Zobrazeno 1 - 10
of 287
pro vyhledávání: '"Nicol Keith"'
Autor:
Alan E. Bilsland, Yu Liu, Andrew Turnbull, David Sumpton, Katrina Stevenson, Claire J. Cairney, Susan M. Boyd, Jon Roffey, David Jenkinson, W. Nicol Keith
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 21, Iss 9, Pp 893-907 (2019)
Telomere signaling and metabolic dysfunction are hallmarks of cell aging. New agents targeting these processes might provide therapeutic opportunities, including chemoprevention strategies against cancer predisposition. We report identification and c
Externí odkaz:
https://doaj.org/article/936206170ac349faab43d8b1ddaedfcd
Autor:
Karin A. Oien, W. Nicol Keith, Christopher Bellamy, Caroline Verbeke, Jacqueline Mooney, Ian Downie, Alexandra K. Bell, Jan Komorowski, Ernst C. Wit, Torgeir R. Hvidsten, Jayne L. Dennis
Purpose: Patients with metastatic adenocarcinoma of unknown origin are a common clinical problem. Knowledge of the primary site is important for their management, but histologically, such tumors appear similar. Better diagnostic markers are needed to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06c64dd357e19c88804d6b69181e4539
https://doi.org/10.1158/1078-0432.c.6518334
https://doi.org/10.1158/1078-0432.c.6518334
Autor:
Karin A. Oien, W. Nicol Keith, Christopher Bellamy, Caroline Verbeke, Jacqueline Mooney, Ian Downie, Alexandra K. Bell, Jan Komorowski, Ernst C. Wit, Torgeir R. Hvidsten, Jayne L. Dennis
Supplementary Figure 1 from Markers of Adenocarcinoma Characteristic of the Site of Origin: Development of a Diagnostic Algorithm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1de19d5d79aa75d79f4c437fc0d672b
https://doi.org/10.1158/1078-0432.22441206
https://doi.org/10.1158/1078-0432.22441206
Autor:
Karin A. Oien, W. Nicol Keith, Christopher Bellamy, Caroline Verbeke, Jacqueline Mooney, Ian Downie, Alexandra K. Bell, Jan Komorowski, Ernst C. Wit, Torgeir R. Hvidsten, Jayne L. Dennis
Supplementary Table 1 from Markers of Adenocarcinoma Characteristic of the Site of Origin: Development of a Diagnostic Algorithm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3890fda40d3f774ca25a1961dca10b4b
https://doi.org/10.1158/1078-0432.22441203
https://doi.org/10.1158/1078-0432.22441203
Autor:
Alan E. Bilsland, Angelo Pugliese, Yu Liu, John Revie, Sharon Burns, Carol McCormick, Claire J. Cairney, Justin Bower, Martin Drysdale, Masashi Narita, Mahito Sadaie, W. Nicol Keith
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 17, Iss 9, Pp 704-715 (2015)
Cellular senescence is a barrier to tumorigenesis in normal cells, and tumor cells undergo senescence responses to genotoxic stimuli, which is a potential target phenotype for cancer therapy. However, in this setting, mixed-mode responses are common
Externí odkaz:
https://doaj.org/article/f63495499283424f8b4feb22d3460e78
Autor:
Claire J Cairney, Lauren S Godwin, Alan E Bilsland, Sharon Burns, Katrina H Stevenson, Lynn McGarry, John Revie, Jon D Moore, Ceri M Wiggins, Rebecca S Collinson, Clare Mudd, Elpida Tsonou, Mahito Sadaie, Dorothy C Bennett, Masashi Narita, Christopher J Torrance, W Nicol Keith
Publikováno v:
PLoS Genetics, Vol 13, Iss 8, p e1006942 (2017)
Senescence is a universal barrier to immortalisation and tumorigenesis. As such, interest in the use of senescence-induction in a therapeutic context has been gaining momentum in the past few years; however, senescence and immortalisation remain unde
Externí odkaz:
https://doaj.org/article/9c37fdc4728e4b2584673b3d2d9b5b8b
Autor:
Boitelo T Letsolo, Rhiannon E Jones, Jan Rowson, Julia W Grimstead, W Nicol Keith, Gareth J S Jenkins, Duncan M Baird
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0174833 (2017)
Barrett's oesophagus is a premalignant metaplastic condition that predisposes patients to the development of oesophageal adenocarcinoma. However, only a minor fraction of Barrett's oesophagus patients progress to adenocarcinoma and it is thus essenti
Externí odkaz:
https://doaj.org/article/d8f9b80fd6ea4b6196df8cda58935a64
Autor:
Nicol Keith
OBJECTIVES The primary objective of this study is: (a) To analyse Relative Telomere Length (RTL) in blood samples taken from patients during chemotherapy for advanced gastro-oesophageal adenocarcinoma. This will allow us to determine if the baseline
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09a3c72a90ff4d52ba77469b85dcbf51
https://doi.org/10.17504/protocols.io.n92ldznenv5b/v1
https://doi.org/10.17504/protocols.io.n92ldznenv5b/v1
Autor:
Nicol Keith
OBJECTIVES The primary objective of this study is: (a) to analyse Relative Telomere Length (RTL) in blood samples taken from patients during peri-operative chemotherapy for operable gastric or gastro-oesophageal junction adenocarcinoma. This will all
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e6beb2ffcf22d631214a84bc6b1525d
https://doi.org/10.17504/protocols.io.ca5csg2w
https://doi.org/10.17504/protocols.io.ca5csg2w