Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Nicola, Facchinello"'
Autor:
Raquel Brañas Casas, Alessandro Zuppardo, Giovanni Risato, Alberto Dinarello, Rudy Celeghin, Camilla Fontana, Eleonora Grelloni, Alexandru Ionut Gilea, Carlo Viscomi, Andrea Rasola, Luisa Dalla Valle, Tiziana Lodi, Enrico Baruffini, Nicola Facchinello, Francesco Argenton, Natascia Tiso
Publikováno v:
Cell Death and Disease, Vol 15, Iss 4, Pp 1-12 (2024)
Abstract The human mitochondrial DNA polymerase gamma is a holoenzyme, involved in mitochondrial DNA (mtDNA) replication and maintenance, composed of a catalytic subunit (POLG) and a dimeric accessory subunit (POLG2) conferring processivity. Mutation
Externí odkaz:
https://doaj.org/article/58a56ab3a25547089b9f2b151454fd8b
Autor:
Rudy Celeghin, Giovanni Risato, Giorgia Beffagna, Marco Cason, Maria Bueno Marinas, Mila Della Barbera, Nicola Facchinello, Alice Giuliodori, Raquel Brañas Casas, Micol Caichiolo, Andrea Vettori, Enrico Grisan, Stefania Rizzo, Luisa Dalla Valle, Francesco Argenton, Gaetano Thiene, Natascia Tiso, Kalliopi Pilichou, Cristina Basso
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-14 (2023)
Abstract Arrhythmogenic cardiomyopathy (AC) is an inherited disorder characterized by progressive loss of the ventricular myocardium causing life-threatening ventricular arrhythmias, syncope and sudden cardiac death in young and athletes. About 40% o
Externí odkaz:
https://doaj.org/article/19472e78aa4e4bbcaaac30f07520d4e5
Autor:
Matteo Astone, Chiara Tesoriero, Marco Schiavone, Nicola Facchinello, Natascia Tiso, Francesco Argenton, Andrea Vettori
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 18, p 10005 (2024)
Hippo-YAP/TAZ and Wnt/β-catenin signaling pathways, by controlling proliferation, migration, cell fate, stemness, and apoptosis, are crucial regulators of development and tissue homeostasis. We employed zebrafish embryos as a model system to elucida
Externí odkaz:
https://doaj.org/article/c3269b3b45244b5f8277282aab0f9124
Autor:
Camilla Maria Fontana, Francesca Terrin, Nicola Facchinello, Giacomo Meneghetti, Alberto Dinarello, Lisa Gambarotto, Annalisa Zuccarotto, Micol Caichiolo, Ginevra Brocca, Ranieri Verin, Francesca Nazio, Oliana Carnevali, Francesco Cecconi, Paolo Bonaldo, Luisa Dalla Valle
Publikováno v:
Biological Research, Vol 56, Iss 1, Pp 1-17 (2023)
Abstract Background AMBRA1 is an intrinsically disordered protein, working as a scaffold molecule to coordinate, by protein-protein interaction, many cellular processes, including autophagy, mitophagy, apoptosis and cell cycle progression. The zebraf
Externí odkaz:
https://doaj.org/article/ae5216e6d4bf45f9a757c2b8eedd7f2d
Autor:
Francesca Maradonna, Camilla M. Fontana, Fiorenza Sella, Christian Giommi, Nicola Facchinello, Chiara Rampazzo, Micol Caichiolo, Seyed Hossein Hoseinifar, Luisa Dalla Valle, Hien Van Doan, Oliana Carnevali
Publikováno v:
Cell Death and Disease, Vol 13, Iss 12, Pp 1-11 (2022)
Abstract Colon cancer is one of the leading causes of death worldwide. In recent years, cannabinoids have been extensively studied for their potential anticancer effects and symptom management. Several in vitro studies reported anandamide’s (AEA) a
Externí odkaz:
https://doaj.org/article/17fbb62c6b6e4eda8366bee6cb9de389
Autor:
Camilla M. Fontana, Lisa Locatello, Patrizia Sabatelli, Nicola Facchinello, Elisa Lidron, Francesca Maradonna, Oliana Carnevali, Maria B. Rasotto, Luisa Dalla Valle
Publikováno v:
Biomedical Journal, Vol 45, Iss 2, Pp 377-386 (2022)
Background: Dysregulation of the autophagic flux is linked to a wide array of human diseases, and recent findings highlighted the central role of autophagy in reproduction, as well as an association between impairment of autophagy and behavioural dis
Externí odkaz:
https://doaj.org/article/73a7f944b0fe46c8ae0b8ddf0a988753
Autor:
Chiara Tesoriero, Francesca Greco, Elena Cannone, Francesco Ghirotto, Nicola Facchinello, Marco Schiavone, Andrea Vettori
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 9, p 8314 (2023)
Muscular dystrophies (MDs) are a heterogeneous group of myopathies characterized by progressive muscle weakness leading to death from heart or respiratory failure. MDs are caused by mutations in genes involved in both the development and organization
Externí odkaz:
https://doaj.org/article/dafc1301e856412a985c86a905f89bc7
Autor:
Luca Mignani, Nicola Facchinello, Marco Varinelli, Elena Massardi, Natascia Tiso, Cosetta Ravelli, Stefania Mitola, Peter Schu, Eugenio Monti, Dario Finazzi, Giuseppe Borsani, Daniela Zizioli
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 8, p 7108 (2023)
In vertebrates, two homologous heterotetrameric AP1 complexes regulate the intracellular protein sorting via vesicles. AP-1 complexes are ubiquitously expressed and are composed of four different subunits: γ, β1, μ1 and σ1. Two different complexe
Externí odkaz:
https://doaj.org/article/a4d583b476f24210bdd091760345bb72
Autor:
Nicola Facchinello, Claudio Laquatra, Lisa Locatello, Giorgia Beffagna, Raquel Brañas Casas, Chiara Fornetto, Alberto Dinarello, Laura Martorano, Andrea Vettori, Giovanni Risato, Rudy Celeghin, Giacomo Meneghetti, Massimo Mattia Santoro, Agnes Delahodde, Francesco Vanzi, Andrea Rasola, Luisa Dalla Valle, Maria Berica Rasotto, Tiziana Lodi, Enrico Baruffini, Francesco Argenton, Natascia Tiso
Publikováno v:
Cell Death and Disease, Vol 12, Iss 1, Pp 1-18 (2021)
Abstract The DNA polymerase gamma (Polg) is a nuclear-encoded enzyme involved in DNA replication in animal mitochondria. In humans, mutations in the POLG gene underlie a set of mitochondrial diseases characterized by mitochondrial DNA (mtDNA) depleti
Externí odkaz:
https://doaj.org/article/e5b4a8a5e87b4483a23748afb74ea087
Autor:
Lucia Barazzuol, Domenico Cieri, Nicola Facchinello, Tito Calì, Philip Washbourne, Francesco Argenton, Paola Pizzo
Publikováno v:
Cells, Vol 12, Iss 3, p 376 (2023)
Mutations in presenilin 2 (PS2) have been causally linked to the development of inherited Alzheimer’s disease (AD). Besides its role as part of the γ-secretase complex, mammalian PS2 is also involved, as an individual protein, in a growing number
Externí odkaz:
https://doaj.org/article/d109659f437e4036a6c6316a27dba2fb