Transcriptomic analysis of intestinal organoids, derived from pigs divergent in feed efficiency, and their response to Escherichia coli

Autor: Ole Madsen, Roxann S.C. Rikkers, Jerry M. Wells, Rob Bergsma, Soumya K. Kar, Nico Taverne, Anja J. Taverne-Thiele, Esther D. Ellen, Henri Woelders

Publikováno v: BMC Genomics, Vol 25, Iss 1, Pp 1-17 (2024)

Abstract Background There is increasing interest in using intestinal organoids to study complex traits like feed efficiency (FE) and host-microbe interactions. The aim of this study was to investigate differences in the molecular phenotype of organoi

Externí odkaz: https://doaj.org/article/b973fd59652944b992bee4c6300870fa

Lipoproteins Contribute to the Anti-inflammatory Capacity of Lactobacillus plantarum WCFS1

Autor: I-Chiao Lee, Iris I. van Swam, Sjef Boeren, Jacques Vervoort, Marjolein Meijerink, Nico Taverne, Marjo Starrenburg, Peter A. Bron, Michiel Kleerebezem

Publikováno v: Frontiers in Microbiology, Vol 11 (2020)

Bacterial lipoproteins are well-recognized microorganism-associated molecular patterns, which interact with Toll-like receptor (TLR) 2, an important pattern recognition receptor of the host innate immune system. Lipoproteins are conjugated with two-

Externí odkaz: https://doaj.org/article/74352a27b4d04067bb3844a87f673565

Variabilities and similarities of adult stem cells derived intestinal organoids originating from different intestinal segments in pig

Autor: Soumya K Kar, Marinus F. W. te Pas, Roxann Rikkers, Ole Madsen, Nico Taverne, Esther D Ellen, Jerry M Wells, Dirkjan Schokker

1.ABSTRACTOrganoids arein vitromodel systems generated from tissues. Organoids express specific physiological functions associated with their original tissue location and they express tissue-segment-specific genes. The aim of this study was to cultur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a19d4f072bb43dbb2b6daa3f5814cceb
https://doi.org/10.1101/2022.12.14.520382

The agr Inhibitors Solonamide B and Analogues Alter Immune Responses to Staphylococccus aureus but Do Not Exhibit Adverse Effects on Immune Cell Functions.

Autor: Mara Baldry, Betül Kitir, Hanne Frøkiær, Simon B Christensen, Nico Taverne, Marjolein Meijerink, Henrik Franzyk, Christian A Olsen, Jerry M Wells, Hanne Ingmer

Publikováno v: PLoS ONE, Vol 11, Iss 1, p e0145618 (2016)

Staphylococcus aureus infections are becoming increasingly difficult to treat due to antibiotic resistance with the community-associated methicillin-resistant S. aureus (CA-MRSA) strains such as USA300 being of particular concern. The inhibition of b

Externí odkaz: https://doaj.org/article/69bb60bc987d46abba5415f1df43390d

Effects of undigested protein-rich ingredients on polarised small intestinal organoid monolayers

Autor: Alfons J. M. Jansman, Bart van der Hee, Dirkjan Schokker, Linda M. P. Loonen, Soumya K. Kar, J.J. Taverne-Thiele, Nico Taverne, Jerry M. Wells, Mari A. Smits

Publikováno v: Journal of Animal Science and Biotechnology 11 (2020) 1
Journal of Animal Science and Biotechnology, 11(1)
Journal of Animal Science and Biotechnology, Vol 11, Iss 1, Pp 1-7 (2020)
Journal of Animal Science and Biotechnology

Abstract Here, we describe the use of monolayers of intestinal epithelial cells derived from intestinal organoids and transcriptomics to investigate the direct effects of dietary protein sources on epithelial function. Mechanically dissociated 3D org

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::828220ff8a4d9743a931dcfd9f6a8b66
https://research.wur.nl/en/publications/effects-of-undigested-protein-rich-ingredients-on-polarised-small