Synthesis and Characterization of [MIII(PS)2(L)] Mixed-Ligand Compounds (M = Re, 99Tc; PS = Phosphinothiolate; L = Dithiocarbamate) as Potential Models for the Development of New Agents for SPECT Imaging and Radiotherapy

Autor: Alfonso Venzo, Fiorenzo Refosco, Nicola Salvarese, Nicolò Morellato, Cristina Bolzati, Alessandro Dolmella

Publikováno v: Inorganic chemistry (Online) 52 (2013): 6365–6377. doi:10.1021/ic400094s
info:cnr-pdr/source/autori:Salvarese N.; Morellato N.; Venzo A.; Refosco F.; Dolmella A.; Bolzati C./titolo:Synthesis and Characterization of [MIII(PS)2(L)] mixed-ligand compounds (M = Re, 99Tc; PS= phosphino-thiolate; L= dithiocarbamate) as a model for the Development of New Agents for SPECT Imaging and Radiotherapy/doi:10.1021%2Fic400094s/rivista:Inorganic chemistry (Online)/anno:2013/pagina_da:6365/pagina_a:6377/intervallo_pagine:6365–6377/volume:52

The synthesis and characterization of a new series of neutral, six-coordinated mixed-ligand compounds [M(III)(PS)2(L)] (M = Re; (99)Tc), where PS is bis(arylalkyl)- or trialkylphosphinothiolate and L is dithiocarbamate, are reported. Stable [M(III)(P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e82b297e08f9d0b4605d59fed29d9846
https://doi.org/10.1021/ic400094s

Melanoma targeting with [99mTc(N)(PNP3)]-labeled α-melanocyte stimulating hormone peptide analogs: Effects of cyclization on the radiopharmaceutical properties

Autor: H.-J. Pietzsch, Barbara Biondi, Antonio Rosato, Wiebke Sihver, Feng Gao, Nicola Salvarese, Cristina Bolzati, Davide Carta, Nicolò Morellato, Fiorenzo Refosco, Paolo Ruzza, Debora Carpanese

Publikováno v: Nuclear Medicine and Biology 43(2016)12, 788-801
Nuclear medicine and biology 43 (2016): 788–801. doi:10.1016/j.nucmedbio.2016.08.014
info:cnr-pdr/source/autori:Carta D.; Salvarese N.; Morellato N.; Gao F.; Sihver W.; Pietzsch H.J.; Biondi B.; Ruzza P.; Refosco F.; Carpanese D.; Rosato A.; Bolzati C./titolo:Melanoma targeting with [Tc-99m(N)(PNP3)]-labeled alpha-melanocyte stimulating hormone peptide analogs: Effects of cyclization on the radiopharmaceutical properties/doi:10.1016%2Fj.nucmedbio.2016.08.014/rivista:Nuclear medicine and biology/anno:2016/pagina_da:788/pagina_a:801/intervallo_pagine:788–801/volume:43

The purpose of this study was to evaluate the effect of cyclization on the biological profile of a [ 99m Tc(N)(PNP3)]-labeled α-melanocyte stimulating hormone peptide analog. A lactam bridge-cyclized H-Cys-Ahx-βAla 3 -c[Lys 4 -Glu-His-D-Phe-Arg-Trp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3677dfefd831e434bdfe15df2be3413e
https://www.hzdr.de/publications/Publ-24162-1

Assessment of the best N(3-) donors in preparation of [M(N)(PNP)]-based (M=(99m)Tc-; (188)Re) target-specific radiopharmaceuticals: Comparison among succinic dihydrazide (SDH), N-methyl-S-methyl dithiocarbazate (HDTCZ) and PEGylated N-methyl-S-methyl dithiocarbazate (HO2C-PEG600-DTCZ)

Autor: Nicolò Morellato, Stefan Thieme, Davide Carta, Paolo Ruzza, Cristina Bolzati, Christian Jentschel, Hans-Jürgen Pietzsch, Fiorenzo Refosco, Nicola Salvarese, Ralf Bergmann

Publikováno v: Nuclear medicine and biology 41 (2014): 570–581. doi:10.1016/j.nucmedbio.2014.04.126
info:cnr-pdr/source/autori:Carta D.; Jentschel C.; Thieme S.; Salvarese N.; Morellato N.; Refosco F.; Ruzza P.; Bergmann R.; Pietzsch H.-J.; Bolzati C./titolo:Assessment of the best N3-donors in preparation of [M(N)(PNP)]-based (M=Tc-99m-; Re-188) target-specific radiopharmaceuticals: Comparison among succinic dihydrazide (SDH), N-methyl-S-methyl dithiocarbazate (HDTCZ) and PEGylated N-methyl-S-methyl dithiocarbazate (HO2C-PEG(600)-DTCZ)/doi:10.1016%2Fj.nucmedbio.2014.04.126/rivista:Nuclear medicine and biology/anno:2014/pagina_da:570/pagina_a:581/intervallo_pagine:570–581/volume:41

Succinic dihydrazide (SDH), N-methyl-S-methyl dithiocarbazate (HDTCZ) and PEGylated N-methyl-S-methyl dithiocarbazate (HO2C-PEG600-DTCZ) are nitrido nitrogen atom donors employed for the preparation of nitride [M(N)]-complexes (M=(99m)Tc and (188)Re)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaa558ebafa3e50321f0731c342d2bc3
https://pubmed.ncbi.nlm.nih.gov/24909864

Tc-III-based mixed complexes for the design and the development of new SPECT tracers

Autor: Fiorenzo Refosco, Antonio Rosato, Alessandro Dolmella, Nicolò Morellato, Nicola Salvarese, Debora Carpanese, Laura Meléndez-Alafort, Cristina Bolzati

Publikováno v: Nuclear medicine and biology 41 (2014): 625–625. doi:10.1016/j.nucmedbio.2014.05.030
info:cnr-pdr/source/autori:Salvarese, N.; Morellato, N.; Dolmella, A.; Melendez-Alafort, L.; Carpanese, D.; Rosato, A.; Refosco, F.; Bolzati, C./titolo:Tc-III-based mixed complexes for the design and the development of new SPECT tracers/doi:10.1016%2Fj.nucmedbio.2014.05.030/rivista:Nuclear medicine and biology/anno:2014/pagina_da:625/pagina_a:625/intervallo_pagine:625–625/volume:41

The trivalent state is the most stable oxidation state of technetium and rhenium, however, none of the radiopharmaceuticals currently in clinical use contains the metal in this oxidation state. We present here a general procedure for the preparation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f83003b3115f18812dacd70178436de1
http://www.cnr.it/prodotto/i/317981