Zobrazeno 1 - 10 of 27 pro vyhledávání: '"Nicola, Beckmann"'
1
Akademický článek
The monothiol glutaredoxin GrxD is essential for sensing iron starvation in Aspergillus fumigatus.
Autor: Matthias Misslinger, Mareike Thea Scheven, Peter Hortschansky, Manuel Sánchez López-Berges, Katharina Heiss, Nicola Beckmann, Thomas Heigl, Martin Hermann, Thomas Krüger, Olaf Kniemeyer, Axel A Brakhage, Hubertus Haas
Publikováno v: PLoS Genetics, Vol 15, Iss 9, p e1008379 (2019)
Efficient adaptation to iron starvation is an essential virulence determinant of the most common human mold pathogen, Aspergillus fumigatus. Here, we demonstrate that the cytosolic monothiol glutaredoxin GrxD plays an essential role in iron sensing i
Externí odkaz: https://doaj.org/article/d31ad98d678b4e83bb0839932928c100
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2
Akademický článek
The Dynamic Influence of Olorofim (F901318) on the Cell Morphology and Organization of Living Cells of Aspergillus fumigatus
Autor: Saskia du Pré, Mike Birch, Derek Law, Nicola Beckmann, Graham E. M. Sibley, Michael J. Bromley, Nick D. Read, Jason D. Oliver
Publikováno v: Journal of Fungi, Vol 6, Iss 2, p 47 (2020)
The first characterized antifungal in the orotomide class is olorofim. It targets the de novo pyrimidine biosynthesis pathway by inhibiting dihydroorotate dehydrogenase (DHODH). The pyrimidines uracil, thymine and cytosine are the building blocks of
Externí odkaz: https://doaj.org/article/aa407e5c7ed14ec7a7370f2aaa5ab714
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3
Akademický článek
A Nonredundant Phosphopantetheinyl Transferase, PptA, Is a Novel Antifungal Target That Directs Secondary Metabolite, Siderophore, and Lysine Biosynthesis in Aspergillus fumigatus and Is Critical for Pathogenicity
Autor: Anna Johns, Daniel H. Scharf, Fabio Gsaller, Hella Schmidt, Thorsten Heinekamp, Maria Straßburger, Jason D. Oliver, Mike Birch, Nicola Beckmann, Katharine S. Dobb, Jane Gilsenan, Bharatkumar Rash, Elaine Bignell, Axel A. Brakhage, Michael J. Bromley
Publikováno v: mBio, Vol 8, Iss 4 (2017)
ABSTRACT Secondary metabolites are key mediators of virulence for many pathogens. Aspergillus fumigatus produces a vast array of these bioactive molecules, the biosynthesis of which is catalyzed by nonribosomal peptide synthetases (NRPSs) or polyketi
Externí odkaz: https://doaj.org/article/cccea62e55644309b3c3b177d1c49935
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4
Akademický článek
Characterisation of the Candida albicans Phosphopantetheinyl Transferase Ppt2 as a Potential Antifungal Drug Target.
Autor: Katharine S Dobb, Sarah J Kaye, Nicola Beckmann, John L Thain, Lubomira Stateva, Mike Birch, Jason D Oliver
Publikováno v: PLoS ONE, Vol 10, Iss 11, p e0143770 (2015)
Antifungal drugs acting via new mechanisms of action are urgently needed to combat the increasing numbers of severe fungal infections caused by pathogens such as Candida albicans. The phosphopantetheinyl transferase of Aspergillus fumigatus, encoded
Externí odkaz: https://doaj.org/article/1cd24085abc54adea0bfd6032719577a
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6
Akademický článek
Targeting iron acquisition blocks infection with the fungal pathogens Aspergillus fumigatus and Fusarium oxysporum.
Autor: Sixto M Leal, Sanhita Roy, Chairut Vareechon, Steven deJesus Carrion, Heather Clark, Manuel S Lopez-Berges, Antonio Di Pietro, Marcus Schrettl, Nicola Beckmann, Bernhard Redl, Hubertus Haas, Eric Pearlman
Publikováno v: PLoS Pathogens, Vol 9, Iss 7, p e1003436 (2013)
Filamentous fungi are an important cause of pulmonary and systemic morbidity and mortality, and also cause corneal blindness and visual impairment worldwide. Utilizing in vitro neutrophil killing assays and a model of fungal infection of the cornea,
Externí odkaz: https://doaj.org/article/d68745bffe404aedb98f88c87cd843dd
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7
Akademický článek
Characterization of the Link between Ornithine, Arginine, Polyamine and Siderophore Metabolism in Aspergillus fumigatus.
Autor: Nicola Beckmann, Lukas Schafferer, Markus Schrettl, Ulrike Binder, Heribert Talasz, Herbert Lindner, Hubertus Haas
Publikováno v: PLoS ONE, Vol 8, Iss 6, p e67426 (2013)
The opportunistic fungal pathogen Aspergillus fumigatus produces siderophores for uptake and storage of iron, which is essential for its virulence. The main precursor of siderophore biosynthesis (SB), ornithine, can be produced from glutamate in the
Externí odkaz: https://doaj.org/article/bd0f74a43e704696a7138bb80d4708d7
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8
The Dynamic Influence of Olorofim (F901318) on the Cell Morphology and Organization of Living Cells of Aspergillus fumigatus
Autor: Nicola Beckmann, Jason David Oliver, Derek Law, Saskia du Pré, Graham Edward Morris Sibley, Mike Birch, Nick D. Read, Michael Bromley
Publikováno v: Journal of Fungi
Volume 6
Issue 2
Journal of Fungi, Vol 6, Iss 47, p 47 (2020)
du Pré, S, Birch, M, Law, D, Beckmann, N, Sibley, G E M, Bromley, M J, Read, N D & Oliver, J D 2020, ' The Dynamic Influence of Olorofim (F901318) on the Cell Morphology and Organization of Living Cells of Aspergillus fumigatus ', Journal of Fungi, vol. 6, no. 2, 47 . https://doi.org/10.3390/jof6020047
The first characterized antifungal in the orotomide class is olorofim. It targets the de novo pyrimidine biosynthesis pathway by inhibiting dihydroorotate dehydrogenase (DHODH). The pyrimidines uracil, thymine and cytosine are the building blocks of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60680e240b11dc692ee749da525e67ef
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9
Akademický článek
SREBP coordinates iron and ergosterol homeostasis to mediate triazole drug and hypoxia responses in the human fungal pathogen Aspergillus fumigatus.
Autor: Michael Blatzer, Bridget M Barker, Sven D Willger, Nicola Beckmann, Sara J Blosser, Elizabeth J Cornish, Aurelien Mazurie, Nora Grahl, Hubertus Haas, Robert A Cramer
Publikováno v: PLoS Genetics, Vol 7, Iss 12, p e1002374 (2011)
Sterol regulatory element binding proteins (SREBPs) are a class of basic helix-loop-helix transcription factors that regulate diverse cellular responses in eukaryotes. Adding to the recognized importance of SREBPs in human health, SREBPs in the human
Externí odkaz: https://doaj.org/article/e51c700efac84a04a167891cb89dc718
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10
Akademický článek
HapX-mediated adaption to iron starvation is crucial for virulence of Aspergillus fumigatus.
Autor: Markus Schrettl, Nicola Beckmann, John Varga, Thorsten Heinekamp, Ilse D Jacobsen, Christoph Jöchl, Tarek A Moussa, Shaohua Wang, Fabio Gsaller, Michael Blatzer, Ernst R Werner, William C Niermann, Axel A Brakhage, Hubertus Haas
Publikováno v: PLoS Pathogens, Vol 6, Iss 9, p e1001124 (2010)
Iron is essential for a wide range of cellular processes. Here we show that the bZIP-type regulator HapX is indispensable for the transcriptional remodeling required for adaption to iron starvation in the opportunistic fungal pathogen Aspergillus fum
Externí odkaz: https://doaj.org/article/feac8ba4ae864815876ffffab965291f
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