Zobrazeno 1 - 10
of 168
pro vyhledávání: '"Nicola, Gagliani"'
Publikováno v:
Gut Microbes, Vol 16, Iss 1 (2024)
ABSTRACTPancreatic ductal adenocarcinoma (PDAC) is an aggressive disease with poor prognosis. This is due to the fact that most cases are only diagnosed at an advanced and palliative disease stage, and there is a high incidence of therapy resistance.
Externí odkaz:
https://doaj.org/article/6fb5cb3a5ed049f781b0ef9f58f63e72
Autor:
Lisa-Marie Rieckmann, Michael Spohn, Lisa Ruff, David Agorku, Lisa Becker, Alina Borchers, Jenny Krause, Roisin O’Reilly, Jurek Hille, Janna-Lisa Velthaus-Rusik, Niklas Beumer, Armin Günther, Lena Willnow, Charles D. Imbusch, Peter Iglauer, Ronald Simon, Sören Franzenburg, Hauke Winter, Michael Thomas, Carsten Bokemeyer, Nicola Gagliani, Christian F. Krebs, Martin Sprick, Olaf Hardt, Sabine Riethdorf, Andreas Trumpp, Nikolas H. Stoecklein, Sven Peine, Philipp Rosenstiel, Klaus Pantel, Sonja Loges, Melanie Janning
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-9 (2024)
Abstract Background Circulating tumor cells (CTCs) hold immense promise for unraveling tumor heterogeneity and understanding treatment resistance. However, conventional methods, especially in cancers like non-small cell lung cancer (NSCLC), often yie
Externí odkaz:
https://doaj.org/article/2c341ef7571b4502937a3beb26a74b4b
Autor:
Fabian Hausmann, Can Ergen, Robin Khatri, Mohamed Marouf, Sonja Hänzelmann, Nicola Gagliani, Samuel Huber, Pierre Machart, Stefan Bonn
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-40 (2023)
Abstract Background Single-cell sequencing provides detailed insights into biological processes including cell differentiation and identity. While providing deep cell-specific information, the method suffers from technical constraints, most notably a
Externí odkaz:
https://doaj.org/article/a37a7fd8e5294ea4979af75cc27ceea2
Autor:
Friederike Stumme, Niklas Steffens, Babett Steglich, Franziska Mathies, Mikolaj Nawrocki, Morsal Sabihi, Shiwa Soukou-Wargalla, Emilia Göke, Jan Kempski, Thorben Fründt, Sören Weidemann, Christoph Schramm, Nicola Gagliani, Samuel Huber, Tanja Bedke
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundPrimary sclerosing cholangitis (PSC) is a chronic liver disease marked by inflammation of the bile ducts and results in the development of strictures and fibrosis. A robust clinical correlation exists between PSC and inflammatory bowel dise
Externí odkaz:
https://doaj.org/article/fe4be545b6ce4708b789790c53a8eb4c
Autor:
Riekje Winzer, Du Hanh Nguyen, Felix Schoppmeier, Filippo Cortesi, Nicola Gagliani, Eva Tolosa
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
An increase in the extracellular concentration of ATP as a consequence of cellular stress or cell death results in the activation of immune cells. To prevent inflammation, extracellular ATP is rapidly metabolized to adenosine, which deploys an anti-i
Externí odkaz:
https://doaj.org/article/5567e81fc7a0470690b8c4265e211e21
Autor:
Tao Zhang, Ramez Wahib, Dimitra E. Zazara, Jöran Lücke, Ahmad Mustafa Shiri, Jan Kempski, Lilan Zhao, Theodora Agalioti, Andres Pablo Machicote, Olympia Giannou, Ioannis Belios, Rongrong Jia, Siwen Zhang, Joseph Tintelnot, Hannes Seese, Julia Kristin Grass, Baris Mercanoglu, Louisa Stern, Pasquale Scognamiglio, Mohammad Fard-Aghaie, Philipp Seeger, Jonas Wakker, Marius Kemper, Benjamin Brunswig, Anna Duprée, Panagis M. Lykoudis, Anastasia Pikouli, Emmanouil Giorgakis, Pablo Stringa, Natalia Lausada, Maria Virginia Gentilini, Gabriel E. Gondolesi, Kai Bachmann, Philipp Busch, Rainer Grotelüschen, Ioannis C. Maroulis, Petra C. Arck, Ryosuke Nakano, Angus W. Thomson, Tarik Ghadban, Michael Tachezy, Nathaniel Melling, Eike-Gert Achilles, Victor G. Puelles, Felix Nickel, Thilo Hackert, Oliver Mann, Jakob R. Izbicki, Jun Li, Nicola Gagliani, Samuel Huber, Anastasios D. Giannou
Publikováno v:
OncoImmunology, Vol 12, Iss 1 (2023)
ABSTRACTMetastasis is a cancer-related systemic disease and is responsible for the greatest mortality rate among cancer patients. Interestingly, the interaction between the immune system and cancer cells seems to play a key role in metastasis formati
Externí odkaz:
https://doaj.org/article/3cee1dcf7a0d46038cb4bbb3cfb81bcf
Autor:
Jonas Wagner, Yogesh Kumar, Anne Lautenbach, Philipp von Kroge, Stefan Wolter, Oliver Mann, Jakob Izbicki, Nicola Gagliani, Anna Duprée
Publikováno v:
Lipids in Health and Disease, Vol 22, Iss 1, Pp 1-9 (2023)
Abstract Background Nonalcoholic fatty liver disease (NAFLD), especially nonalcoholic steatohepatitis (NASH) increases the risk for liver cirrhosis. Noninvasive tests for NAFLD/NASH exist, but they are unreliable and thus liver biopsy remains the sta
Externí odkaz:
https://doaj.org/article/1bb605313f5c406bb8c02e545dd9dc73
Autor:
Steven Schepanski, Mattia Chini, Veronika Sternemann, Christopher Urbschat, Kristin Thiele, Ting Sun, Yu Zhao, Mareike Poburski, Anna Woestemeier, Marie-Theres Thieme, Dimitra E. Zazara, Malik Alawi, Nicole Fischer, Joerg Heeren, Nikita Vladimirov, Andrew Woehler, Victor G. Puelles, Stefan Bonn, Nicola Gagliani, Ileana L. Hanganu-Opatz, Petra C. Arck
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
During pregnancy, maternal cells are transferred to the fetus, where they can reach the developing brain. In this study, the authors demonstrate that these maternal cells play an important role in neurodevelopment.
Externí odkaz:
https://doaj.org/article/f28f78dbe76547abbc4cadf7463e2b41
Autor:
Anastasios D. Giannou, Jan Kempski, Tao Zhang, Jöran Lücke, Ahmad Mustafa Shiri, Dimitra E. Zazara, Ioannis Belios, Andres Machicote, Philipp Seeger, Theodora Agalioti, Joseph Tintelnot, Adrian Sagebiel, Miriam Tomczak, Lennart Bauditz, Tanja Bedke, Lorenz Kocheise, Baris Mercanoglu, Mohammad Fard-Aghaie, Emmanouil Giorgakis, Panagis M. Lykoudis, Anastasia Pikouli, Julia-Kristin Grass, Ramez Wahib, Jan Bardenhagen, Benjamin Brunswig, Asmus Heumann, Tarik Ghadban, Anna Duprée, Michael Tachezy, Nathaniel Melling, Petra C. Arck, Pablo Stringa, Maria Virginia Gentilini, Gabriel E. Gondolesi, Ryosuke Nakano, Angus W. Thomson, Daniel Perez, Jun Li, Oliver Mann, Jakob R. Izbicki, Nicola Gagliani, Ioannis C. Maroulis, Samuel Huber
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
BackgroundThe immune system plays a pivotal role in cancer progression. Interleukin 22 binding protein (IL-22BP), a natural antagonist of the cytokine interleukin 22 (IL-22) has been shown to control the progression of colorectal cancer (CRC). Howeve
Externí odkaz:
https://doaj.org/article/f1277168178b412eb2f6bc3aef5b86d5
Autor:
Sara M. Parigi, Ludvig Larsson, Srustidhar Das, Ricardo O. Ramirez Flores, Annika Frede, Kumar P. Tripathi, Oscar E. Diaz, Katja Selin, Rodrigo A. Morales, Xinxin Luo, Gustavo Monasterio, Camilla Engblom, Nicola Gagliani, Julio Saez-Rodriguez, Joakim Lundeberg, Eduardo J. Villablanca
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Abstract The intestinal barrier is composed of a complex cell network defining highly compartmentalized and specialized structures. Here, we use spatial transcriptomics to define how the transcriptomic landscape is spatially organized in the steady s
Externí odkaz:
https://doaj.org/article/f5256a2864b448d09abb930e673fd1f1