Zobrazeno 1 - 10 of 14 pro vyhledávání: '"Nicola, Begley"'
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Akademický článek
Quantification of protein abundance and interaction defines a mechanism for operation of the circadian clock
Autor: Alex A Koch, James S Bagnall, Nicola J Smyllie, Nicola Begley, Antony D Adamson, Jennifer L Fribourgh, David G Spiller, Qing-Jun Meng, Carrie L Partch, Korbinian Strimmer, Thomas A House, Michael H Hastings, Andrew SI Loudon
Publikováno v: eLife, Vol 11 (2022)
The mammalian circadian clock exerts control of daily gene expression through cycles of DNA binding. Here, we develop a quantitative model of how a finite pool of BMAL1 protein can regulate thousands of target sites over daily time scales. We used qu
Externí odkaz: https://doaj.org/article/12909e7319834f59a2d8e05b4469036f
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2
The clock gene Bmal1 inhibits macrophage motility, phagocytosis, and impairs defense against pneumonia
Autor: John Blaikley, Gareth B. Kitchen, Tracy Hussell, Mudassar Iqbal, Robert Maidstone, Laura Matthews, Hannah J. Durrington, Peter S. Cunningham, James Bagnall, Nicola Begley, Matthew Baxter, Ben Saer, Toryn Poolman, Julie E. Gibbs, Andrew S. I. Loudon, David W. Ray, David H. Dockrell
Publikováno v: Kitchen, G B, Cunningham, P S, Poolman, T M, Iqbal, M, Maidstone, R, Baxter, M, Bagnall, J, Begley, N, Saer, B, Hussell, T, Matthews, L C, Dockrell, D H, Durrington, H J, Gibbs, J E, Blaikley, J F, Loudon, A S & Ray, D W 2020, ' The clock gene Bmal1 inhibits macrophage motility, phagocytosis, and impairs defense against pneumonia ', Proceedings of the National Academy of Sciences, vol. 117, no. 3, pp. 1543-1551 . https://doi.org/10.1073/pnas.1915932117
The circadian clock regulates many aspects of immunity. Bacterial infections are affected by time of day, but the mechanisms involved remain undefined. Here we show that loss of the core clock protein BMAL1 in macrophages confers protection against p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f2f3ec07d41a024bb148b8e2b4eb0d7
https://doi.org/10.1073/pnas.1915932117
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3
Quantification of protein abundance and interaction defines a mechanism for operation of the circadian clock
Autor: James S Bagnall, Alex A Koch, Nicola J Smyllie, Nicola Begley, Antony D Adamson, Jennifer L Fribourgh, David G Spiller, Qing-Jun Meng, Carrie L Partch, Korbinian Strimmer, Thomas A House, Michael H Hastings, Andrew SI Loudon
Publikováno v: Koch, A, Bagnall, J, Smyllie, N J, Begley, N, Adamson, A, Fribourgh, J L, Spiller, D, Meng, Q-J, Partch, C L, Strimmer, K, House, T, Hastings, M H & Loudon, A 2022, ' Quantification of protein abundance and interaction defines a mechanism for operation of the circadian clock ', eLife, vol. 11, e73976 . https://doi.org/10.7554/eLife.73976
The mammalian circadian clock exerts control of daily gene expression through cycles of DNA binding. Here, we develop a quantitative model of how a finite pool of BMAL1 protein can regulate thousands of target sites over daily time scales. We used qu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bda5ec2b702d72fdf720c555831088b1
https://research.manchester.ac.uk/en/publications/238e144d-a42e-4255-b827-1bca6bd15350
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6
The circadian clock protein REVERBα inhibits pulmonary fibrosis development
Autor: John Blaikley, Andrew S. I. Loudon, Peter Meijer, Andrew J. Fisher, Karen Piper-Hanley, Neil C. Henderson, Alicja Nazgiewicz, Rajamayier V. Venkateswaran, Gareth B. Kitchen, Martin K. Rutter, James Bagnall, Rachel C. Chambers, Lee A. Borthwick, Boris Hinz, Nicola Begley, Peter S. Cunningham, Rajesh Shah, Julie E. Gibbs, David W. Ray, Simon G. Anderson, Monika Lodyga, Paul F. Mercer, David A. Bechtold, Hannah J. Durrington
Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Cunningham, P, Meijer, P, Nazgiewicz, A, Anderson, S, Borthwick, L A, Bagnall, J, Kitchen, G, Lodyga, M, Begley, N, Venkateswaran, R, Shah, R, Mercer, P F, Durrington, H, Henderson, N, Piper Hanley, K, Fisher, A, Chambers, R C, Bechtold, D, Gibbs, J, Loudon, A, Rutter, M K, Hinz, B, Ray, D & Blaikley, J 2020, ' The circadian clock protein REVERBα inhibits pulmonary fibrosis development ', Proceedings of the National Academy of Sciences, vol. 117, no. 2, pp. 1139-1147 . https://doi.org/10.1073/pnas.1912109117
Cunningham, P S, Meijer, P, Nazgiewicz, A, Anderson, S G, Borthwick, L A, Bagnall, J, Kitchen, G B, Lodyga, M, Begley, N, Venkateswaran, R V, Shah, R, Mercer, P F, Durrington, H J, Henderson, N C, Piper-hanley, K, Fisher, A J, Chambers, R C, Bechtold, D A, Gibbs, J E, Loudon, A S, Rutter, M K, Hinz, B, Ray, D W & Blaikley, J F 2020, ' The circadian clock protein REVERBα inhibits pulmonary fibrosis development ', Proceedings of the National Academy of Sciences, vol. 117, no. 2, pp. 1139-1147 . https://doi.org/10.1073/pnas.1912109117
Significance The circadian clock plays an essential role in energy metabolism and inflammation. In contrast, the importance of the clock in the pathogenesis of fibrosis remains poorly explored. This study describes a striking alteration in circadian
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68c7fdf84cedf5c0195bf8bff0f86ab4
https://doi.org/10.1073/pnas.1912109117
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7
Circadian clock mechanism driving mammalian photoperiodism
Autor: Helen C. Christian, Andrew S. I. Loudon, Matthew Hindle, Yasutaka Mizoro, Dave Burt, Ben Saer, Shona H. Wood, Judith McNeilly, Alan S. McNeilly, Yung Sung Cheng, Katarzyna Miedzinska, Simone Meddle, Nicola Begley
Publikováno v: Wood, S, Hindle, M, Mizoro, Y, Cheng, Y, Saer, B, Miedzinska-Bielecka, K, Christian, H, Begley, N, J, M, McNeilly, A, Meddle, S, Burt, D & Loudon, A 2020, ' Circadian clock mechanism driving mammalian photoperiodism. ', Nature Communications, vol. 11, 4291 (2020), pp. 1-15 . https://doi.org/10.1038/s41467-020-18061-z
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Wood, S, Hindle, M M, Mizoro, Y, Cheng, Y, Saer, B, Miedzinska, K, Christian, H C, Begley, N, McNeilly, J, McNeilly, A S, Meddle, S L, Burt, D W & Loudon, A 2020, ' Circadian clock mechanism driving mammalian photoperiodism ', Nature Communications, vol. 11, 4291 . https://doi.org/10.1038/s41467-020-18061-z
The annual photoperiod cycle provides the critical environmental cue synchronizing rhythms of life in seasonal habitats. In 1936, Bünning proposed a circadian-based coincidence timer for photoperiodic synchronization in plants. Formal studies suppor
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbe68ec4d59282f4ea3b26b1fb3be070
https://hdl.handle.net/20.500.11820/5e075f9c-9115-4113-8aa7-1d78e2ed165d
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8
Ezh2 restrains macrophage inflammatory responses, and is critical for neutrophil migration in response to pulmonary infection
Autor: Thanuja Gali Ramamoorthy, Gareth B. Kitchen, Andrew S. I. Loudon, Polly Downton, David H. Dockrell, Tracy Hussell, Julie E. Gibbs, Thomas Hopwood, David W. Ray, Nicola Begley
Mucosal immunity is critical to survival, with huge attention at present due to the Coronovirus pandemic. Epigenetic factors are increasingly recognized as important determinants of immune responses, and EZH2 closest to application due to the availab
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1f4b79a0700e3b525917bb86dcb39c80
https://doi.org/10.1101/2020.07.24.219154
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9
Circadian asthma airway responses are gated by REV-ERBα
Autor: David W. Ray, John Blaikley, Clare M. Lloyd, Andrew S. I. Loudon, Julie E. Gibbs, Laurence C. Goosey, Peter Meijer, Lisa G. Gregory, Nicola Begley, Hannah J. Durrington, Karolina Krakowiak, Robert Maidstone
Publikováno v: Durrington, H J, Krakowiak, K, Meijer, P, Begley, N, Maidstone, R, Goosey, L, Gibbs, J E, Blaikley, J F, Gregory, L G, Lloyd, C M, Loudon, A S I & Ray, D W 2020, ' Circadian asthma airway responses are gated by REV-ERBα ', European Respiratory Journal, vol. 56, 1902407 . https://doi.org/10.1183/13993003.02407-2019
Eur Respir J
BackgroundAsthma is an inflammatory disease of the airway showing a strong time of day rhythm. Airway hyperresponsiveness is a dominant feature of asthma, but it is not known if this is under clock control. The circadian clock powerfully regulates in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd1407f94ec9f74dac7eb653bd2766f5
https://doi.org/10.1183/13993003.02407-2019
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10
Genome-wide effect of pulmonary airway epithelial cell-specific
Autor: Zhenguang, Zhang, Louise, Hunter, Gang, Wu, Robert, Maidstone, Yasutaka, Mizoro, Ryan, Vonslow, Mark, Fife, Thomas, Hopwood, Nicola, Begley, Ben, Saer, Ping, Wang, Peter, Cunningham, Matthew, Baxter, Hannah, Durrington, John F, Blaikley, Tracy, Hussell, Magnus, Rattray, John B, Hogenesch, Julie, Gibbs, David W, Ray, Andrew S I, Loudon
Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33(5)
Pulmonary airway epithelial cells (AECs) form a critical interface between host and environment. We investigated the role of the circadian clock using mice bearing targeted deletion of the circadian gene brain and muscle ARNT-like 1 (Bmal1) in AECs.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1f4694ab88ad9aacdd3aeb2e8467bde1
https://pubmed.ncbi.nlm.nih.gov/30794439
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