Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Nico Zinn"'
Autor:
Hannah V. Woodcock, Jessica D. Eley, Delphine Guillotin, Manuela Platé, Carmel B. Nanthakumar, Matteo Martufi, Simon Peace, Gerard Joberty, Daniel Poeckel, Robert B. Good, Adam R. Taylor, Nico Zinn, Matthew Redding, Ellen J. Forty, Robert E. Hynds, Charles Swanton, Morten Karsdal, Toby M. Maher, Andrew Fisher, Giovanna Bergamini, Richard P. Marshall, Andy D. Blanchard, Paul F. Mercer, Rachel C. Chambers
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
The PI3K/Akt/mTOR pathway has been previously implicated in fibrosis and a pan-PI3K/mTOR inhibitor is currently under clinical evaluation for the treatment of IPF. Here the authors show that the mTORC1/4E-BP1 axis is critical for TGF-β1-induced fibr
Externí odkaz:
https://doaj.org/article/c3c84960b35344d79ec192d4954f0d3a
Autor:
Toby Mathieson, Holger Franken, Jan Kosinski, Nils Kurzawa, Nico Zinn, Gavain Sweetman, Daniel Poeckel, Vikram S. Ratnu, Maike Schramm, Isabelle Becher, Michael Steidel, Kyung-Min Noh, Giovanna Bergamini, Martin Beck, Marcus Bantscheff, Mikhail M. Savitski
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
The proteome-wide characterization of proteostasis depends on robust approaches to determine protein half-lives. Here, the authors improve the accuracy and precision of mass spectrometry-based quantification, enabling reliable protein half-life deter
Externí odkaz:
https://doaj.org/article/da0726d0c6b44f4fa437f686bacfcd20
Autor:
Hannah V. Woodcock, Jessica D. Eley, Delphine Guillotin, Manuela Platé, Carmel B. Nanthakumar, Matteo Martufi, Simon Peace, Gerard Joberty, Daniel Poeckel, Robert B. Good, Adam R. Taylor, Nico Zinn, Matthew Redding, Ellen J. Forty, Robert E. Hynds, Charles Swanton, Morten Karsdal, Toby M. Maher, Andrew Fisher, Giovanna Bergamini, Richard P. Marshall, Andy D. Blanchard, Paul F. Mercer, Rachel C. Chambers
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/35a6295d2586420286eccc316b713105
Autor:
Han Dai, Robert P. Law, John P. Evans, Gillian F. Watt, Chun-wa Chung, Markus A. Queisser, John D. Harling, Antonia J. Lewis, Marcus Bantscheff, João Osvaldo Rodrigues Nunes, Adam Flinders, Paul Scott-Stevens, Andrew B. Benowitz, Peter Stacey, Christopher J. Tame, Karol Buda, Diana Klimaszewska, Marcel Muelbaier, Nico Zinn
Publikováno v:
Angewandte Chemie. 133:23515-23522
Focal adhesion kinase (FAK) is a key mediator of tumour progression and metastasis. To date, clinical trials of FAK inhibitors have reported disappointing efficacy for oncology indications. We report the design and characterisation of GSK215, a poten
Autor:
Jenni Cryan, Don T. Fisher, Michael Reilly, Ian Edward David Smith, Anna Vossenkämper, Gillian F. Watt, Ian Churcher, John D. Harling, Allison M. Beal, Thomas T. MacDonald, Alina Mares, Phoebe Dace, Bartholomew J. Votta, Marcus Bantscheff, Jane Denyer, Paul Scott-Stevens, Afjal Hussain Miah, Andrew B. Benowitz, Aditya R. Thawani, Carol A. Capriotti, Mark David Rackham, Nico Zinn, Pamela A. Haile
Publikováno v:
Communications Biology, Vol 3, Iss 1, Pp 1-13 (2020)
Communications Biology
Communications Biology
Proteolysis-Targeting Chimeras (PROTACs) are heterobifunctional small-molecules that can promote the rapid and selective proteasome-mediated degradation of intracellular proteins through the recruitment of E3 ligase complexes to non-native protein su
Autor:
Marcus Bantscheff, Daniel Poeckel, Ramanjulu Joshi M, Jessica Perrin, Christina Rau, Katrin Strohmer, Birgit Duempelfeld, Nico Zinn, G. Scott Pesiridis, Giovanna Bergamini, Marcel Muelbaier, Douglas W. Thomson, Anne J. Wagner, Viera Kasparcova, Alan P. Graves
Publikováno v:
ACS Med Chem Lett
[Image: see text] The serine/threonine protein kinase TBK1 (Tank-binding Kinase-1) is a noncanonical member of the IkB kinase (IKK) family. This kinase regulates signaling pathways in innate immunity, oncogenesis, energy homeostasis, autophagy, and n
Autor:
Carola Doce, Christian Fufezan, Marcus Bantscheff, Nico Zinn, Christine Boecker, Toby Mathieson, Thilo Werner, Gavain Sweetman
Publikováno v:
Journal of proteome research. 20(3)
Multiplexed quantitative proteomics enabled complex workflows to study the mechanisms by which small molecule drugs interact with the proteome such as thermal proteome profiling (TPP) or multiplexed proteome dynamics profiling (mPDP). TPP measures ch
Autor:
Muzamil Majid, Khan, Daniel, Poeckel, Aliaksandr, Halavatyi, Joanna, Zukowska-Kasprzyk, Frank, Stein, Johanna, Vappiani, Daniel C, Sevin, Christian, Tischer, Nico, Zinn, Jessica D, Eley, Natasja Stæhr, Gudmann, Thomas, Muley, Hauke, Winter, Andrew J, Fisher, Carmel B, Nanthakumar, Giovanna, Bergamini, Rainer, Pepperkok
Publikováno v:
The European respiratory journal. 58(1)
Fibrosis can affect any organ, resulting in the loss of tissue architecture and function with often life-threatening consequences. Pathologically, fibrosis is characterised by the expansion of connective tissue due to excessive deposition of extracel
Autor:
Aliaksandr Halavatyi, Andrew J. Fisher, Rainer Pepperkok, Johanna Vappiani, Thomas Muley, Giovanna Bergamini, Christian Tischer, Natasja Staehr Gudmann, Jessica D. Eley, Daniel C. Sévin, Hauke Winter, Frank Stein, Muzamil Majid Khan, Nico Zinn, Carmel B. Nanthakumar, Daniel Poeckel
Fibrosis can affect any organ resulting in the loss of tissue architecture and function with often life-threatening consequences. Pathologically, fibrosis is characterised by expansion of connective tissue due to excessive deposition of extracellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::437819a77789c432109344be2540b042
https://doi.org/10.1101/2019.12.13.875963
https://doi.org/10.1101/2019.12.13.875963
Autor:
Zhiliu Zhang, Demartino Michael P, Allen Oliff, Hilary SchenckEidam, Sanjay Kumar, Sharon Robinson, Mui Cheung, Gong Zhen, Yan Pan, Angela White, John Russell, Nico Zinn, Amanda Giddings, Sylvie Laquerre, Ehsan Mohammadi, Chengde Wu, Beverly Greenwood-Van Meerveld, Yu Haiyu, Donghui Qin, Gerard Joberty, Kaushik Raha, Guan Huiping Amy
Publikováno v:
ACS Medicinal Chemistry Letters. 9:623-628
[Image: see text] Abdominal pain and abnormal bowel habits represent major symptoms for irritable bowel syndrome (IBS) patients that are not adequately managed. Although the etiology of IBS is not completely understood, many of the functions of the g