Reciprocal regulation between alternative splicing and the DNA damage response

Autor: Adrian E. Cambindo Botto, Juan C. Muñoz, Luciana E. Giono, Nicolás Nieto-Moreno, Carmen Cuenca, Alberto R. Kornblihtt, Manuel J. Muñoz

Publikováno v: Genetics and Molecular Biology, Vol 43, Iss 1 suppl 1 (2020)

Abstract Splicing, the process that catalyzes intron removal and flanking exon ligation, can occur in different ways (alternative splicing) in immature RNAs transcribed from a single gene. In order to adapt to a particular context, cells modulate not

Externí odkaz: https://doaj.org/article/dd12ae2b7d9149b3bcdbfd8d03dc74e9

A DNA intercalating dye-based RT-qPCR alternative to diagnose SARS-CoV-2

Autor: Juan C. Muñoz, Gonzalo Cabrerizo, Marcos Palavecino, Manuel J. Muñoz, José N. Stigliano, Nicolás Nieto Moreno, Anabella Srebrow, Ignacio E Schor, Fabian Rudolf, Micaela A. Godoy Herz, Martín Avaro, Cybele C. García, Elsa Baumeister, Valeria Buggiano, Lucas Servi, Estefanía Benedetti, Federico Remes Lenicov, Alberto R. Kornblihtt, Laureano Bragado, Ezequiel Petrillo, Federico Fuchs Wightman, Andrea Pontoriero, José Clemente, Manuel de la Mata

Publikováno v: RNA Biology
article-version (VoR) Version of Record
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Early detection of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been proven crucial during the efforts to mitigate the effects of the COVID-19 pandemic. Several diagnostic methods have emerged in the past few months, each with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4ea169b5cfaedc2c38ee34ada322aa6
https://doi.org/10.1080/15476286.2021.1926648

Reciprocal regulation between alternative splicing and the DNA damage response

Autor: Alberto R. Kornblihtt, Carmen Cuenca, Juan Carlos Muñoz, Adrián E. Cambindo Botto, Luciana E. Giono, Manuel J. Muñoz, Nicolás Nieto-Moreno

Publikováno v: Genetics and Molecular Biology
Genetics and Molecular Biology, Vol 43, Iss 1 suppl 1 (2020)
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Genetics and Molecular Biology, Volume: 43, Issue: 1 Supplement 1, Article number: e20190111, Published: 27 MAR 2020
Genetics and Molecular Biology v.43 n.1 suppl.1 2020
Sociedade Brasileira de Genética (SBG)
instacron:SBG

Splicing, the process that catalyzes intron removal and flanking exon ligation, can occur in different ways (alternative splicing) in immature RNAs transcribed from a single gene. In order to adapt to a particular context, cells modulate not only the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75db3a8d5021131cb756636610c018b2
http://europepmc.org/articles/PMC7197977

Transcriptional elongation and alternative splicing

Autor: Ignacio E. Schor, Ezequiel Petrillo, Micaela A. Godoy Herz, Mariano Alló, Valeria Buggiano, Celina Lafaille, Manuel J. Muñoz, Nicolás Nieto Moreno, Gwendal Dujardin, Ana Fiszbein, Alberto R. Kornblihtt, Luciana Inés Gómez Acuña

Publikováno v: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1829:134-140

Alternative splicing has emerged as a key contributor to proteome diversity, highlighting the importance of understanding its regulation. In recent years it became apparent that splicing is predominantly cotranscriptional, allowing for crosstalk betw

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b67be3cf4f8b5f6c3c29bf97959dcc27
https://doi.org/10.1016/j.bbagrm.2012.08.005

Chromatin, DNA structure and alternative splicing

Autor: Alberto R. Kornblihtt, Adrián E. Cambindo Botto, Manuel J. Muñoz, Nicolás Nieto Moreno, Luciana E. Giono

Publikováno v: FEBS Letters. (22):3370-3378

Coupling of transcription and alternative splicing via regulation of the transcriptional elongation rate is a well-studied phenomenon. Template features that act as roadblocks for the progression of RNA polymerase II comprise histone modifications an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87a78f3b361cc37e39f07ec4ce3e2a4e