Zobrazeno 1 - 10
of 176
pro vyhledávání: '"Nico Tjandra"'
Autor:
David A. Nyenhuis, Susan Watanabe, Rebecca Bernstein, Rolf E. Swenson, Natarajan Raju, Venkata R. Sabbasani, Chandrasekhar Mushti, Duck‐Yeon Lee, Carol Carter, Nico Tjandra
Publikováno v:
Advanced Science, Vol 11, Iss 18, Pp n/a-n/a (2024)
Abstract Here, an in vitro characterization of a family of prazole derivatives that covalently bind to the C73 site on Tsg101 and assay their ability to inhibit viral particle production is presented. Structurally, increased steric bulk on the 4‐py
Externí odkaz:
https://doaj.org/article/666403f4ef1f49f2bc0f62d5ed9b2a67
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Mitochondrial-derived peptides are encoded by mitochondrial DNA but have biological activity outside mitochondria. Eight of these are encoded by sequences within the mitochondrial 12S and 16S ribosomal genes: humanin, MOTS-c, and the six SHL
Externí odkaz:
https://doaj.org/article/1b561065f4574dbf9e15c13b009c1777
Autor:
Luiz F. M. Passalacqua, Mary R. Starich, Katie A. Link, Jiahui Wu, Jay R. Knutson, Nico Tjandra, Samie R. Jaffrey, Adrian R. Ferré-D’Amaré
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Beetroot is a homodimeric in vitro selected RNA that binds and activates DFAME, a conditional fluorophore derived from GFP. It is 70% sequence-identical to the previously characterized homodimeric aptamer Corn, which binds one molecule of it
Externí odkaz:
https://doaj.org/article/d5c0aa19bfa048f0b1fc7d7019110d05
Autor:
Madeleine Strickland, Lorna S. Ehrlich, Susan Watanabe, Mahfuz Khan, Marie-Paule Strub, Chi-Hao Luan, Michael D. Powell, Jonathan Leis, Nico Tjandra, Carol A. Carter
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Tsg101 is a component of the host cellular ESCRT machinery and is required for HIV-1 replication. Here, the authors show that disruption of ubiquitin binding of the Tsg101 UEV domain through commonly used drugs arrests virus assembly, which might fac
Externí odkaz:
https://doaj.org/article/2ecc918c7b1b4a77b36ae1b966756894
Publikováno v:
Viruses, Vol 13, Iss 6, p 1147 (2021)
Two decades ago, Tsg101, a component of the Endosomal Sorting Complexes Required for Transport (ESCRT) complex 1, was identified as a cellular factor recruited by the human immunodeficiency virus type 1 (HIV-1) to facilitate budding of viral particle
Externí odkaz:
https://doaj.org/article/5c181bb7926643de842a6fda8687ad90
Autor:
Hyeog Kang, Shinichi Oka, Duck-Yeon Lee, Junhong Park, Angel M. Aponte, Young-Sang Jung, Jacob Bitterman, Peiyong Zhai, Yi He, Hamed Kooshapur, Rodolfo Ghirlando, Nico Tjandra, Sean B. Lee, Myung K. Kim, Junichi Sadoshima, Jay H. Chung
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
The deacetylase Sirt1, known to regulate many cellular functions, can be activated by energy deprivation, however the mechanism is unclear. Here, the authors show that ATP inhibits Sirt1 by binding to the C-terminal domain, and energy deprivation der
Externí odkaz:
https://doaj.org/article/b6335290698541848579c1e330cc3914
Publikováno v:
Viruses, Vol 12, Iss 4, p 447 (2020)
The ESCRT-I factor Tsg101 is essential for sorting endocytic cargo and is exploited by viral pathogens to facilitate egress from cells. Both the nucleocapsid (NC) domain and p6 domain in HIV-1 Gag contribute to recruitment of the protein. However, th
Externí odkaz:
https://doaj.org/article/e07e2a9aa43c4f4382c93deb62d81496
Autor:
Christoph Göbl, Nico Tjandra
Publikováno v:
Entropy, Vol 14, Iss 3, Pp 581-598 (2012)
Recent advances in spectroscopic methods allow the identification of minute fluctuations in a protein structure. These dynamic properties have been identified as keys to some biological processes. The consequences of this structural flexibility can b
Externí odkaz:
https://doaj.org/article/911abbf2358440f18b9bffd70c32eab9
Publikováno v:
J Magn Reson
Paramagnetic NMR experiments, including the pseudocontact shift experiment, have seen increasing use due to recently developed probes and labeling strategies. The pseudocontact shift experiment can provide valuable intra- or inter-molecular distance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4a58a4038a81f56c6580a3d4f19ab2f
https://europepmc.org/articles/PMC9233152/
https://europepmc.org/articles/PMC9233152/