Mapping the DNA Damaging Effects of Polypyridyl Copper Complexes with DNA Electrochemical Biosensors

Autor: Anna Banasiak, Nicolò Zuin Fantoni, Andrew Kellett, John Colleran

Publikováno v: Molecules, Vol 27, Iss 3, p 645 (2022)

Several classes of copper complexes are known to induce oxidative DNA damage that mediates cell death. These compounds are potentially useful anticancer agents and detailed investigation can reveal the mode of DNA interaction, binding strength, and t

Externí odkaz: https://doaj.org/article/c30a3729a667435b8e53e91629a9954f

Enzymatic synthesis of chemical nuclease triplex-forming oligonucleotides with gene-silencing applications

Autor: Bríonna McGorman, Nicolò Zuin Fantoni, Sinéad O’Carroll, Anna Ziemele, Afaf H El-Sagheer, Tom Brown, Andrew Kellett

Triplex-forming oligonucleotides (TFOs) are short, single-stranded oligomers that hybridise to a specific sequence of duplex DNA. TFOs can block transcription and thereby inhibit protein production, making them highly appealing in the field of antige

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37764bd679a09fc4fe4cf65ad7038f46
https://eprints.soton.ac.uk/478406/

Polypyridyl-Based Copper Phenanthrene Complexes: Combining Stability with Enhanced DNA Recognition.

Autor: Fantoni NZ; School of Chemical Sciences and National Institute for Cellular, Biotechnology, Dublin City University, Glasnevin, Dublin, 9, Ireland.; Nicolò Zuin Fantoni-Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK., Molphy Z; School of Chemical Sciences and National Institute for Cellular, Biotechnology, Dublin City University, Glasnevin, Dublin, 9, Ireland.; SSPC, the SFI Research Centre for Pharmaceuticals, School of Chemical Sciences, Dublin City University, Dublin, 9, Ireland., O'Carroll S; School of Chemical Sciences and National Institute for Cellular, Biotechnology, Dublin City University, Glasnevin, Dublin, 9, Ireland., Menounou G; Consiglio Nazionale delle Ricerche, ISOF, Via P. Gobetti 101, 40129, Bologna, Italy., Mitrikas G; Institute of Nanoscience and Nanotechnology Demokritos, NCSR 'Demokritos', Agia Paraskevi Attikis, 153, 10, Athens, Greece., Krokidis MG; Institute of Nanoscience and Nanotechnology Demokritos, NCSR 'Demokritos', Agia Paraskevi Attikis, 153, 10, Athens, Greece., Chatgilialoglu C; Consiglio Nazionale delle Ricerche, ISOF, Via P. Gobetti 101, 40129, Bologna, Italy., Colleran J; School of Chemical and Pharmaceutical Sciences, TU Dublin, Kevin Street, Dublin 8, Ireland.; Applied Electrochemistry Group, Focas Research Institute, TU Dublin, Camden Row, Dublin 8, Ireland., Banasiak A; Applied Electrochemistry Group, Focas Research Institute, TU Dublin, Camden Row, Dublin 8, Ireland., Clynes M; National Institute for Cellular Biotechnology, Dublin City University, Dublin, 9, Ireland., Roche S; National Institute for Cellular Biotechnology, Dublin City University, Dublin, 9, Ireland., Kelly S; National Institute for Cellular Biotechnology, Dublin City University, Dublin, 9, Ireland., McKee V; School of Chemical Sciences and National Institute for Cellular, Biotechnology, Dublin City University, Glasnevin, Dublin, 9, Ireland.; Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Campusvej 55, 5230, Odense M, Denmark., Kellett A; School of Chemical Sciences and National Institute for Cellular, Biotechnology, Dublin City University, Glasnevin, Dublin, 9, Ireland.; SSPC, the SFI Research Centre for Pharmaceuticals, School of Chemical Sciences, Dublin City University, Dublin, 9, Ireland.

Publikováno v: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2021 Jan 13; Vol. 27 (3), pp. 971-983. Date of Electronic Publication: 2020 Oct 22.