanuela; Buttarelli, Marianna; Fici, Laura; Brandi, Rossella; Bruno, Tiziana; Fanciulli, Maurizio; D'Onofrio, Mara; Piaggio, Giulia; Pellicciari, Roberto; Pontecorvi, Alfredo; Marine, Jean Christophe; Macchiarulo, Antonio; Moretti, Fabiola/titolo:Targeting the MDM2%2FMDM4 Interaction Interface as a Promising Approach for p53 Reactivation Therapy/doi:10.1158%2F0008-5472.CAN-15-0439/rivista:Cancer research (Chic. Ill.)/anno:2015/pagina_da:4560/pagina_a:4572/intervallo_pagine:4560–4572/volume:75
info:cnr-pdr/source/autori:Pellegrino, Marsha; Mancini, Francesca; Luca, Rossella; Coletti, Alice; Giacche, Nicola; Manni, Isabella; Arisi, Ivan; Florenzano, Fulvio; Teveroni, Emanuela; Buttarelli, Marianna; Fici, Laura; Brandi, Rossella; Bruno, Tiziana; Fanciulli, Maurizio; D'Onofrio, Mara; Piaggio, Giulia; Pellicciari, Roberto; Pontecorvi, Alfredo; Marine, Jean Christophe; Macchiarulo, Antonio; Moretti, Fabiola/titolo:Targeting the MDM2%2FMDM4 Interaction Interface as a Promising Approach for p53 Reactivation Therapy/doi:10.1158%2F0008-5472.CAN-15-0439/rivista:Cancer research (Chic. Ill.)/anno:2015/pagina_da:4560/pagina_a:4572/intervallo_pagine:4560–4572/volume:75
Restoration of wild-type p53 tumor suppressor function has emerged as an attractive anticancer strategy. Therapeutics targeting the two p53-negative regulators, MDM2 and MDM4, have been developed, but most agents selectively target the ability of onl
Autor:
Johan Auwerx, Janet Robertson, Francesca De Franco, Andrea Carotti, Paride Liscio, Nicola Giacchè, Elena Katsyuba, Roberto Pellicciari, Lucia Cialabrini, Nadia Raffaelli
Publikováno v:
Journal of medicinal chemistry. 61(3)
NAD+ has a central function in linking cellular metabolism to major cell-signaling and gene-regulation pathways. Defects in NAD+ homeostasis underpin a wide range of diseases, including cancer, metabolic disorders, and aging. Although the beneficial
Autor:
Elena, Katsyuba, Adrienne, Mottis, Marika, Zietak, Francesca, De Franco, Vera, van der Velpen, Karim, Gariani, Dongryeol, Ryu, Lucia, Cialabrini, Olli, Matilainen, Paride, Liscio, Nicola, Giacchè, Nadine, Stokar-Regenscheit, David, Legouis, Sophie, de Seigneux, Julijana, Ivanisevic, Nadia, Raffaelli, Kristina, Schoonjans, Roberto, Pellicciari, Johan, Auwerx
Publikováno v:
Nature. 563(7731)
Nicotinamide adenine dinucleotide (NAD